FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085192542> ?p ?o ?g. }

• W2085192542 endingPage "H546" @default.
• W2085192542 startingPage "H538" @default.
• W2085192542 abstract "Estrogens are known to display significant vasoprotective effects in premenopausal women. PDGF is an important mediator of vascular smooth muscle cell (VSMC) migration and proliferation, and thus atherogenesis. We analyzed the effects of 17beta-estradiol (E2) on beta-PDGF receptor (beta-PDGFR) expression/activation and PDGF-dependent VSMC proliferation, migration, and downstream signaling events. Pretreatment of VSMCs with E2 (0.3 microM-0.1 mM) for 24 h concentration-dependently inhibited PDGF-induced proliferation and migration up to 85.5 +/- 15.8% and 79.4 +/- 9.8%, respectively (both P < 0.05). These effects were prevented by coincubation with the ER antagonist ICI-182780. E2 did not alter beta-PDGFR expression, nor did it impair the ligand-induced tyrosine phosphorylation of the beta-PDGFR and consecutive binding of the receptor-associated signaling molecules Src homology region 2-containing phosphatase-2, PLC-gamma, phosphatidylinositol 3-kinase, and RasGAP. Thus estrogens inhibited PDGF-induced cellular responses at the postreceptor level. Although stimulation of VSMCs with PDGF-BB led to a transient increase of rac-1 activity, pretreatment with E2 for 24 h concentration-dependently inhibited PDGF-induced rac-1 activation. Furthermore, inhibition of rac-1 by Clostridium sordellii lethal toxin or overexpression of dominant-negative rac-1 (rac-N17) significantly inhibited PDGF-induced VSMC migration, indicating that rac-1 activity is essential for PDGF-dependent cellular responses. E2 did not further reduce PDGF-induced migration in rac-N17-overexpressing cells, suggesting that it diminishes VSMC migration by altering rac-1 activity. We conclude that E2 attenuates PDGF-dependent cellular functions of VSMCs downstream of the beta-PDGFR via inhibition of rac-1. These observations offer a molecular explanation for the vasoprotective effects of estrogens." @default.
• W2085192542 created "2016-06-24" @default.
• W2085192542 creator A5013611546 @default.
• W2085192542 creator A5021419269 @default.
• W2085192542 creator A5044956133 @default.
• W2085192542 creator A5048931724 @default.
• W2085192542 creator A5056607562 @default.
• W2085192542 creator A5065401253 @default.
• W2085192542 creator A5071615850 @default.
• W2085192542 date "2006-02-01" @default.
• W2085192542 modified "2023-10-13" @default.
• W2085192542 title "17β-Estradiol attenuates PDGF signaling in vascular smooth muscle cells at the postreceptor level" @default.
• W2085192542 cites W1945199177 @default.
• W2085192542 cites W1963881127 @default.
• W2085192542 cites W1975502948 @default.
• W2085192542 cites W1993966022 @default.
• W2085192542 cites W2005831605 @default.
• W2085192542 cites W2011374440 @default.
• W2085192542 cites W2011591511 @default.
• W2085192542 cites W2019498844 @default.
• W2085192542 cites W2024406253 @default.
• W2085192542 cites W2027081120 @default.
• W2085192542 cites W2027962993 @default.
• W2085192542 cites W2034070845 @default.
• W2085192542 cites W2059215885 @default.
• W2085192542 cites W2069695725 @default.
• W2085192542 cites W2072749112 @default.
• W2085192542 cites W2076237030 @default.
• W2085192542 cites W2077297274 @default.
• W2085192542 cites W2080457355 @default.
• W2085192542 cites W2083800064 @default.
• W2085192542 cites W2087224363 @default.
• W2085192542 cites W2094924746 @default.
• W2085192542 cites W2098654050 @default.
• W2085192542 cites W2100272641 @default.
• W2085192542 cites W2103488319 @default.
• W2085192542 cites W2113264115 @default.
• W2085192542 cites W2114868315 @default.
• W2085192542 cites W2115341476 @default.
• W2085192542 cites W2118095126 @default.
• W2085192542 cites W2122246441 @default.
• W2085192542 cites W2137570167 @default.
• W2085192542 cites W2139401912 @default.
• W2085192542 cites W2142563473 @default.
• W2085192542 cites W2143015087 @default.
• W2085192542 cites W2144026996 @default.
• W2085192542 cites W2147020292 @default.
• W2085192542 cites W2150228169 @default.
• W2085192542 cites W2183788149 @default.
• W2085192542 cites W2186358774 @default.
• W2085192542 cites W2316008127 @default.
• W2085192542 cites W2322666266 @default.
• W2085192542 cites W2323923429 @default.
• W2085192542 cites W2615633554 @default.
• W2085192542 cites W2972867833 @default.
• W2085192542 doi "https://doi.org/10.1152/ajpheart.00240.2005" @default.
• W2085192542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16227346" @default.
• W2085192542 hasPublicationYear "2006" @default.
• W2085192542 type Work @default.
• W2085192542 sameAs 2085192542 @default.
• W2085192542 citedByCount "26" @default.
• W2085192542 countsByYear W20851925422012 @default.
• W2085192542 countsByYear W20851925422013 @default.
• W2085192542 countsByYear W20851925422014 @default.
• W2085192542 countsByYear W20851925422015 @default.
• W2085192542 countsByYear W20851925422023 @default.
• W2085192542 crossrefType "journal-article" @default.
• W2085192542 hasAuthorship W2085192542A5013611546 @default.
• W2085192542 hasAuthorship W2085192542A5021419269 @default.
• W2085192542 hasAuthorship W2085192542A5044956133 @default.
• W2085192542 hasAuthorship W2085192542A5048931724 @default.
• W2085192542 hasAuthorship W2085192542A5056607562 @default.
• W2085192542 hasAuthorship W2085192542A5065401253 @default.
• W2085192542 hasAuthorship W2085192542A5071615850 @default.
• W2085192542 hasConcept C11960822 @default.
• W2085192542 hasConcept C126322002 @default.
• W2085192542 hasConcept C134018914 @default.
• W2085192542 hasConcept C170493617 @default.
• W2085192542 hasConcept C180361614 @default.
• W2085192542 hasConcept C2775960820 @default.
• W2085192542 hasConcept C2777553839 @default.
• W2085192542 hasConcept C2779395532 @default.
• W2085192542 hasConcept C2781294074 @default.
• W2085192542 hasConcept C2992686903 @default.
• W2085192542 hasConcept C71924100 @default.
• W2085192542 hasConcept C86803240 @default.
• W2085192542 hasConcept C95444343 @default.
• W2085192542 hasConceptScore W2085192542C11960822 @default.
• W2085192542 hasConceptScore W2085192542C126322002 @default.
• W2085192542 hasConceptScore W2085192542C134018914 @default.
• W2085192542 hasConceptScore W2085192542C170493617 @default.
• W2085192542 hasConceptScore W2085192542C180361614 @default.
• W2085192542 hasConceptScore W2085192542C2775960820 @default.
• W2085192542 hasConceptScore W2085192542C2777553839 @default.
• W2085192542 hasConceptScore W2085192542C2779395532 @default.
• W2085192542 hasConceptScore W2085192542C2781294074 @default.
• W2085192542 hasConceptScore W2085192542C2992686903 @default.
• W2085192542 hasConceptScore W2085192542C71924100 @default.

• next