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- W2085194919 abstract "(1) In two cases of alkaptonuria chromatography of the patients' urine showed two spots differing in RF, but giving positive reactions characteristic for homogentisic acid. One of these substances, which is soluble in ether, is identical with homogentisic acid. (2) The water-soluble but ether-insoluble derivative of homogentisic acid represents a compound of the acid with glycine. During hydrolysis with hydrochloric acid it splits to free glycine and a derivative of homogentisic acid which is probably its lactone. (3) In one of the cases of alkaptonuria investigated by us the glycine compound constituted approximately 25% of the total amount of homogentisic acid excreted with the urine. This amount was increased after administration by mouth of pure homogentisic acid to the patient." @default.
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- W2085194919 date "1962-03-01" @default.
- W2085194919 modified "2023-09-25" @default.
- W2085194919 title "The bound form of homogentisic acid in alkaptonuric urine" @default.
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- W2085194919 doi "https://doi.org/10.1016/0009-8981(62)90016-5" @default.
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