FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085192697> ?p ?o ?g. }

• W2085192697 endingPage "e42935" @default.
• W2085192697 startingPage "e42935" @default.
• W2085192697 abstract "Taurine is a sulfur-containing amino acid present in high concentrations in mammalian tissues. It has been implicated in several processes involving brain development and neurotransmission. However, the role of taurine in hippocampal neurogenesis during brain development is still unknown. Here we show that taurine regulates neural progenitor cell (NPC) proliferation in the dentate gyrus of the developing brain as well as in cultured early postnatal (P5) hippocampal progenitor cells and hippocampal slices derived from P5 mice brains. Taurine increased cell proliferation without having a significant effect on neural differentiation both in cultured P5 NPCs as well as cultured hippocampal slices and in vivo. Expression level analysis of synaptic proteins revealed that taurine increases the expression of Synapsin 1 and PSD 95. We also found that taurine stimulates the phosphorylation of ERK1/2 indicating a possible role of the ERK pathway in mediating the changes that we observed, especially in proliferation. Taken together, our results demonstrate a role for taurine in neural stem/progenitor cell proliferation in developing brain and suggest the involvement of the ERK1/2 pathways in mediating these actions. Our study also shows that taurine influences the levels of proteins associated with synapse development. This is the first evidence showing the effect of taurine on early postnatal neuronal development using a combination of in vitro, ex-vivo and in vivo systems." @default.
• W2085192697 created "2016-06-24" @default.
• W2085192697 creator A5011054045 @default.
• W2085192697 creator A5013576067 @default.
• W2085192697 creator A5025010274 @default.
• W2085192697 creator A5032038569 @default.
• W2085192697 creator A5034978105 @default.
• W2085192697 creator A5042159708 @default.
• W2085192697 creator A5063452672 @default.
• W2085192697 date "2012-08-20" @default.
• W2085192697 modified "2023-10-16" @default.
• W2085192697 title "Taurine Induces Proliferation of Neural Stem Cells and Synapse Development in the Developing Mouse Brain" @default.
• W2085192697 cites W136569546 @default.
• W2085192697 cites W1487695731 @default.
• W2085192697 cites W1529003705 @default.
• W2085192697 cites W1621984349 @default.
• W2085192697 cites W1834737933 @default.
• W2085192697 cites W1967075253 @default.
• W2085192697 cites W1967359502 @default.
• W2085192697 cites W1967896094 @default.
• W2085192697 cites W1980977775 @default.
• W2085192697 cites W1983955843 @default.
• W2085192697 cites W1986512833 @default.
• W2085192697 cites W2005209749 @default.
• W2085192697 cites W2006439957 @default.
• W2085192697 cites W2017297990 @default.
• W2085192697 cites W2017591430 @default.
• W2085192697 cites W2021288484 @default.
• W2085192697 cites W2022062897 @default.
• W2085192697 cites W2030197080 @default.
• W2085192697 cites W2038426596 @default.
• W2085192697 cites W2041949931 @default.
• W2085192697 cites W2048704894 @default.
• W2085192697 cites W2050440997 @default.
• W2085192697 cites W2053326179 @default.
• W2085192697 cites W2057166033 @default.
• W2085192697 cites W2057333072 @default.
• W2085192697 cites W2062525669 @default.
• W2085192697 cites W2067924915 @default.
• W2085192697 cites W2075572210 @default.
• W2085192697 cites W2079574769 @default.
• W2085192697 cites W2082080632 @default.
• W2085192697 cites W2087592242 @default.
• W2085192697 cites W2106839393 @default.
• W2085192697 cites W2117242960 @default.
• W2085192697 cites W2125095601 @default.
• W2085192697 cites W2140615341 @default.
• W2085192697 cites W2142407747 @default.
• W2085192697 cites W2143372016 @default.
• W2085192697 cites W2150014868 @default.
• W2085192697 cites W2150149283 @default.
• W2085192697 cites W2158269692 @default.
• W2085192697 cites W2160071886 @default.
• W2085192697 cites W2162507709 @default.
• W2085192697 cites W2166321551 @default.
• W2085192697 cites W2177909750 @default.
• W2085192697 cites W2272301129 @default.
• W2085192697 cites W2399759271 @default.
• W2085192697 cites W2468614879 @default.
• W2085192697 doi "https://doi.org/10.1371/journal.pone.0042935" @default.
• W2085192697 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3423436" @default.
• W2085192697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22916184" @default.
• W2085192697 hasPublicationYear "2012" @default.
• W2085192697 type Work @default.
• W2085192697 sameAs 2085192697 @default.
• W2085192697 citedByCount "79" @default.
• W2085192697 countsByYear W20851926972013 @default.
• W2085192697 countsByYear W20851926972014 @default.
• W2085192697 countsByYear W20851926972015 @default.
• W2085192697 countsByYear W20851926972016 @default.
• W2085192697 countsByYear W20851926972017 @default.
• W2085192697 countsByYear W20851926972018 @default.
• W2085192697 countsByYear W20851926972019 @default.
• W2085192697 countsByYear W20851926972020 @default.
• W2085192697 countsByYear W20851926972021 @default.
• W2085192697 countsByYear W20851926972022 @default.
• W2085192697 countsByYear W20851926972023 @default.
• W2085192697 crossrefType "journal-article" @default.
• W2085192697 hasAuthorship W2085192697A5011054045 @default.
• W2085192697 hasAuthorship W2085192697A5013576067 @default.
• W2085192697 hasAuthorship W2085192697A5025010274 @default.
• W2085192697 hasAuthorship W2085192697A5032038569 @default.
• W2085192697 hasAuthorship W2085192697A5034978105 @default.
• W2085192697 hasAuthorship W2085192697A5042159708 @default.
• W2085192697 hasAuthorship W2085192697A5063452672 @default.
• W2085192697 hasBestOaLocation W20851926971 @default.
• W2085192697 hasConcept C130316041 @default.
• W2085192697 hasConcept C136834591 @default.
• W2085192697 hasConcept C148762608 @default.
• W2085192697 hasConcept C148785051 @default.
• W2085192697 hasConcept C169760540 @default.
• W2085192697 hasConcept C201750760 @default.
• W2085192697 hasConcept C26987225 @default.
• W2085192697 hasConcept C2776464000 @default.
• W2085192697 hasConcept C2779701627 @default.
• W2085192697 hasConcept C2781161787 @default.
• W2085192697 hasConcept C28328180 @default.
• W2085192697 hasConcept C41625074 @default.

• next