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• W2085189306 abstract "Among obeses, those with visceral fat distribution have a greater cardiovascular risk profile than those with peripheral distribution. However, up to now, it is not clear the implication of fat distribution pattern upon cardiac and renal alterations and ambulatory blood pressure monitoring (ABPM) variables in these patients. To evaluate the influence of adiposity distribution (ADP) on ABPM, heart rate (HR), cardiac structure and urinary albumin excretion (UAE) in normotensive (OBNT) and hypertensive (OBHT) obese patients. 37 OBNT women, 19 with visceral ADP (V-OBNT) and 18 with peripheric ADP (P-OBNT), 21 to 60 years, BMI 30,4 to 50 kg/m2 and 49 OBHT women, 37 V-OBHT and 12 P-OBHT, 26 to 65 years, BMI 30,1 to 40,8 kg/m2, were selected and submited to ABPM, echocardiography and UAE (post 4 week washout period) .Age, BMI and office BP was similar between obese subgroups. V and P-OBNT presented similar ABPM levels. Nonetheless, both day and night HR were higher in V-OBNT: 90,1±8,3 vs 80,4±10,9, p< 0,05 and 76±8,7 vs 70,4±7,5, p <0,04. Septal thickness (ST), was also greater in V-OBNT: 9,4±1,3 vs 8,5±1,0mm, p<0,03 but UAE was not different:10,7(4,6/43,1) vs 3,2(1,8/29,7). Independent parameters (waist-W, waist/hip-W/H, age, BMI, day/night-SBP, day/night-DBP, glucose and insulin) put in a multiple regression, denoted an impact of W on ST (p< 0,0008), posterior wall tickness (PW) (p<0,002) and of BMI and W/H on HR (p< 0,04; p< 0,008 respectively). Insulin predicted ST (p<0,002) and PW(p<0,003) when W and W/H were not in the model. In OBHT, visceral pattern predicted a less intense SBP dipping (SBPdp) (-9,5± 5,0 vs–12,9± 5,3 % observed in P-OBHT p<0,05) and a trend to higher night BP levels, but not HR levels. There was also a trend to greater cardiorenal injury degree in V-OBHT: left ventricular mass/height2,754,9±14 vs 50,2±5,6 g/m2,7; E/A 0,95±0,34 vs 1,12±0,5; UAE 36,5(6,1/96,1)vs15(7,6/66,6) mcg/min. For the whole OBHT group SBPdipping correlated with LVM/h 2,7 (r2-0,33, p<0,02), E/A (r20,27, p< 0,05) and UAE (r2-0,33, p<0,03). In multiple regression, night SPB was the best predictor variable for cardiorenal changes in OBHT. Visceral obesity in NT predicts changes in septum thickness and in heart rate, while in HT, V-obesity is a predictor for the lack of an adequate SBP dipping, which may play role in cardiorenal injury." @default.
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• W2085189306 date "2003-05-01" @default.
• W2085189306 modified "2023-10-02" @default.
• W2085189306 title "Adiposity distribution pattern predicts changes in night blood pressure pattern and cardiorenal lesions" @default.
• W2085189306 doi "https://doi.org/10.1016/s0895-7061(03)00693-9" @default.
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