FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085205746> ?p ?o ?g. }

• W2085205746 endingPage "3526" @default.
• W2085205746 startingPage "3519" @default.
• W2085205746 abstract "We have reported [Bucci, E., Fronticelli, C., & Grycznski, Z. (1991) Biochemistry 30, 3195-3199] that in human and bovine hemoglobins the release of heat at the subsequent steps of oxygenation is not constant. This is especially evident in the binding of the third O2 molecule, which is an endothermic event. This phenomenon was attributed to peculiar conformations of the intermediates of oxygenation, not included in the fundamental R/T transition of the system. To test this hypothesis, we have explored the effect of conformational constraints on the thermodynamics of the intermediates of oxygenation. The assumption was that intramolecular constraints would stabilize the intermediates into conformations similar to the R and T forms reducing the variability of their enthalpies. We have analyzed the temperature dependence of the oxygen binding isotherms of human hemoglobin cross-linked either between the beta 82 or between the alpha 99 lysines by bis(3,5-dibromosalicyl)fumarate. The measurements were perfomred at pH 9.0 in 0.1 M borate buffer in order to avoid thermal effects due to oxygen-linked binding of anions and protons. The data were analyzed singularly by local procedures and simultaneously using global procedures. The two cross-links had opposite effects. The cross-link between the beta-subunits decreased while that between the alpha-subunits increased the endothermic behavior of the third step of oxygenation. Also, the cross-link between the beta-subunits increased the fractional amount of the triligated species at intermediate stages of oxygenation, while that between the alpha-subunits decreased this quantity to hardly detectable values.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2085205746 created "2016-06-24" @default.
• W2085205746 creator A5010242514 @default.
• W2085205746 creator A5010327441 @default.
• W2085205746 creator A5020510945 @default.
• W2085205746 creator A5024479756 @default.
• W2085205746 creator A5049422690 @default.
• W2085205746 date "1993-04-13" @default.
• W2085205746 modified "2023-09-25" @default.
• W2085205746 title "Effect of intramolecular cross-links on the enthalpy and quaternary structure of the intermediates of oxygenation of human hemoglobin" @default.
• W2085205746 cites W1502439966 @default.
• W2085205746 cites W1509530718 @default.
• W2085205746 cites W1554966787 @default.
• W2085205746 cites W166881372 @default.
• W2085205746 cites W1948960263 @default.
• W2085205746 cites W1966390261 @default.
• W2085205746 cites W1967526285 @default.
• W2085205746 cites W1987169929 @default.
• W2085205746 cites W1987472989 @default.
• W2085205746 cites W1987600134 @default.
• W2085205746 cites W1995968944 @default.
• W2085205746 cites W1997875905 @default.
• W2085205746 cites W1999724806 @default.
• W2085205746 cites W2010712250 @default.
• W2085205746 cites W2016743071 @default.
• W2085205746 cites W2018979674 @default.
• W2085205746 cites W2021868453 @default.
• W2085205746 cites W2029642116 @default.
• W2085205746 cites W2033719181 @default.
• W2085205746 cites W2033895258 @default.
• W2085205746 cites W2035248283 @default.
• W2085205746 cites W2040037741 @default.
• W2085205746 cites W2043052035 @default.
• W2085205746 cites W2049620948 @default.
• W2085205746 cites W2057960443 @default.
• W2085205746 cites W2067340304 @default.
• W2085205746 cites W2073275980 @default.
• W2085205746 cites W2077978370 @default.
• W2085205746 cites W2079403579 @default.
• W2085205746 cites W2080240343 @default.
• W2085205746 cites W2093487114 @default.
• W2085205746 cites W2094950362 @default.
• W2085205746 cites W2155337737 @default.
• W2085205746 cites W2171489775 @default.
• W2085205746 cites W230984257 @default.
• W2085205746 cites W1991300076 @default.
• W2085205746 doi "https://doi.org/10.1021/bi00065a001" @default.
• W2085205746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8466896" @default.
• W2085205746 hasPublicationYear "1993" @default.
• W2085205746 type Work @default.
• W2085205746 sameAs 2085205746 @default.
• W2085205746 citedByCount "14" @default.
• W2085205746 countsByYear W20852057462012 @default.
• W2085205746 crossrefType "journal-article" @default.
• W2085205746 hasAuthorship W2085205746A5010242514 @default.
• W2085205746 hasAuthorship W2085205746A5010327441 @default.
• W2085205746 hasAuthorship W2085205746A5020510945 @default.
• W2085205746 hasAuthorship W2085205746A5024479756 @default.
• W2085205746 hasAuthorship W2085205746A5049422690 @default.
• W2085205746 hasConcept C121332964 @default.
• W2085205746 hasConcept C147789679 @default.
• W2085205746 hasConcept C150394285 @default.
• W2085205746 hasConcept C178790620 @default.
• W2085205746 hasConcept C185592680 @default.
• W2085205746 hasConcept C18903297 @default.
• W2085205746 hasConcept C20976626 @default.
• W2085205746 hasConcept C2778917026 @default.
• W2085205746 hasConcept C3288061 @default.
• W2085205746 hasConcept C32909587 @default.
• W2085205746 hasConcept C540031477 @default.
• W2085205746 hasConcept C55493867 @default.
• W2085205746 hasConcept C70289976 @default.
• W2085205746 hasConcept C71240020 @default.
• W2085205746 hasConcept C75079739 @default.
• W2085205746 hasConcept C8010536 @default.
• W2085205746 hasConcept C86803240 @default.
• W2085205746 hasConcept C97355855 @default.
• W2085205746 hasConceptScore W2085205746C121332964 @default.
• W2085205746 hasConceptScore W2085205746C147789679 @default.
• W2085205746 hasConceptScore W2085205746C150394285 @default.
• W2085205746 hasConceptScore W2085205746C178790620 @default.
• W2085205746 hasConceptScore W2085205746C185592680 @default.
• W2085205746 hasConceptScore W2085205746C18903297 @default.
• W2085205746 hasConceptScore W2085205746C20976626 @default.
• W2085205746 hasConceptScore W2085205746C2778917026 @default.
• W2085205746 hasConceptScore W2085205746C3288061 @default.
• W2085205746 hasConceptScore W2085205746C32909587 @default.
• W2085205746 hasConceptScore W2085205746C540031477 @default.
• W2085205746 hasConceptScore W2085205746C55493867 @default.
• W2085205746 hasConceptScore W2085205746C70289976 @default.
• W2085205746 hasConceptScore W2085205746C71240020 @default.
• W2085205746 hasConceptScore W2085205746C75079739 @default.
• W2085205746 hasConceptScore W2085205746C8010536 @default.
• W2085205746 hasConceptScore W2085205746C86803240 @default.
• W2085205746 hasConceptScore W2085205746C97355855 @default.
• W2085205746 hasIssue "14" @default.
• W2085205746 hasLocation W20852057461 @default.
• W2085205746 hasLocation W20852057462 @default.

• next