FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085203246> ?p ?o ?g. }

• W2085203246 endingPage "991" @default.
• W2085203246 startingPage "986" @default.
• W2085203246 abstract "Altered expression of the retinoblastoma (RB) tumour-suppressor gene product (pRB) has been detected in sporadic bone and soft-tissue sarcomas. Earlier studies, analysing small cohorts of sarcoma patients, have suggested that these alterations are more commonly associated with high-grade tumours, metastatic lesions and poorer survival. This study was designed to re-examine the prevalence and clinical significance of altered pRB expression in a large and selected group of soft-tissue sarcomas from 174 adult patients. Representative tissue sections from these sarcomas were analysed by immunohistochemistry using a well-characterised anti-pRB monoclonal antibody. Tumours were considered to have a positive pRB phenotype only when pure nuclear staining was demonstrated, and cases were segregated into one of three groups. Group 1 (n = 36) were patients whose tumours have minimal or undetectable pRB nuclear staining (< 20% of tumour cells) and were considered pRB negative. Patients with tumours staining in a heterogeneous pattern (20-79% of tumour cells) were classified as group 2 (n = 99). The staining of group 3 (n = 39) was strongly positive with a homogeneous pRB nuclear immunoreactivity (80-100% of tumour cells). pRB alterations were frequently observed in both low- and high-grade lesions. Altered pRB expression did not correlate with known predictors of survival and was not itself an independent predictor of outcome in the long-term follow-up. These findings support earlier observations that alterations of pRB expression are common events in soft-tissue sarcomas; nevertheless, long-term follow-up results indicate that altered patterns of pRB expression do not influence clinical outcome of patients affected with soft-tissue sarcomas. It is postulated that RB alterations are primary events in human sarcomas and may be involved in tumorigenesis or early phases of tumour progression in these neoplasias." @default.
• W2085203246 created "2016-06-24" @default.
• W2085203246 creator A5000374070 @default.
• W2085203246 creator A5001429431 @default.
• W2085203246 creator A5007551884 @default.
• W2085203246 creator A5024966253 @default.
• W2085203246 creator A5046496959 @default.
• W2085203246 creator A5053926080 @default.
• W2085203246 creator A5067579135 @default.
• W2085203246 creator A5072628061 @default.
• W2085203246 creator A5080940311 @default.
• W2085203246 creator A5091524151 @default.
• W2085203246 date "1995-10-01" @default.
• W2085203246 modified "2023-10-18" @default.
• W2085203246 title "Altered patterns of retinoblastoma gene product expression in adult soft-tissue sarcomas" @default.
• W2085203246 cites W1542993965 @default.
• W2085203246 cites W1556555576 @default.
• W2085203246 cites W1725873114 @default.
• W2085203246 cites W177982968 @default.
• W2085203246 cites W1918248799 @default.
• W2085203246 cites W1975142290 @default.
• W2085203246 cites W1975172819 @default.
• W2085203246 cites W2012034467 @default.
• W2085203246 cites W2028006541 @default.
• W2085203246 cites W2034440981 @default.
• W2085203246 cites W2035975217 @default.
• W2085203246 cites W2038252730 @default.
• W2085203246 cites W2040834490 @default.
• W2085203246 cites W2055162988 @default.
• W2085203246 cites W2063367127 @default.
• W2085203246 cites W2066980099 @default.
• W2085203246 cites W2077858999 @default.
• W2085203246 cites W2079601821 @default.
• W2085203246 cites W2086322317 @default.
• W2085203246 cites W2087726910 @default.
• W2085203246 cites W2092543937 @default.
• W2085203246 cites W2093517913 @default.
• W2085203246 cites W2099742439 @default.
• W2085203246 cites W2114738441 @default.
• W2085203246 cites W2140558717 @default.
• W2085203246 cites W2159652547 @default.
• W2085203246 cites W2218450753 @default.
• W2085203246 cites W2340379762 @default.
• W2085203246 cites W2404099824 @default.
• W2085203246 cites W2410874782 @default.
• W2085203246 cites W2463922415 @default.
• W2085203246 cites W51410346 @default.
• W2085203246 cites W2406166485 @default.
• W2085203246 doi "https://doi.org/10.1038/bjc.1995.447" @default.
• W2085203246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2034041" @default.
• W2085203246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7547254" @default.
• W2085203246 hasPublicationYear "1995" @default.
• W2085203246 type Work @default.
• W2085203246 sameAs 2085203246 @default.
• W2085203246 citedByCount "65" @default.
• W2085203246 countsByYear W20852032462012 @default.
• W2085203246 countsByYear W20852032462014 @default.
• W2085203246 countsByYear W20852032462015 @default.
• W2085203246 countsByYear W20852032462018 @default.
• W2085203246 countsByYear W20852032462019 @default.
• W2085203246 countsByYear W20852032462020 @default.
• W2085203246 countsByYear W20852032462021 @default.
• W2085203246 countsByYear W20852032462022 @default.
• W2085203246 crossrefType "journal-article" @default.
• W2085203246 hasAuthorship W2085203246A5000374070 @default.
• W2085203246 hasAuthorship W2085203246A5001429431 @default.
• W2085203246 hasAuthorship W2085203246A5007551884 @default.
• W2085203246 hasAuthorship W2085203246A5024966253 @default.
• W2085203246 hasAuthorship W2085203246A5046496959 @default.
• W2085203246 hasAuthorship W2085203246A5053926080 @default.
• W2085203246 hasAuthorship W2085203246A5067579135 @default.
• W2085203246 hasAuthorship W2085203246A5072628061 @default.
• W2085203246 hasAuthorship W2085203246A5080940311 @default.
• W2085203246 hasAuthorship W2085203246A5091524151 @default.
• W2085203246 hasBestOaLocation W20852032461 @default.
• W2085203246 hasConcept C104317684 @default.
• W2085203246 hasConcept C121608353 @default.
• W2085203246 hasConcept C136948725 @default.
• W2085203246 hasConcept C142724271 @default.
• W2085203246 hasConcept C150194340 @default.
• W2085203246 hasConcept C195286587 @default.
• W2085203246 hasConcept C204232928 @default.
• W2085203246 hasConcept C2776062698 @default.
• W2085203246 hasConcept C2776577112 @default.
• W2085203246 hasConcept C2778256501 @default.
• W2085203246 hasConcept C2778264664 @default.
• W2085203246 hasConcept C29537977 @default.
• W2085203246 hasConcept C502942594 @default.
• W2085203246 hasConcept C54355233 @default.
• W2085203246 hasConcept C55493867 @default.
• W2085203246 hasConcept C555283112 @default.
• W2085203246 hasConcept C71924100 @default.
• W2085203246 hasConcept C74864618 @default.
• W2085203246 hasConcept C86803240 @default.
• W2085203246 hasConceptScore W2085203246C104317684 @default.
• W2085203246 hasConceptScore W2085203246C121608353 @default.
• W2085203246 hasConceptScore W2085203246C136948725 @default.
• W2085203246 hasConceptScore W2085203246C142724271 @default.

• next