Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085203955> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2085203955 endingPage "96" @default.
- W2085203955 startingPage "89" @default.
- W2085203955 abstract "An experimentally induced and reversible model of a neuronal storage disease, swainsonine-induced feline alpha-mannosidosis, has been used to study the modifiability of ectopic, axon hillock-associated neurites and their new synaptic contacts. Earlier studies have fully documented that a variety of neuronal storage disorders are characterized by such changes in neuronal geometry and connectivity. Swainsonine administration was ended after 6 months of continuous treatment which had resulted in characteristic signs of alpha-mannosidosis. Studies of this animal 6 months after reversal showed that even though neuronal vacuolation and other CNS changes essentially normalized, ectopic neurites and their synaptic connections were still present and appeared similar to those of another animal which had been treated with swainsonine for the entire 12-month period. These results suggest that once initiated during the disease process, ectopic axon hillock-associated dendrites become an integral part of the soma-dendritic domain of affected neurons and may not be reversible. These findings may have relevance for current attempts to devise therapies involving enzyme replacement for individuals with inherited neuronal storage disease." @default.
- W2085203955 created "2016-06-24" @default.
- W2085203955 creator A5014110814 @default.
- W2085203955 creator A5045148387 @default.
- W2085203955 creator A5064005799 @default.
- W2085203955 date "1987-04-01" @default.
- W2085203955 modified "2023-09-27" @default.
- W2085203955 title "Ectopic axon hillock-associated neurite growth is maintained in metabolically reversed swainsonine-induced neuronal storage disease" @default.
- W2085203955 cites W1993912261 @default.
- W2085203955 cites W2011077097 @default.
- W2085203955 cites W2011681204 @default.
- W2085203955 cites W2012959468 @default.
- W2085203955 cites W2014534699 @default.
- W2085203955 cites W2014990079 @default.
- W2085203955 cites W2033583612 @default.
- W2085203955 cites W2055170574 @default.
- W2085203955 cites W2058610411 @default.
- W2085203955 cites W2059527835 @default.
- W2085203955 cites W2061541835 @default.
- W2085203955 cites W2067356449 @default.
- W2085203955 cites W2069273177 @default.
- W2085203955 cites W2078167412 @default.
- W2085203955 cites W2144061574 @default.
- W2085203955 cites W2328590583 @default.
- W2085203955 doi "https://doi.org/10.1016/s0006-8993(87)80025-2" @default.
- W2085203955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3107757" @default.
- W2085203955 hasPublicationYear "1987" @default.
- W2085203955 type Work @default.
- W2085203955 sameAs 2085203955 @default.
- W2085203955 citedByCount "23" @default.
- W2085203955 countsByYear W20852039552012 @default.
- W2085203955 countsByYear W20852039552013 @default.
- W2085203955 countsByYear W20852039552014 @default.
- W2085203955 countsByYear W20852039552017 @default.
- W2085203955 countsByYear W20852039552020 @default.
- W2085203955 countsByYear W20852039552021 @default.
- W2085203955 crossrefType "journal-article" @default.
- W2085203955 hasAuthorship W2085203955A5014110814 @default.
- W2085203955 hasAuthorship W2085203955A5045148387 @default.
- W2085203955 hasAuthorship W2085203955A5064005799 @default.
- W2085203955 hasConcept C113246987 @default.
- W2085203955 hasConcept C142724271 @default.
- W2085203955 hasConcept C16744765 @default.
- W2085203955 hasConcept C169760540 @default.
- W2085203955 hasConcept C202751555 @default.
- W2085203955 hasConcept C2775928797 @default.
- W2085203955 hasConcept C2779134260 @default.
- W2085203955 hasConcept C2779530196 @default.
- W2085203955 hasConcept C2780130745 @default.
- W2085203955 hasConcept C55493867 @default.
- W2085203955 hasConcept C71924100 @default.
- W2085203955 hasConcept C86803240 @default.
- W2085203955 hasConceptScore W2085203955C113246987 @default.
- W2085203955 hasConceptScore W2085203955C142724271 @default.
- W2085203955 hasConceptScore W2085203955C16744765 @default.
- W2085203955 hasConceptScore W2085203955C169760540 @default.
- W2085203955 hasConceptScore W2085203955C202751555 @default.
- W2085203955 hasConceptScore W2085203955C2775928797 @default.
- W2085203955 hasConceptScore W2085203955C2779134260 @default.
- W2085203955 hasConceptScore W2085203955C2779530196 @default.
- W2085203955 hasConceptScore W2085203955C2780130745 @default.
- W2085203955 hasConceptScore W2085203955C55493867 @default.
- W2085203955 hasConceptScore W2085203955C71924100 @default.
- W2085203955 hasConceptScore W2085203955C86803240 @default.
- W2085203955 hasIssue "1" @default.
- W2085203955 hasLocation W20852039551 @default.
- W2085203955 hasLocation W20852039552 @default.
- W2085203955 hasOpenAccess W2085203955 @default.
- W2085203955 hasPrimaryLocation W20852039551 @default.
- W2085203955 hasRelatedWork W1976945845 @default.
- W2085203955 hasRelatedWork W2000272148 @default.
- W2085203955 hasRelatedWork W2039623701 @default.
- W2085203955 hasRelatedWork W2065916848 @default.
- W2085203955 hasRelatedWork W2085203955 @default.
- W2085203955 hasRelatedWork W2100976322 @default.
- W2085203955 hasRelatedWork W2161924903 @default.
- W2085203955 hasRelatedWork W2513782468 @default.
- W2085203955 hasRelatedWork W2970249272 @default.
- W2085203955 hasRelatedWork W2781569756 @default.
- W2085203955 hasVolume "410" @default.
- W2085203955 isParatext "false" @default.
- W2085203955 isRetracted "false" @default.
- W2085203955 magId "2085203955" @default.
- W2085203955 workType "article" @default.