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- W2085219914 abstract "Abstract The cardiac effects of adenosine and quinacrine were investigated in anesthetized rats, cats and dogs. The cardiac slowing and atrioventricular block induced by iv injection of adenosine were reduced by the prior administration of quinacrine. However, the depression of myocardial contractility, decrease in coronary vascular resistance, increase in pulmonary vascular resistance and systemic hypotension induced by adenosine were not influenced by quinacrine. It is therefore unlikely that the cardiac effects of quinacrine are largely mediated by antagonizing adenosine. The depression of ventricular function produced by quinacrine is unrelated to any interaction with adenosine. The antiarrhythmic activity of primaquine, pentaquine, isopentaquine and pamaquine was demonstrated in mice. Ventricular fibrillation likely to be induced by chloroform inhalation was prevented by pretreatment with one of the 8-aminoquinolines. Primaquine antagonized some of the cardiac effects of adenosine (bradycardia and atrioventricular block) in the rat heart. Primaquine also depressed myocardial contractility and the β-adrenergic receptors in the canine heart." @default.
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- W2085219914 date "1972-04-01" @default.
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- W2085219914 title "Cardiopulmonary effects of antimalarial drugs" @default.
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- W2085219914 doi "https://doi.org/10.1016/0041-008x(72)90004-x" @default.
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