Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085186615> ?p ?o ?g. }
- W2085186615 endingPage "767" @default.
- W2085186615 startingPage "767" @default.
- W2085186615 abstract "Drugs for solid cancer the productivity crisis prompts a rethink Daniel Rösel,1 Jan Brábek,1 Pavel Veselý,2 Michael Fernandes3 1Department of Cell Biology, Charles University in Prague, Prague, Czech Republic; 2Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic; 3Medbase, Chapel Hill, NC, USA Abstract: Despite remarkable progress in cancer-drug discovery, the delivery of novel, safe, and sustainably effective products to the clinic has stalled. Using Src as a model, we examine key steps in drug development. The preclinical evidence on the relationship between Src and solid cancer is in sharp contrast with the modest anticancer effect noted in conventional clinical trials. Here, we consider Src inhibitors as an example of a promising drug class directed to invasion and metastasis and identify roadblocks in translation. We question the assumption that a drug-induced tumor shrinkage in preclinical and clinical studies predicts a successful outcome. Our analysis indicates that the key areas requiring attention are related, and include preclinical models (in vitro and mouse models), meaningful clinical trial end points, and an appreciation of the role of metastasis in morbidity and mortality. Current regulations do not reflect the natural history of the disease, and may be unrelated to the key complications: local invasion, metastasis, and the development of resistance. Alignment of preclinical and clinical studies and regulations based on mechanistic trial end points and platforms may help in overcoming these roadblocks. Viewed kaleidoscopically, most elements necessary and sufficient for a novel translational paradigm are in place. Keywords: cancer, paradigms, Src inhibitors, metastasis, translation, drug resistance" @default.
- W2085186615 created "2016-06-24" @default.
- W2085186615 creator A5014848543 @default.
- W2085186615 creator A5026235186 @default.
- W2085186615 creator A5046706093 @default.
- W2085186615 creator A5061304637 @default.
- W2085186615 date "2013-06-01" @default.
- W2085186615 modified "2023-09-30" @default.
- W2085186615 title "Drugs for solid cancer the productivity crisis prompts a rethink" @default.
- W2085186615 cites W103694265 @default.
- W2085186615 cites W1522460523 @default.
- W2085186615 cites W1524209044 @default.
- W2085186615 cites W1536452773 @default.
- W2085186615 cites W1608352853 @default.
- W2085186615 cites W1895993106 @default.
- W2085186615 cites W1964404268 @default.
- W2085186615 cites W1966476566 @default.
- W2085186615 cites W1973671404 @default.
- W2085186615 cites W1977636829 @default.
- W2085186615 cites W1984040705 @default.
- W2085186615 cites W1992331087 @default.
- W2085186615 cites W1992831404 @default.
- W2085186615 cites W1993702531 @default.
- W2085186615 cites W1995977950 @default.
- W2085186615 cites W1996360865 @default.
- W2085186615 cites W1996540171 @default.
- W2085186615 cites W1997774562 @default.
- W2085186615 cites W1997994656 @default.
- W2085186615 cites W1998048991 @default.
- W2085186615 cites W1998558839 @default.
- W2085186615 cites W2002603913 @default.
- W2085186615 cites W2003973314 @default.
- W2085186615 cites W2004771750 @default.
- W2085186615 cites W2007040134 @default.
- W2085186615 cites W2010251891 @default.
- W2085186615 cites W2012084975 @default.
- W2085186615 cites W2013329576 @default.
- W2085186615 cites W2018478612 @default.
- W2085186615 cites W2019607817 @default.
- W2085186615 cites W2019978257 @default.
- W2085186615 cites W2024161072 @default.
- W2085186615 cites W2024262880 @default.
- W2085186615 cites W2028508216 @default.
- W2085186615 cites W2029113895 @default.
- W2085186615 cites W2030578167 @default.
- W2085186615 cites W2032225894 @default.
- W2085186615 cites W2039010280 @default.
- W2085186615 cites W2043265129 @default.
- W2085186615 cites W2046068483 @default.
- W2085186615 cites W2049252550 @default.
- W2085186615 cites W2050973237 @default.
- W2085186615 cites W2051940224 @default.
- W2085186615 cites W2052370726 @default.
- W2085186615 cites W2053470367 @default.
- W2085186615 cites W2054609442 @default.
- W2085186615 cites W2054792338 @default.
- W2085186615 cites W2060948080 @default.
- W2085186615 cites W2062789265 @default.
- W2085186615 cites W2066039259 @default.
- W2085186615 cites W2066715177 @default.
- W2085186615 cites W2068326740 @default.
- W2085186615 cites W2068854404 @default.
- W2085186615 cites W2069438671 @default.
- W2085186615 cites W2069834599 @default.
- W2085186615 cites W2070800535 @default.
- W2085186615 cites W2071867803 @default.
- W2085186615 cites W2074469498 @default.
- W2085186615 cites W2076575640 @default.
- W2085186615 cites W2078155300 @default.
- W2085186615 cites W2079238642 @default.
- W2085186615 cites W2079281935 @default.
- W2085186615 cites W2082281812 @default.
- W2085186615 cites W2082354253 @default.
- W2085186615 cites W2082429669 @default.
- W2085186615 cites W2083258699 @default.
- W2085186615 cites W2083277200 @default.
- W2085186615 cites W2090327853 @default.
- W2085186615 cites W2091336659 @default.
- W2085186615 cites W2092109670 @default.
- W2085186615 cites W2094335163 @default.
- W2085186615 cites W2098253798 @default.
- W2085186615 cites W2100662195 @default.
- W2085186615 cites W2103824791 @default.
- W2085186615 cites W2104208190 @default.
- W2085186615 cites W2108426094 @default.
- W2085186615 cites W2108914190 @default.
- W2085186615 cites W2111285159 @default.
- W2085186615 cites W2114678970 @default.
- W2085186615 cites W2115989405 @default.
- W2085186615 cites W2117692326 @default.
- W2085186615 cites W2124145705 @default.
- W2085186615 cites W2125385057 @default.
- W2085186615 cites W2126748582 @default.
- W2085186615 cites W2128275141 @default.
- W2085186615 cites W2128701004 @default.
- W2085186615 cites W2129398950 @default.
- W2085186615 cites W2130409834 @default.
- W2085186615 cites W2132194392 @default.