FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085207827> ?p ?o ?g. }

• W2085207827 endingPage "e2079" @default.
• W2085207827 startingPage "e2079" @default.
• W2085207827 abstract "DNA hypermethylation is a common epigenetic abnormality in cancer and may serve as a useful marker to clone cancer-related genes as well as a marker of clinical disease activity. To identify CpG islands methylated in prostate cancer, we used methylated CpG island amplification (MCA) coupled with representational difference analysis (RDA) on prostate cancer cell lines. We isolated 34 clones that corresponded to promoter CpG islands, including 5 reported targets of hypermethylation in cancer. We confirmed the data for 17 CpG islands by COBRA and/or pyrosequencing. All 17 genes were methylated in at least 2 cell lines of a 21-cancer cell line panel containing prostate cancer, colon cancer, leukemia, and breast cancer. Based on methylation in primary tumors compared to normal adjacent tissues, NKX2-5, CLSTN1, SPOCK2, SLC16A12, DPYS and NSE1 are candidate biomarkers for prostate cancer (methylation range 50%-85%). The combination of NSE1 or SPOCK2 hypermethylation showed a sensitivity of 80% and specificity of 95% in differentiating cancer from normal. Similarly NKX2-5, SPOCK2, SLC16A12, DPYS and GALR2 are candidate biomarkers for colon cancer (methylation range 60%-95%) and GALR2 hypermethylation showed a sensitivity of 85% and specificity of 95%. Finally, SLC16A12, GALR2, TOX, SPOCK2, EGFR5 and DPYS are candidate biomarkers for breast cancer (methylation range 33%-79%) with the combination of EGFR5 or TOX hypermethylation showing a sensitivity of 92% and specificity of 92%. Expression analysis for eight genes that had the most hypermethylation confirmed the methylation associated silencing and reactivation with 5-aza-2'-deoxycytidine treatment. Our data identify new targets of transcriptional silencing in cancer, and provide new biomarkers that could be useful in screening for prostate cancer and other cancers." @default.
• W2085207827 created "2016-06-24" @default.
• W2085207827 creator A5020254333 @default.
• W2085207827 creator A5022817844 @default.
• W2085207827 creator A5024370074 @default.
• W2085207827 creator A5027336256 @default.
• W2085207827 creator A5066263660 @default.
• W2085207827 creator A5075947272 @default.
• W2085207827 creator A5079853830 @default.
• W2085207827 date "2008-04-30" @default.
• W2085207827 modified "2023-10-18" @default.
• W2085207827 title "Identification of Novel Tumor Markers in Prostate, Colon and Breast Cancer by Unbiased Methylation Profiling" @default.
• W2085207827 cites W1484293540 @default.
• W2085207827 cites W1541216017 @default.
• W2085207827 cites W1552528612 @default.
• W2085207827 cites W1755052449 @default.
• W2085207827 cites W1968263601 @default.
• W2085207827 cites W1994078309 @default.
• W2085207827 cites W1996072637 @default.
• W2085207827 cites W2003363961 @default.
• W2085207827 cites W2010397777 @default.
• W2085207827 cites W2011491637 @default.
• W2085207827 cites W2015416439 @default.
• W2085207827 cites W2021349467 @default.
• W2085207827 cites W2024881804 @default.
• W2085207827 cites W2029506276 @default.
• W2085207827 cites W2040257851 @default.
• W2085207827 cites W2063110349 @default.
• W2085207827 cites W2068599501 @default.
• W2085207827 cites W2070006462 @default.
• W2085207827 cites W2073476335 @default.
• W2085207827 cites W2095718447 @default.
• W2085207827 cites W2100703820 @default.
• W2085207827 cites W2115314035 @default.
• W2085207827 cites W2147049379 @default.
• W2085207827 cites W2154891376 @default.
• W2085207827 cites W2167903105 @default.
• W2085207827 cites W2171788646 @default.
• W2085207827 cites W2317570906 @default.
• W2085207827 doi "https://doi.org/10.1371/journal.pone.0002079" @default.
• W2085207827 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2637099" @default.
• W2085207827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18446232" @default.
• W2085207827 hasPublicationYear "2008" @default.
• W2085207827 type Work @default.
• W2085207827 sameAs 2085207827 @default.
• W2085207827 citedByCount "114" @default.
• W2085207827 countsByYear W20852078272012 @default.
• W2085207827 countsByYear W20852078272013 @default.
• W2085207827 countsByYear W20852078272014 @default.
• W2085207827 countsByYear W20852078272015 @default.
• W2085207827 countsByYear W20852078272016 @default.
• W2085207827 countsByYear W20852078272017 @default.
• W2085207827 countsByYear W20852078272018 @default.
• W2085207827 countsByYear W20852078272019 @default.
• W2085207827 countsByYear W20852078272020 @default.
• W2085207827 countsByYear W20852078272021 @default.
• W2085207827 countsByYear W20852078272022 @default.
• W2085207827 countsByYear W20852078272023 @default.
• W2085207827 crossrefType "journal-article" @default.
• W2085207827 hasAuthorship W2085207827A5020254333 @default.
• W2085207827 hasAuthorship W2085207827A5022817844 @default.
• W2085207827 hasAuthorship W2085207827A5024370074 @default.
• W2085207827 hasAuthorship W2085207827A5027336256 @default.
• W2085207827 hasAuthorship W2085207827A5066263660 @default.
• W2085207827 hasAuthorship W2085207827A5075947272 @default.
• W2085207827 hasAuthorship W2085207827A5079853830 @default.
• W2085207827 hasBestOaLocation W20852078271 @default.
• W2085207827 hasConcept C104317684 @default.
• W2085207827 hasConcept C121608353 @default.
• W2085207827 hasConcept C140173407 @default.
• W2085207827 hasConcept C143998085 @default.
• W2085207827 hasConcept C150194340 @default.
• W2085207827 hasConcept C190727270 @default.
• W2085207827 hasConcept C2780192828 @default.
• W2085207827 hasConcept C33288867 @default.
• W2085207827 hasConcept C41091548 @default.
• W2085207827 hasConcept C502942594 @default.
• W2085207827 hasConcept C526805850 @default.
• W2085207827 hasConcept C530470458 @default.
• W2085207827 hasConcept C54355233 @default.
• W2085207827 hasConcept C71924100 @default.
• W2085207827 hasConcept C86803240 @default.
• W2085207827 hasConceptScore W2085207827C104317684 @default.
• W2085207827 hasConceptScore W2085207827C121608353 @default.
• W2085207827 hasConceptScore W2085207827C140173407 @default.
• W2085207827 hasConceptScore W2085207827C143998085 @default.
• W2085207827 hasConceptScore W2085207827C150194340 @default.
• W2085207827 hasConceptScore W2085207827C190727270 @default.
• W2085207827 hasConceptScore W2085207827C2780192828 @default.
• W2085207827 hasConceptScore W2085207827C33288867 @default.
• W2085207827 hasConceptScore W2085207827C41091548 @default.
• W2085207827 hasConceptScore W2085207827C502942594 @default.
• W2085207827 hasConceptScore W2085207827C526805850 @default.
• W2085207827 hasConceptScore W2085207827C530470458 @default.
• W2085207827 hasConceptScore W2085207827C54355233 @default.
• W2085207827 hasConceptScore W2085207827C71924100 @default.
• W2085207827 hasConceptScore W2085207827C86803240 @default.
• W2085207827 hasIssue "4" @default.

• next