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- W2085204443 abstract "Harmol (7-hydroxy-1-methyl-9H-pyrido-(3,4b)indol) is excreted in bile and urine of rats after an i.v. dose of 20 μmoles/kg in the form of harmol-sulfate and harmol-glucuronide. Ligation of the kidneys caused a compensatory higher biliary excretion of the conjugates. In the isolated perfused rat liver harmol was presented to the liver at two doses: 3 and 15 μmoles. At the lower dose equal amounts of harmol-sulfate and harmol-glucuronide were present in bile. Due to the five-fold increase in harmol dose, a three-fold increase in the biliary excretion of harmol-sulfate was observed but an eleven-fold increase in that of harmol-glucuronide, during the two hours of the perfusion. This effect can be explained by in vitro kinetic data on phenolsulfotransferase (EC 2.8.2.1) and UDP glucuronyltransferase (EC 2.4.1.17) and by the situation of competition of these enzymes for the same substrate harmol in vivo. The results suggest a model of harmol conjugation and elimination in which: (1) with increasing substrate supply glucuronidation is increased relative to sulfation; (2) harmol-glucuronide, once formed, is rapidly excreted in bile; and (3) harmol-sulfate is excreted in bile at a low rate, such that this step is rate limiting." @default.
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- W2085204443 date "1975-01-01" @default.
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- W2085204443 title "UDP glucuronyltransferase and phenolsulfotransferase from rat liver in vivo and in vitro" @default.
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- W2085204443 doi "https://doi.org/10.1016/0006-2952(75)90321-4" @default.
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