FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085205907> ?p ?o ?g. }

• W2085205907 endingPage "29" @default.
• W2085205907 startingPage "20" @default.
• W2085205907 abstract "Mouse models of cystic fibrosis (CF) display increased sulfotransferase 1E1 (SULT1E1) activity in hepatocytes of cystic fibrosis transmembrane receptor (CFTR)-deficient animals. SULT1E1 is responsible for the sulfation and inactivation of beta-estradiol (E2) at physiological concentrations. IGF-1 message levels in CFTR(-/-) mouse livers were positively correlated with body weight and negatively correlated with SULT1E1 activity. Growth hormone (GH) is important in the regulation of hepatic IGF-1 expression indicating that E2 levels are involved with GH signaling in hepatocytes. To investigate the effects of E2 and SULT1E1 activity on GH signal transduction in human hepatocytes, SULT1E1 was stably expressed in HepG2 cells. Effects of increased E2 sulfation on the GH signaling pathway and E2-regulated gene expression were examined. Pretreatment of HepG2 cells with 10nM E2 prior to GH stimulation increased STAT5b phosphorylation and IGF-1 expression. In SULT1E1-transfected HepG2 cells, GH-stimulated STAT5b phosphorylation was significantly decreased. E2 treatment had no effect on STAT5b phosphorylation in the absence of GH stimulation. E2 also had no effect on Jak-2 phosphorylation. E2 has an apparent rapid action on increasing GH-stimulated STAT5b phosphorylation that was not attenuated by the estrogen receptor antagonist, ICI 182,780. Physiological levels of E2 in HepG2 cells increase GH stimulation of IGF-1 production apparently through increased phosphorylated STAT5b levels and transcriptional activation of the IGF-1 gene. The enhanced SULT1E1 activity may have a role in inhibiting GH-stimulated STAT5b phosphorylation and IGF-1 synthesis via the sulfation and inactivation of E2." @default.
• W2085205907 created "2016-06-24" @default.
• W2085205907 creator A5027475930 @default.
• W2085205907 creator A5048094144 @default.
• W2085205907 creator A5060860340 @default.
• W2085205907 creator A5071712264 @default.
• W2085205907 creator A5072622157 @default.
• W2085205907 date "2009-01-01" @default.
• W2085205907 modified "2023-09-23" @default.
• W2085205907 title "Increased SULT1E1 activity in HepG2 hepatocytes decreases growth hormone stimulation of STAT5b phosphorylation" @default.
• W2085205907 cites W100460973 @default.
• W2085205907 cites W1565310327 @default.
• W2085205907 cites W1573745866 @default.
• W2085205907 cites W1849763436 @default.
• W2085205907 cites W1961863882 @default.
• W2085205907 cites W1968379731 @default.
• W2085205907 cites W1970830865 @default.
• W2085205907 cites W1971013426 @default.
• W2085205907 cites W1974368689 @default.
• W2085205907 cites W1974656027 @default.
• W2085205907 cites W1977383354 @default.
• W2085205907 cites W1984390200 @default.
• W2085205907 cites W1984485388 @default.
• W2085205907 cites W1987325291 @default.
• W2085205907 cites W1990862668 @default.
• W2085205907 cites W1996685603 @default.
• W2085205907 cites W1997595275 @default.
• W2085205907 cites W2004109787 @default.
• W2085205907 cites W2010309531 @default.
• W2085205907 cites W2023205840 @default.
• W2085205907 cites W2024905084 @default.
• W2085205907 cites W2025206161 @default.
• W2085205907 cites W2025810223 @default.
• W2085205907 cites W2046352136 @default.
• W2085205907 cites W2050734581 @default.
• W2085205907 cites W2059794064 @default.
• W2085205907 cites W2068733105 @default.
• W2085205907 cites W2076373773 @default.
• W2085205907 cites W2078224907 @default.
• W2085205907 cites W2087794372 @default.
• W2085205907 cites W2095395822 @default.
• W2085205907 cites W2117010948 @default.
• W2085205907 cites W2119282322 @default.
• W2085205907 cites W2120056767 @default.
• W2085205907 cites W2124966147 @default.
• W2085205907 cites W2130145312 @default.
• W2085205907 cites W2138022079 @default.
• W2085205907 cites W2138317884 @default.
• W2085205907 cites W2144665452 @default.
• W2085205907 cites W2146131278 @default.
• W2085205907 cites W2147047572 @default.
• W2085205907 cites W2154214370 @default.
• W2085205907 cites W2182325994 @default.
• W2085205907 cites W2225397561 @default.
• W2085205907 cites W2323532050 @default.
• W2085205907 cites W2398763352 @default.
• W2085205907 cites W2402879648 @default.
• W2085205907 cites W2412863312 @default.
• W2085205907 cites W31230477 @default.
• W2085205907 cites W4251865367 @default.
• W2085205907 doi "https://doi.org/10.1016/j.steroids.2008.09.002" @default.
• W2085205907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2633718" @default.
• W2085205907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18831980" @default.
• W2085205907 hasPublicationYear "2009" @default.
• W2085205907 type Work @default.
• W2085205907 sameAs 2085205907 @default.
• W2085205907 citedByCount "16" @default.
• W2085205907 countsByYear W20852059072012 @default.
• W2085205907 countsByYear W20852059072013 @default.
• W2085205907 countsByYear W20852059072014 @default.
• W2085205907 countsByYear W20852059072017 @default.
• W2085205907 countsByYear W20852059072018 @default.
• W2085205907 countsByYear W20852059072019 @default.
• W2085205907 countsByYear W20852059072020 @default.
• W2085205907 countsByYear W20852059072021 @default.
• W2085205907 countsByYear W20852059072022 @default.
• W2085205907 crossrefType "journal-article" @default.
• W2085205907 hasAuthorship W2085205907A5027475930 @default.
• W2085205907 hasAuthorship W2085205907A5048094144 @default.
• W2085205907 hasAuthorship W2085205907A5060860340 @default.
• W2085205907 hasAuthorship W2085205907A5071712264 @default.
• W2085205907 hasAuthorship W2085205907A5072622157 @default.
• W2085205907 hasBestOaLocation W20852059072 @default.
• W2085205907 hasConcept C11960822 @default.
• W2085205907 hasConcept C126322002 @default.
• W2085205907 hasConcept C134018914 @default.
• W2085205907 hasConcept C155138218 @default.
• W2085205907 hasConcept C24998067 @default.
• W2085205907 hasConcept C55493867 @default.
• W2085205907 hasConcept C62478195 @default.
• W2085205907 hasConcept C71924100 @default.
• W2085205907 hasConcept C86803240 @default.
• W2085205907 hasConcept C95444343 @default.
• W2085205907 hasConceptScore W2085205907C11960822 @default.
• W2085205907 hasConceptScore W2085205907C126322002 @default.
• W2085205907 hasConceptScore W2085205907C134018914 @default.
• W2085205907 hasConceptScore W2085205907C155138218 @default.
• W2085205907 hasConceptScore W2085205907C24998067 @default.

• next