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• W2085221466 abstract "In our view, the idea that hexokinase might be involved in sugar sensing via a direct signaling role, rather than in its known metabolic role, remains a hypothesis and not an established fact. However, we thank Brandon Moore and Jen Sheen for their balanced response to our article1xIs hexokinase really a sugar sensor in plants?. Halford, N.G., Purcell, P.C., and Hardie, D.G. Trends Plant Sci. 1999; 4: 117–120Abstract | Full Text | Full Text PDF | PubMed | Scopus (104)See all References1. Our intention was not to criticize the previous studies, but rather to act as devil's advocate, as we felt that it was important that researchers did not dismiss other possible mechanisms of sugar sensing.To respond to the three main lines of evidence in the preceding correspondence: (1) Over-expression of yeast HXK2 in Arabidopsis resulted in elevated hexokinase activity measured in an extract2xHexokinase as a sugar sensor in higher plants. Jang, J-C. et al. Plant Cell. 1997; 9: 5–19PubMedSee all References2, but it was not shown that it increased glucose metabolism per se. (2) The recent paper by Sjef Smeekens' group3xMannose inhibits Arabidopsis germination via a hexokinase-mediated step. Pego, J.V., Weisbeek, P.J., and Smeekens, S.C.M. Plant Physiol. 1999; 119: 1017–1023Crossref | PubMedSee all References3 was not available when we wrote our article, but we agree that it appears to overcome our objection that slowly metabolizable sugars might cause ATP depletion. (3) We remain sceptical about experiments where glucose-6-phosphate (G6P) was introduced into maize protoplasts by electroporation4xSugar sensing in higher plants. Jang, J-C. and Sheen, J. Plant Cell. 1994; 6: 1665–1679PubMedSee all References4. Although it was claimed that this caused a small (∼30%) sustained increase in cellular G6P, it seems inconceivable to us that the G6P that entered would remain unmetabolized for 3 h. It also seems unwise to compare results obtained after electroporation of G6P and glucose, because the former could only enter during the brief period when the electroporation pores were open, whereas the latter would continue to enter by normal transport processes after the pores had sealed.We also take issue with two further points. A role for SnRK1 (or SNF1 for that matter) in sugar sensing does not preclude a role for hexokinase, and the demonstration that antisense expression of an SnRK1 sequence in potato tubers affected sucrose synthase gene expression5xAntisense expression of a sucrose non-fermenting-1-related protein kinase sequence in potato results in decreased expression of sucrose synthase in tubers and loss of sucrose-inducibility of sucrose synthase transcripts in leaves. Purcell, P.C., Smith, A.M., and Halford, N.G. Plant J. 1998; 14: 195–202Crossref | Scopus (139)See all References5 does not imply that sucrose synthase is the only gene controlled by SnRK1.In conclusion, we agree that plants might have multiple pathways for sensing sugars, and that these might differ from those present in yeast. However, we will retain a healthy scepticism about the signaling role of hexokinase until the putative pathway that links it to gene expression is identified. If someone can achieve this, we will be the first to congratulate them." @default.
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• W2085221466 title "Reply…The sugar sensing story" @default.
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