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- W2085223462 abstract "Although mu opioid (MOP) receptor agonists are the most commonly used analgesics for the treatment of moderate to severe pain in the clinic, the side effects of MOP agonists such as abuse liability limit their value as a medication. Research to identify novel analgesics without adverse effects is pivotal to advance the health care of humans. The nociceptin/orphanin FQ peptide (NOP) receptor, the fourth opioid receptor subtype, mediates distinctive actions in nonhuman primates which suggests the possibility that activity at this receptor may result in strong analgesia in the absence of virtually all of the side effects associated with MOP agonists. The present review highlights the recent progress of pharmacological studies of NOP-related ligands in primates. Selective NOP agonists, either peptidic or nonpeptidic, produce full analgesia in various assays in primates, when delivered systemically or intrathecally. Yet small molecule NOP agonists do not serve as reinforcers, indicating a lack of abuse liability. Given that NOP agonists have low abuse liability and that coactivation of NOP and MOP receptors produces synergistic antinociception, it is worth developing bifunctional NOP/MOP ligands. The outcomes of these studies and recent developments provide new perspectives to establish a translational bridge for understanding the biobehavioral functions of NOP receptors in primates and for facilitating the development of NOP-related ligands as a new generation of analgesics without abuse liability in humans." @default.
- W2085223462 created "2016-06-24" @default.
- W2085223462 creator A5083646280 @default.
- W2085223462 creator A5086697851 @default.
- W2085223462 date "2012-11-06" @default.
- W2085223462 modified "2023-10-14" @default.
- W2085223462 title "The Therapeutic Potential of Nociceptin/Orphanin FQ Receptor Agonists as Analgesics without Abuse Liability" @default.
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- W2085223462 doi "https://doi.org/10.1021/cn300124f" @default.
- W2085223462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3582300" @default.
- W2085223462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23421672" @default.
- W2085223462 hasPublicationYear "2012" @default.