FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085184297> ?p ?o ?g. }

• W2085184297 endingPage "2465" @default.
• W2085184297 startingPage "2461" @default.
• W2085184297 abstract "The human KAL gene is responsible for the X chromosome-linked Kallmann syndrome. A partial cDNA sequence from the chicken KAL homologue was determined and used to study expression of the KAL gene, by in situ hybridization, during chicken development, from day 6 of incubation. The KAL gene is mainly expressed in neurons of the central nervous system during the second half of embryonic life. High levels of transcript were detected in mitral neurons of the olfactory bulbs, in striatal neurons, in Purkinje cells of the cerebellum, in retinal neurons, and in isolated neurons of the brainstem and spinal cord. No expression was observed in glial cells. A low level of expression was observed in some mesenchymal derivatives. In the adult, expression is maintained or increased in several neuronal populations, especially in optic tectum and striatum. A possible role for the KAL protein in synaptogenesis at these stages is discussed. These results in the chicken embryo help to elucidate the mechanisms of anosmia and gonadotropin-releasing hormone deficiency, which define Kallmann syndrome. In addition, most of the occasional symptoms described in Kallmann syndrome patients, such as cerebellar ataxia, abnormal ocular movements, abnormal spatial visual attention, mirror movements, and renal aplasia, could be ascribed to malfunction of areas that, in the chicken, express the KAL gene." @default.
• W2085184297 created "2016-06-24" @default.
• W2085184297 creator A5042638213 @default.
• W2085184297 creator A5057007532 @default.
• W2085184297 creator A5057622020 @default.
• W2085184297 creator A5072048458 @default.
• W2085184297 creator A5081913458 @default.
• W2085184297 date "1993-03-15" @default.
• W2085184297 modified "2023-09-27" @default.
• W2085184297 title "Expression of the KAL gene in multiple neuronal sites during chicken development." @default.
• W2085184297 cites W1972242150 @default.
• W2085184297 cites W1975613307 @default.
• W2085184297 cites W1987098829 @default.
• W2085184297 cites W1992559178 @default.
• W2085184297 cites W1993957466 @default.
• W2085184297 cites W2011383191 @default.
• W2085184297 cites W2013806256 @default.
• W2085184297 cites W2015056774 @default.
• W2085184297 cites W2026777974 @default.
• W2085184297 cites W2029618197 @default.
• W2085184297 cites W2035725077 @default.
• W2085184297 cites W2041713925 @default.
• W2085184297 cites W2045854255 @default.
• W2085184297 cites W2062092256 @default.
• W2085184297 cites W2064723445 @default.
• W2085184297 cites W2068484329 @default.
• W2085184297 cites W2072070420 @default.
• W2085184297 cites W2076792446 @default.
• W2085184297 cites W2076924133 @default.
• W2085184297 cites W2080787328 @default.
• W2085184297 cites W2083605443 @default.
• W2085184297 cites W2084612709 @default.
• W2085184297 cites W2084751245 @default.
• W2085184297 cites W2086790274 @default.
• W2085184297 cites W2088905323 @default.
• W2085184297 cites W2134812217 @default.
• W2085184297 cites W2137888990 @default.
• W2085184297 cites W2138367242 @default.
• W2085184297 cites W2154889193 @default.
• W2085184297 cites W2167986100 @default.
• W2085184297 cites W2177077947 @default.
• W2085184297 cites W2397942523 @default.
• W2085184297 cites W2613217394 @default.
• W2085184297 doi "https://doi.org/10.1073/pnas.90.6.2461" @default.
• W2085184297 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/46107" @default.
• W2085184297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8460158" @default.
• W2085184297 hasPublicationYear "1993" @default.
• W2085184297 type Work @default.
• W2085184297 sameAs 2085184297 @default.
• W2085184297 citedByCount "63" @default.
• W2085184297 countsByYear W20851842972013 @default.
• W2085184297 countsByYear W20851842972016 @default.
• W2085184297 countsByYear W20851842972019 @default.
• W2085184297 countsByYear W20851842972020 @default.
• W2085184297 countsByYear W20851842972021 @default.
• W2085184297 crossrefType "journal-article" @default.
• W2085184297 hasAuthorship W2085184297A5042638213 @default.
• W2085184297 hasAuthorship W2085184297A5057007532 @default.
• W2085184297 hasAuthorship W2085184297A5057622020 @default.
• W2085184297 hasAuthorship W2085184297A5072048458 @default.
• W2085184297 hasAuthorship W2085184297A5081913458 @default.
• W2085184297 hasBestOaLocation W20851842972 @default.
• W2085184297 hasConcept C104317684 @default.
• W2085184297 hasConcept C126322002 @default.
• W2085184297 hasConcept C134018914 @default.
• W2085184297 hasConcept C150194340 @default.
• W2085184297 hasConcept C2777882087 @default.
• W2085184297 hasConcept C2779652256 @default.
• W2085184297 hasConcept C2780496858 @default.
• W2085184297 hasConcept C529278444 @default.
• W2085184297 hasConcept C54355233 @default.
• W2085184297 hasConcept C65232495 @default.
• W2085184297 hasConcept C71924100 @default.
• W2085184297 hasConcept C81439078 @default.
• W2085184297 hasConcept C86803240 @default.
• W2085184297 hasConcept C95444343 @default.
• W2085184297 hasConceptScore W2085184297C104317684 @default.
• W2085184297 hasConceptScore W2085184297C126322002 @default.
• W2085184297 hasConceptScore W2085184297C134018914 @default.
• W2085184297 hasConceptScore W2085184297C150194340 @default.
• W2085184297 hasConceptScore W2085184297C2777882087 @default.
• W2085184297 hasConceptScore W2085184297C2779652256 @default.
• W2085184297 hasConceptScore W2085184297C2780496858 @default.
• W2085184297 hasConceptScore W2085184297C529278444 @default.
• W2085184297 hasConceptScore W2085184297C54355233 @default.
• W2085184297 hasConceptScore W2085184297C65232495 @default.
• W2085184297 hasConceptScore W2085184297C71924100 @default.
• W2085184297 hasConceptScore W2085184297C81439078 @default.
• W2085184297 hasConceptScore W2085184297C86803240 @default.
• W2085184297 hasConceptScore W2085184297C95444343 @default.
• W2085184297 hasIssue "6" @default.
• W2085184297 hasLocation W20851842971 @default.
• W2085184297 hasLocation W20851842972 @default.
• W2085184297 hasLocation W20851842973 @default.
• W2085184297 hasLocation W20851842974 @default.
• W2085184297 hasOpenAccess W2085184297 @default.
• W2085184297 hasPrimaryLocation W20851842971 @default.
• W2085184297 hasRelatedWork W1978423642 @default.

• next