Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085224764> ?p ?o ?g. }
- W2085224764 endingPage "997" @default.
- W2085224764 startingPage "990" @default.
- W2085224764 abstract "The Ever shorter telomeres 3 (Est3) protein is a small regulatory subunit of yeast telomerase which is dispensable for enzyme catalysis but essential for telomere replication in vivo. Using structure prediction combined with in vivo characterization, we show here that Est3 consists of a predicted OB (oligosaccharide/oligonucleotide binding)-fold. We used mutagenesis of predicted surface residues to generate a functional map of one surface of Est3, identifying a site that mediates association with the telomerase complex. Unexpectedly, the predicted OB-fold of Est3 is structurally similar to the OB-fold of the human TPP1 protein, despite the fact that Est3 and TPP1, as components of telomerase and a telomere-capping complex, respectively, perform functionally distinct tasks at chromosome ends. Our analysis of Est3 may be instructive in generating comparable missense mutations on the surface of the OB-fold domain of TPP1." @default.
- W2085224764 created "2016-06-24" @default.
- W2085224764 creator A5026740248 @default.
- W2085224764 creator A5043273992 @default.
- W2085224764 creator A5070821846 @default.
- W2085224764 creator A5076071801 @default.
- W2085224764 creator A5080227269 @default.
- W2085224764 date "2008-08-24" @default.
- W2085224764 modified "2023-10-14" @default.
- W2085224764 title "The Est3 protein associates with yeast telomerase through an OB-fold domain" @default.
- W2085224764 cites W1577250214 @default.
- W2085224764 cites W1948628402 @default.
- W2085224764 cites W1965213816 @default.
- W2085224764 cites W1965303630 @default.
- W2085224764 cites W1971933667 @default.
- W2085224764 cites W1977780474 @default.
- W2085224764 cites W1984556339 @default.
- W2085224764 cites W1984700926 @default.
- W2085224764 cites W1985910710 @default.
- W2085224764 cites W1985964699 @default.
- W2085224764 cites W1986659195 @default.
- W2085224764 cites W1988669405 @default.
- W2085224764 cites W1998405157 @default.
- W2085224764 cites W2003446723 @default.
- W2085224764 cites W2004228538 @default.
- W2085224764 cites W2004561527 @default.
- W2085224764 cites W2010975156 @default.
- W2085224764 cites W2011862425 @default.
- W2085224764 cites W2011882274 @default.
- W2085224764 cites W2018009271 @default.
- W2085224764 cites W2022920512 @default.
- W2085224764 cites W2022959766 @default.
- W2085224764 cites W2032149581 @default.
- W2085224764 cites W2033297272 @default.
- W2085224764 cites W2038383843 @default.
- W2085224764 cites W2043740004 @default.
- W2085224764 cites W2052786131 @default.
- W2085224764 cites W2065283382 @default.
- W2085224764 cites W2075626800 @default.
- W2085224764 cites W2080781191 @default.
- W2085224764 cites W2082667898 @default.
- W2085224764 cites W2083569841 @default.
- W2085224764 cites W2099590298 @default.
- W2085224764 cites W2106311785 @default.
- W2085224764 cites W2109254920 @default.
- W2085224764 cites W2110397834 @default.
- W2085224764 cites W2125194621 @default.
- W2085224764 cites W2129696543 @default.
- W2085224764 cites W2130283365 @default.
- W2085224764 cites W2130525093 @default.
- W2085224764 cites W2131549919 @default.
- W2085224764 cites W2135668486 @default.
- W2085224764 cites W2137261276 @default.
- W2085224764 cites W2140101719 @default.
- W2085224764 cites W2144417959 @default.
- W2085224764 cites W2155201844 @default.
- W2085224764 cites W2155983703 @default.
- W2085224764 cites W2156563976 @default.
- W2085224764 cites W2159280460 @default.
- W2085224764 cites W2165580070 @default.
- W2085224764 doi "https://doi.org/10.1038/nsmb.1472" @default.
- W2085224764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2669685" @default.
- W2085224764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19172754" @default.
- W2085224764 hasPublicationYear "2008" @default.
- W2085224764 type Work @default.
- W2085224764 sameAs 2085224764 @default.
- W2085224764 citedByCount "53" @default.
- W2085224764 countsByYear W20852247642012 @default.
- W2085224764 countsByYear W20852247642013 @default.
- W2085224764 countsByYear W20852247642014 @default.
- W2085224764 countsByYear W20852247642015 @default.
- W2085224764 countsByYear W20852247642017 @default.
- W2085224764 countsByYear W20852247642018 @default.
- W2085224764 countsByYear W20852247642020 @default.
- W2085224764 countsByYear W20852247642023 @default.
- W2085224764 crossrefType "journal-article" @default.
- W2085224764 hasAuthorship W2085224764A5026740248 @default.
- W2085224764 hasAuthorship W2085224764A5043273992 @default.
- W2085224764 hasAuthorship W2085224764A5070821846 @default.
- W2085224764 hasAuthorship W2085224764A5076071801 @default.
- W2085224764 hasAuthorship W2085224764A5080227269 @default.
- W2085224764 hasBestOaLocation W20852247642 @default.
- W2085224764 hasConcept C104292427 @default.
- W2085224764 hasConcept C104317684 @default.
- W2085224764 hasConcept C153911025 @default.
- W2085224764 hasConcept C177336024 @default.
- W2085224764 hasConcept C202265312 @default.
- W2085224764 hasConcept C501734568 @default.
- W2085224764 hasConcept C54355233 @default.
- W2085224764 hasConcept C552990157 @default.
- W2085224764 hasConcept C55468747 @default.
- W2085224764 hasConcept C55493867 @default.
- W2085224764 hasConcept C58337764 @default.
- W2085224764 hasConcept C73573662 @default.
- W2085224764 hasConcept C75563809 @default.
- W2085224764 hasConcept C86339819 @default.
- W2085224764 hasConcept C86803240 @default.
- W2085224764 hasConcept C94581717 @default.