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- W2085194041 abstract "We analyzed the allelic polymorphisms in seven Y-specific microsatellite loci and a Y-spe cific alphoid system with 27 variants (hl-XXVII). A total of 53 Y chromosomes carrying the DYS 199T al?ele and belonging to Amerindian (51 ) and Na-Dene (2) linguistic groups were studied. The information gathered allowed us to identify the ancestral founder haplotype (OA) and to recognize 7 derived haplogroups diverging from OA by 1-7 mutational steps. The OA haplotype was the most frequent and had the following al?ele constitution: DYS199T; hll; DYS19/13; DYS389A/10; DYS389b/27; DYS390/24; DYS391/10; DYS392/ 14; DYS393/13 (microsatellite al?eles are indicated as number of repeats). All native Americans had the DYS199T al?ele and the hll form. Since there are no indications of recurrency for the DYS1990T transition, we concluded that all DYS199T haplotypes were derived from a single individual in which the C>T mutation occurred for the first time; we call this individual a New World Adam. We analyzed the Y-specific microsatellite mutation rate in 1743 father-son transmissions and we pooled our data with equivalent information in literature to obtain an average rate of 0.0018. We could estimate that the OA haplotype has an aver age age of 33,750 years (minimum 20,250 and maximum 88,050 years). DYS199T al?ele is found in 85-90% of Amerindian chromosomes indicat" @default.
- W2085194041 created "2016-06-24" @default.
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- W2085194041 date "2000-07-01" @default.
- W2085194041 modified "2023-10-14" @default.
- W2085194041 title "MOLECULAR APPROACH TO THE PEOPLING OF THE AMERICAS BY SEQUENCING mtDNA FROM EXTINCT FUEGUIANS AND PATAGONS" @default.
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- W2085194041 doi "https://doi.org/10.4067/s0717-73562000000200020" @default.
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