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- W2085206863 abstract "Abstract The effects of certain vasopressins (VPs), prostaglandins (PGs) and catecholamines on active transport across the ciliary epithelium have been investigated in vitro and an attempt has been made to relate the findings to the actions of these substances in vivo. Natural VP and lysine8-VP at physiological concentrations increased the transepithelial short-circuit current in vitro and, when infused intravenously into rabbits whose endogenous VP level had been suppressed by prior administration of ethanol, caused a significant increase of ocular tension. It is suggested that in intact animals, the naturally occurring variations of endogenous VP level in the blood may play a role in the physiological regulation of intraocular pressure. PGE1, PGE2 and PGF2α stimulate short-circuit current in vitro, the E-type PGs being considerably more effective than PGF2α. The response to E1 and E2 was antagonized by low molecular weight polyphoretin phosphate although the high molecular weight fraction was inactive. The PG concentrations required to exert this in vitro effect are well above those reported as causing ocular hypertension in vivo and it is suggested that the in vivo action may be due to increased permeability of the blood aqueous barrier rather than to stimulation of epithelial transport. Noradrenaline and isoprenaline at high concentrations also increase epithelial transport in vitro but it is thought that local vasoconstriction and effects on outflow facility predominatly determine the intraocular pressure responses at concentrations used in experiments on intact animals. The object of the present contribution is to describe the effects of some pharmacological substances on active transport across the ciliary epithelium and, particularly in the case of the vasopressins, to relate this action to the physiological control of intraocular pressure (IOP) and to the known in vitro actions of certain drugs." @default.
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- W2085206863 date "1973-08-01" @default.
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- W2085206863 title "Substances affecting active transport across the ciliary epithelium and their possible role in determining intraocular pressure" @default.
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- W2085206863 doi "https://doi.org/10.1016/0014-4835(73)90091-2" @default.
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