Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085207934> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2085207934 abstract "The genesis of the Local Field Potential (LFP) highly depends on the electric properties of the extracellular medium, but such properties are still subject to a controversy because of contradictory measurements. One possibility is that the use of metal electrodes as current sources in previous studies provides non-physiological results. We tested this possibility by performing impedance measurements in conditions as close as possible to physiological conditions. We generated single-cell LFPs by injecting subthreshold inputs in single neurons using patch-clamp recordings, combined with extracellular recordings with micropipettes. Various measurement configurations show that (1) the extracellular medium has strong low-pass filtering properties and cannot be accounted by a resistive medium; (2) the frequency scaling of the filtering, as well as its phase, show that the system seems intermediate between resistive and capacitive. The extracellular impedance was also measured from in vivo experiments in rats under anesthesia. In this case, recording with intracellular (whole-cell) electrodes, together with extracellular LFP, showed results consistent with the in vitro experiments. Finally, we developed a theoretical model based on Maxwell equations, which shows that all measurements can be explained if the extracellular medium is of diffusive type (Warburg impedance). This model predicts that the phase difference between intracellular and extracellular signals should provide a signature of the physical nature of the impedance, with 45 degrees phase difference for purely diffusive type. The experiments show that indeed, the phase is that of a RC soma in series with a diffusive impedance (between 0 and -45 degrees), therefore confirming the diffusive nature of the extracellular impedance. These findings have potentially important consequences for interpreting LFP measurements and source estimation such as CSD analysis." @default.
- W2085207934 created "2016-06-24" @default.
- W2085207934 creator A5006713188 @default.
- W2085207934 creator A5017713458 @default.
- W2085207934 creator A5022027790 @default.
- W2085207934 creator A5041939772 @default.
- W2085207934 creator A5043790460 @default.
- W2085207934 creator A5053160401 @default.
- W2085207934 creator A5058542116 @default.
- W2085207934 creator A5082071331 @default.
- W2085207934 creator A5091509861 @default.
- W2085207934 date "2014-07-01" @default.
- W2085207934 modified "2023-10-18" @default.
- W2085207934 title "Microscale impedance measurements suggest that ionic diffusion is implicated in generating extracellular potentials" @default.
- W2085207934 doi "https://doi.org/10.1186/1471-2202-15-s1-p214" @default.
- W2085207934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4126426" @default.
- W2085207934 hasPublicationYear "2014" @default.
- W2085207934 type Work @default.
- W2085207934 sameAs 2085207934 @default.
- W2085207934 citedByCount "2" @default.
- W2085207934 countsByYear W20852079342015 @default.
- W2085207934 countsByYear W20852079342016 @default.
- W2085207934 crossrefType "journal-article" @default.
- W2085207934 hasAuthorship W2085207934A5006713188 @default.
- W2085207934 hasAuthorship W2085207934A5017713458 @default.
- W2085207934 hasAuthorship W2085207934A5022027790 @default.
- W2085207934 hasAuthorship W2085207934A5041939772 @default.
- W2085207934 hasAuthorship W2085207934A5043790460 @default.
- W2085207934 hasAuthorship W2085207934A5053160401 @default.
- W2085207934 hasAuthorship W2085207934A5058542116 @default.
- W2085207934 hasAuthorship W2085207934A5082071331 @default.
- W2085207934 hasAuthorship W2085207934A5091509861 @default.
- W2085207934 hasBestOaLocation W20852079341 @default.
- W2085207934 hasConcept C121332964 @default.
- W2085207934 hasConcept C12554922 @default.
- W2085207934 hasConcept C145148216 @default.
- W2085207934 hasConcept C145420912 @default.
- W2085207934 hasConcept C15744967 @default.
- W2085207934 hasConcept C159467904 @default.
- W2085207934 hasConcept C169760540 @default.
- W2085207934 hasConcept C17829176 @default.
- W2085207934 hasConcept C178790620 @default.
- W2085207934 hasConcept C179428855 @default.
- W2085207934 hasConcept C185592680 @default.
- W2085207934 hasConcept C2182769 @default.
- W2085207934 hasConcept C28406088 @default.
- W2085207934 hasConcept C55493867 @default.
- W2085207934 hasConcept C62520636 @default.
- W2085207934 hasConcept C69357855 @default.
- W2085207934 hasConcept C86803240 @default.
- W2085207934 hasConcept C97355855 @default.
- W2085207934 hasConceptScore W2085207934C121332964 @default.
- W2085207934 hasConceptScore W2085207934C12554922 @default.
- W2085207934 hasConceptScore W2085207934C145148216 @default.
- W2085207934 hasConceptScore W2085207934C145420912 @default.
- W2085207934 hasConceptScore W2085207934C15744967 @default.
- W2085207934 hasConceptScore W2085207934C159467904 @default.
- W2085207934 hasConceptScore W2085207934C169760540 @default.
- W2085207934 hasConceptScore W2085207934C17829176 @default.
- W2085207934 hasConceptScore W2085207934C178790620 @default.
- W2085207934 hasConceptScore W2085207934C179428855 @default.
- W2085207934 hasConceptScore W2085207934C185592680 @default.
- W2085207934 hasConceptScore W2085207934C2182769 @default.
- W2085207934 hasConceptScore W2085207934C28406088 @default.
- W2085207934 hasConceptScore W2085207934C55493867 @default.
- W2085207934 hasConceptScore W2085207934C62520636 @default.
- W2085207934 hasConceptScore W2085207934C69357855 @default.
- W2085207934 hasConceptScore W2085207934C86803240 @default.
- W2085207934 hasConceptScore W2085207934C97355855 @default.
- W2085207934 hasIssue "S1" @default.
- W2085207934 hasLocation W20852079341 @default.
- W2085207934 hasLocation W20852079342 @default.
- W2085207934 hasLocation W20852079343 @default.
- W2085207934 hasOpenAccess W2085207934 @default.
- W2085207934 hasPrimaryLocation W20852079341 @default.
- W2085207934 hasRelatedWork W1982845176 @default.
- W2085207934 hasRelatedWork W2010735002 @default.
- W2085207934 hasRelatedWork W2071268172 @default.
- W2085207934 hasRelatedWork W2075656461 @default.
- W2085207934 hasRelatedWork W2078748796 @default.
- W2085207934 hasRelatedWork W2127102330 @default.
- W2085207934 hasRelatedWork W2525706605 @default.
- W2085207934 hasRelatedWork W4281742532 @default.
- W2085207934 hasRelatedWork W4309432724 @default.
- W2085207934 hasRelatedWork W4376870998 @default.
- W2085207934 hasVolume "15" @default.
- W2085207934 isParatext "false" @default.
- W2085207934 isRetracted "false" @default.
- W2085207934 magId "2085207934" @default.
- W2085207934 workType "article" @default.