FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085194817> ?p ?o ?g. }

• W2085194817 endingPage "156" @default.
• W2085194817 startingPage "151" @default.
• W2085194817 abstract "p68 RNA helicase has been implicated in a variety of processes, including rearrangement of RNA secondary structures, RNA splicing, gene transcription and tumor development, yet its mechanisms of action are not well understood. In this study, we show that p68 is predominantly localized to the cell nucleus, where it partially colocalizes with the transcriptional coactivator p300. Accordingly, p68 and p300, or the paralogous CREB-binding protein (CBP), coimmunoprecipitate. Similarly, p68 and RNA polymerase II (Pol II) are able to interact in vivo. GST pull-down assays confirmed these interactions in vitro, demonstrating that p68 can interact with several domains of CBP, while CBP/p300 bind to amino acids 176–388 of p68 and RNA Pol II binds to the N-terminal 80 amino acids of p68. Furthermore, p68 stimulates transcription mediated by the C-terminal transactivation domain of CBP. p68 is also able to stimulate TPA oncogene responsive unit (TORU) promoter activity, and p300 acts in synergy with p68. On the other hand, suppression of CBP/p300 function by the adenoviral protein E1A abolishes TORU promoter activation by p68. Altogether, our results suggest the existence of a multiprotein complex in which p68 RNA helicase, CBP/p300 and RNA Pol II jointly promote gene expression." @default.
• W2085194817 created "2016-06-24" @default.
• W2085194817 creator A5046942450 @default.
• W2085194817 creator A5075879167 @default.
• W2085194817 date "2003-01-09" @default.
• W2085194817 modified "2023-10-18" @default.
• W2085194817 title "Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300" @default.
• W2085194817 cites W123322873 @default.
• W2085194817 cites W146972387 @default.
• W2085194817 cites W1712759494 @default.
• W2085194817 cites W1884928119 @default.
• W2085194817 cites W1931257488 @default.
• W2085194817 cites W1975232450 @default.
• W2085194817 cites W2010168383 @default.
• W2085194817 cites W2022703044 @default.
• W2085194817 cites W2036590917 @default.
• W2085194817 cites W2046074640 @default.
• W2085194817 cites W2046314213 @default.
• W2085194817 cites W2046436308 @default.
• W2085194817 cites W2046764234 @default.
• W2085194817 cites W2049252087 @default.
• W2085194817 cites W2051848082 @default.
• W2085194817 cites W2062883197 @default.
• W2085194817 cites W2064970842 @default.
• W2085194817 cites W2076491431 @default.
• W2085194817 cites W2088802322 @default.
• W2085194817 cites W2096934025 @default.
• W2085194817 cites W2119245063 @default.
• W2085194817 cites W2148032010 @default.
• W2085194817 cites W2154895224 @default.
• W2085194817 cites W2168943199 @default.
• W2085194817 cites W2314144775 @default.
• W2085194817 cites W2327261337 @default.
• W2085194817 doi "https://doi.org/10.1038/sj.onc.1206067" @default.
• W2085194817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12527917" @default.
• W2085194817 hasPublicationYear "2003" @default.
• W2085194817 type Work @default.
• W2085194817 sameAs 2085194817 @default.
• W2085194817 citedByCount "100" @default.
• W2085194817 countsByYear W20851948172012 @default.
• W2085194817 countsByYear W20851948172013 @default.
• W2085194817 countsByYear W20851948172014 @default.
• W2085194817 countsByYear W20851948172015 @default.
• W2085194817 countsByYear W20851948172016 @default.
• W2085194817 countsByYear W20851948172017 @default.
• W2085194817 countsByYear W20851948172018 @default.
• W2085194817 countsByYear W20851948172019 @default.
• W2085194817 countsByYear W20851948172020 @default.
• W2085194817 countsByYear W20851948172021 @default.
• W2085194817 countsByYear W20851948172022 @default.
• W2085194817 countsByYear W20851948172023 @default.
• W2085194817 crossrefType "journal-article" @default.
• W2085194817 hasAuthorship W2085194817A5046942450 @default.
• W2085194817 hasAuthorship W2085194817A5075879167 @default.
• W2085194817 hasBestOaLocation W20851948171 @default.
• W2085194817 hasConcept C101762097 @default.
• W2085194817 hasConcept C104317684 @default.
• W2085194817 hasConcept C1292079 @default.
• W2085194817 hasConcept C138885662 @default.
• W2085194817 hasConcept C150194340 @default.
• W2085194817 hasConcept C153911025 @default.
• W2085194817 hasConcept C161223559 @default.
• W2085194817 hasConcept C179926584 @default.
• W2085194817 hasConcept C41895202 @default.
• W2085194817 hasConcept C54355233 @default.
• W2085194817 hasConcept C54458228 @default.
• W2085194817 hasConcept C64350747 @default.
• W2085194817 hasConcept C67705224 @default.
• W2085194817 hasConcept C68592252 @default.
• W2085194817 hasConcept C77445288 @default.
• W2085194817 hasConcept C86339819 @default.
• W2085194817 hasConcept C86803240 @default.
• W2085194817 hasConcept C95444343 @default.
• W2085194817 hasConceptScore W2085194817C101762097 @default.
• W2085194817 hasConceptScore W2085194817C104317684 @default.
• W2085194817 hasConceptScore W2085194817C1292079 @default.
• W2085194817 hasConceptScore W2085194817C138885662 @default.
• W2085194817 hasConceptScore W2085194817C150194340 @default.
• W2085194817 hasConceptScore W2085194817C153911025 @default.
• W2085194817 hasConceptScore W2085194817C161223559 @default.
• W2085194817 hasConceptScore W2085194817C179926584 @default.
• W2085194817 hasConceptScore W2085194817C41895202 @default.
• W2085194817 hasConceptScore W2085194817C54355233 @default.
• W2085194817 hasConceptScore W2085194817C54458228 @default.
• W2085194817 hasConceptScore W2085194817C64350747 @default.
• W2085194817 hasConceptScore W2085194817C67705224 @default.
• W2085194817 hasConceptScore W2085194817C68592252 @default.
• W2085194817 hasConceptScore W2085194817C77445288 @default.
• W2085194817 hasConceptScore W2085194817C86339819 @default.
• W2085194817 hasConceptScore W2085194817C86803240 @default.
• W2085194817 hasConceptScore W2085194817C95444343 @default.
• W2085194817 hasIssue "1" @default.
• W2085194817 hasLocation W20851948171 @default.
• W2085194817 hasLocation W20851948172 @default.
• W2085194817 hasOpenAccess W2085194817 @default.
• W2085194817 hasPrimaryLocation W20851948171 @default.
• W2085194817 hasRelatedWork W2003328296 @default.
• W2085194817 hasRelatedWork W2023305892 @default.

• next