FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085202542> ?p ?o ?g. }

• W2085202542 endingPage "10" @default.
• W2085202542 startingPage "2" @default.
• W2085202542 abstract "The focus of the management of Mycobacterium avium disease in human immunodeficiency virus (HIV)-infected persons has shifted from treatment to prevention with the identification of effective prophylactic agents such as azithromycin, clarithromycin, and rifabutin. It is believed that M. avium disease is preceded by an ill-defined period of M. avium colonization of the respiratory tract or, probably more commonly, the gastrointestinal tract. It is most likely that disease occurs when the level and/or complexity (number of strains with perhaps different levels of virulence) of M. avium colonization reaches a critical threshold in combination with the development of a critical immunodeficiency, which places a patient at risk for infection. Indeed, the relationship between HIV infection and M. avium infection is unclear, and the combined effect of the two infections may influence the course and severity of each. The mechanism(s) of action of prophylactic agents for M. avium are also ill-defined, and the occurrence of breakthrough disease with strains of M. avium that are susceptible to the inhibitory effects of macrolides or rifabutin suggests that the subinhibitory effects of these agents may be important for a prophylactic effect. Nevertheless, a significant percentage of breakthrough does occur with strains that are resistant to clarithromycin (58%) or azithromycin (11%), and the rapid and accurate detection of these strains is important for the successful management of M. avium disease. Resistance to azithromycin has been defined as a minimum inhibitory concentration (MIC) ≥256 μg/mL, while resistance to clarithromycin has been defined as a MIC ≥32 μg/mL. The in vitro susceptibility of M. avium to azithromycin and clarithromycin can be reliably determined using a radiometric (Bactec) broth macrodilution assay. In addition, a molecular assay has been described that is both highly sensitive and specific for detecting mutations that are the primary cause of macrolide resistance." @default.
• W2085202542 created "2016-06-24" @default.
• W2085202542 creator A5089845055 @default.
• W2085202542 date "1997-05-01" @default.
• W2085202542 modified "2023-10-16" @default.
• W2085202542 title "Microbiology and Minimum Inhibitory Concentration Testing for Mycobacterium avium Complex Prophylaxis" @default.
• W2085202542 cites W1520431631 @default.
• W2085202542 cites W1561499859 @default.
• W2085202542 cites W1588602846 @default.
• W2085202542 cites W1602908224 @default.
• W2085202542 cites W1604615224 @default.
• W2085202542 cites W1639953769 @default.
• W2085202542 cites W1741355380 @default.
• W2085202542 cites W1801839563 @default.
• W2085202542 cites W1917102629 @default.
• W2085202542 cites W1966257452 @default.
• W2085202542 cites W1968999800 @default.
• W2085202542 cites W1973114959 @default.
• W2085202542 cites W1980329033 @default.
• W2085202542 cites W1980700706 @default.
• W2085202542 cites W1991224641 @default.
• W2085202542 cites W2007285245 @default.
• W2085202542 cites W2009700955 @default.
• W2085202542 cites W2026824371 @default.
• W2085202542 cites W2030004297 @default.
• W2085202542 cites W2036049710 @default.
• W2085202542 cites W2040152410 @default.
• W2085202542 cites W2054707817 @default.
• W2085202542 cites W2069247240 @default.
• W2085202542 cites W2072767714 @default.
• W2085202542 cites W2078291344 @default.
• W2085202542 cites W2095412964 @default.
• W2085202542 cites W2101646216 @default.
• W2085202542 cites W2103998251 @default.
• W2085202542 cites W2106203358 @default.
• W2085202542 cites W2108028061 @default.
• W2085202542 cites W2111540873 @default.
• W2085202542 cites W2119242789 @default.
• W2085202542 cites W2120625220 @default.
• W2085202542 cites W2121948813 @default.
• W2085202542 cites W2122406101 @default.
• W2085202542 cites W2130500685 @default.
• W2085202542 cites W2134564948 @default.
• W2085202542 cites W2136667466 @default.
• W2085202542 cites W2139007482 @default.
• W2085202542 cites W2139180069 @default.
• W2085202542 cites W2140903514 @default.
• W2085202542 cites W2143479232 @default.
• W2085202542 cites W2144581072 @default.
• W2085202542 cites W2147251439 @default.
• W2085202542 cites W2148443863 @default.
• W2085202542 cites W2148933923 @default.
• W2085202542 cites W2152073160 @default.
• W2085202542 cites W2155186392 @default.
• W2085202542 cites W2156128675 @default.
• W2085202542 cites W2157515185 @default.
• W2085202542 cites W2160004892 @default.
• W2085202542 cites W2163211275 @default.
• W2085202542 cites W2166026344 @default.
• W2085202542 cites W2167019193 @default.
• W2085202542 cites W2199432652 @default.
• W2085202542 cites W2315930068 @default.
• W2085202542 cites W2336284588 @default.
• W2085202542 cites W2338479447 @default.
• W2085202542 doi "https://doi.org/10.1016/s0002-9343(97)00037-5" @default.
• W2085202542 hasPublicationYear "1997" @default.
• W2085202542 type Work @default.
• W2085202542 sameAs 2085202542 @default.
• W2085202542 citedByCount "15" @default.
• W2085202542 countsByYear W20852025422016 @default.
• W2085202542 countsByYear W20852025422020 @default.
• W2085202542 crossrefType "journal-article" @default.
• W2085202542 hasAuthorship W2085202542A5089845055 @default.
• W2085202542 hasConcept C114851261 @default.
• W2085202542 hasConcept C126322002 @default.
• W2085202542 hasConcept C142724271 @default.
• W2085202542 hasConcept C159047783 @default.
• W2085202542 hasConcept C176947019 @default.
• W2085202542 hasConcept C203014093 @default.
• W2085202542 hasConcept C2775961462 @default.
• W2085202542 hasConcept C2776962512 @default.
• W2085202542 hasConcept C2778907293 @default.
• W2085202542 hasConcept C2779134260 @default.
• W2085202542 hasConcept C2780374374 @default.
• W2085202542 hasConcept C2780867798 @default.
• W2085202542 hasConcept C2781069245 @default.
• W2085202542 hasConcept C2781455004 @default.
• W2085202542 hasConcept C3019249092 @default.
• W2085202542 hasConcept C501593827 @default.
• W2085202542 hasConcept C71924100 @default.
• W2085202542 hasConcept C86803240 @default.
• W2085202542 hasConcept C89423630 @default.
• W2085202542 hasConceptScore W2085202542C114851261 @default.
• W2085202542 hasConceptScore W2085202542C126322002 @default.
• W2085202542 hasConceptScore W2085202542C142724271 @default.
• W2085202542 hasConceptScore W2085202542C159047783 @default.
• W2085202542 hasConceptScore W2085202542C176947019 @default.
• W2085202542 hasConceptScore W2085202542C203014093 @default.

• next