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• W2085193712 abstract "Mixed epithelial-stromal tumour of the kidney is a distinct category of renal neoplasm, defined by Michal and Syrucek. Increasingly recognised over the past few years, this typically benign bimorphic lesion is characterised morphologically by admixed solid and cystic regions that have variable cellularity and growth patterns. We report an unusual case of mixed epithelial-stromal tumour of the kidney, which recurred soon after definitive surgery in an aggressive manner. Because most cases have been reported as benign localised disease amenable to surgical resection, little information is available on treatment of these tumours with chemotherapy. In this patient, chemotherapy resulted in a symptomatic response. A 53-year-old woman presented in July, 2001, with abdominal discomfort from a very large mass in her right upper quadrant. Abdominal ultrasound showed a large cystic mass abutting the liver and the right kidney. CT showed a well-circumscribed 18 18 26 cm mass with solid and cystic components. The mass arose from the right kidney and displaced the right kidney and inferior vena cava medially. The patient underwent right nephrectomy and tumour excision. At surgery, the tumour had the appearance of a large rubber sponge infiltrating from the kidney into the perirenal adipose tissue; other organs had not been invaded. The tumour ruptured during surgery and was removed in fragments. Postoperative adjuvant treatment was not given. Pathological examination showed an unusual bimorphic tumour consisting of multicystic and solid components (figure 1A). The kidney was partly replaced by circumscribed tumour, which was extensively disrupted and fragmented. The relations with the perinephric fat and renal fascia were lost. Neither the venous nor the urinary collecting systems seemed to be involved by the tumour. Excision margins were clear. The cysts or tubules were simple and were lined by benign cuboidal epithelium (figure 1B). The solid component of the tumour consisted mainly of a spindle-cell proliferation of" @default.
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• W2085193712 date "2004-12-01" @default.
• W2085193712 modified "2023-09-25" @default.
• W2085193712 title "Aggressive mixed epithelial-stromal tumour of the kidney treated with chemotherapy and radiotherapy" @default.
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• W2085193712 doi "https://doi.org/10.1016/s1470-2045(04)01651-1" @default.
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