FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085221388> ?p ?o ?g. }

• W2085221388 endingPage "88" @default.
• W2085221388 startingPage "73" @default.
• W2085221388 abstract "Aging is associated with a reduced ability to cope with physiological challenges. Although the mechanisms underlying age-related alterations in stress tolerance are not well defined, many studies support the validity of the oxidative stress hypothesis, which suggests that lowered functional capacity in aged organisms is the result of an increased generation of reactive oxygen and nitrogen species. Increased production of oxidants in vivo can cause damage to intracellular macromolecules, which can translate into oxidative injury, impaired function and cell death in vulnerable tissues such as the brain. To survive different types of injuries, brain cells have evolved networks of responses, which detect and control diverse forms of stress. This is accomplished by a complex network of the so-called longevity assurance processes, which are composed of several genes termed vitagenes. Among these, heat shock proteins form a highly conserved system responsible for the preservation and repair of the correct protein conformation. The heat shock response contributes to establishing a cytoprotective state in a wide variety of human diseases, including inflammation, cancer, aging and neurodegenerative disorders. Given the broad cytoprotective properties of the heat shock response, there is now a strong interest in discovering and developing pharmacological agents capable of inducing the heat shock response. Acetylcarnitine is proposed as a therapeutic agent for several neurodegenerative disorders, and there is now evidence that it may play a critical role as modulator of cellular stress response in health and disease states. In the present review, we first discuss the role of nutrition in carnitine metabolism, followed by a discussion of carnitine and acetyl-l-carnitine in mitochondrial dysfunction, in aging, and in age-related disorders. We then review the evidence for the role of acetylcarnitine in modulating redox-dependent mechanisms leading to up-regulation of vitagenes in brain, and we also discuss new approaches for investigating the mechanisms of lifetime survival and longevity." @default.
• W2085221388 created "2016-06-24" @default.
• W2085221388 creator A5004024175 @default.
• W2085221388 creator A5043818252 @default.
• W2085221388 creator A5053592791 @default.
• W2085221388 creator A5076362800 @default.
• W2085221388 date "2006-02-01" @default.
• W2085221388 modified "2023-10-15" @default.
• W2085221388 title "Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes" @default.
• W2085221388 cites W128409644 @default.
• W2085221388 cites W136375453 @default.
• W2085221388 cites W13871583 @default.
• W2085221388 cites W1499645177 @default.
• W2085221388 cites W150378829 @default.
• W2085221388 cites W1508644246 @default.
• W2085221388 cites W1523213544 @default.
• W2085221388 cites W1545799264 @default.
• W2085221388 cites W1565127991 @default.
• W2085221388 cites W1583148430 @default.
• W2085221388 cites W1595816980 @default.
• W2085221388 cites W1758143390 @default.
• W2085221388 cites W1819087145 @default.
• W2085221388 cites W1843994302 @default.
• W2085221388 cites W1862533548 @default.
• W2085221388 cites W1922292712 @default.
• W2085221388 cites W192344899 @default.
• W2085221388 cites W1963500709 @default.
• W2085221388 cites W1963676888 @default.
• W2085221388 cites W1964722038 @default.
• W2085221388 cites W1966703352 @default.
• W2085221388 cites W1969115426 @default.
• W2085221388 cites W1973254364 @default.
• W2085221388 cites W1973819921 @default.
• W2085221388 cites W1975515966 @default.
• W2085221388 cites W1976364159 @default.
• W2085221388 cites W1980920477 @default.
• W2085221388 cites W1981704160 @default.
• W2085221388 cites W1982779053 @default.
• W2085221388 cites W1982872396 @default.
• W2085221388 cites W1983025747 @default.
• W2085221388 cites W1983934640 @default.
• W2085221388 cites W1984620545 @default.
• W2085221388 cites W1986525923 @default.
• W2085221388 cites W1988668221 @default.
• W2085221388 cites W1988721068 @default.
• W2085221388 cites W1991824137 @default.
• W2085221388 cites W1992915382 @default.
• W2085221388 cites W1993367492 @default.
• W2085221388 cites W1995486038 @default.
• W2085221388 cites W1998722744 @default.
• W2085221388 cites W2000037917 @default.
• W2085221388 cites W2001070206 @default.
• W2085221388 cites W2001483373 @default.
• W2085221388 cites W2005250105 @default.
• W2085221388 cites W2007486805 @default.
• W2085221388 cites W2007814471 @default.
• W2085221388 cites W2008537564 @default.
• W2085221388 cites W2009305332 @default.
• W2085221388 cites W2012770842 @default.
• W2085221388 cites W2015832516 @default.
• W2085221388 cites W2016255597 @default.
• W2085221388 cites W2018118901 @default.
• W2085221388 cites W2018474491 @default.
• W2085221388 cites W2018500024 @default.
• W2085221388 cites W2020941408 @default.
• W2085221388 cites W2021195481 @default.
• W2085221388 cites W2026859315 @default.
• W2085221388 cites W2026982245 @default.
• W2085221388 cites W2029466872 @default.
• W2085221388 cites W2030885185 @default.
• W2085221388 cites W2031476702 @default.
• W2085221388 cites W2032124050 @default.
• W2085221388 cites W2033279283 @default.
• W2085221388 cites W2034716956 @default.
• W2085221388 cites W2039330812 @default.
• W2085221388 cites W2039540766 @default.
• W2085221388 cites W2043620869 @default.
• W2085221388 cites W2044627978 @default.
• W2085221388 cites W2045231811 @default.
• W2085221388 cites W2046838044 @default.
• W2085221388 cites W2047412657 @default.
• W2085221388 cites W2049468662 @default.
• W2085221388 cites W2049550781 @default.
• W2085221388 cites W2052203707 @default.
• W2085221388 cites W2052232849 @default.
• W2085221388 cites W2052807450 @default.
• W2085221388 cites W2055801667 @default.
• W2085221388 cites W2056206142 @default.
• W2085221388 cites W2056523101 @default.
• W2085221388 cites W2060916730 @default.
• W2085221388 cites W2061802371 @default.
• W2085221388 cites W2065284764 @default.
• W2085221388 cites W2065370260 @default.
• W2085221388 cites W2067725853 @default.
• W2085221388 cites W2072059377 @default.
• W2085221388 cites W2073845259 @default.
• W2085221388 cites W2074232475 @default.
• W2085221388 cites W2075612514 @default.

• next