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- W2085226002 abstract "Molecular targeted therapy represents a promising new strategy for treating cancers because many small-molecule inhibitors targeting protein kinases have recently become available. Reverse-phase protein microarrays (RPPAs) are a useful platform for identifying dysregulated signaling pathways in tumors and can provide insight into patient-specific differences. In the present study, RPPAs were used to examine 60 protein end points (predominantly phosphoproteins) in matched tumor and nonmalignant biopsy specimens from 23 patients with head and neck squamous cell carcinoma to characterize the cancer phosphoproteome. RPPA identified 18 of 60 analytes globally elevated in tumors versus healthy tissue and 17 of 60 analytes that were decreased. The most significantly elevated analytes in tumor were checkpoint kinase (Chk) 1 serine 345 (S345), Chk 2 S33/35, eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) S65, protein kinase C (PKC) ζ/ι threonine 410/412 (T410/T412), LKB1 S334, inhibitor of kappaB alpha (IκB-α) S32, eukaryotic translation initiation factor 4E (eIF4E) S209, Smad2 S465/67, insulin receptor substrate 1 (IRS-1) S612, mitogen-activated ERK kinase 1/2 (MEK1/2) S217/221, and total PKC ι. To our knowledge, this is the first report of elevated PKC ι in head and neck squamous cell carcinoma that may have significance because PKC ι is an oncogene in several other tumor types, including lung cancer. The feasibility of using RPPA for developing theranostic tests to guide personalized therapy is discussed in the context of these data." @default.
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- W2085226002 date "2011-02-01" @default.
- W2085226002 modified "2023-10-14" @default.
- W2085226002 title "Phosphoproteomic Analysis of Signaling Pathways in Head and Neck Squamous Cell Carcinoma Patient Samples" @default.
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- W2085226002 cites W1964675052 @default.
- W2085226002 cites W1966265295 @default.
- W2085226002 cites W1970159404 @default.
- W2085226002 cites W1977651481 @default.
- W2085226002 cites W1981657616 @default.
- W2085226002 cites W1983340023 @default.
- W2085226002 cites W1992226313 @default.
- W2085226002 cites W1993860023 @default.
- W2085226002 cites W2009334489 @default.
- W2085226002 cites W2010614361 @default.
- W2085226002 cites W2013470066 @default.
- W2085226002 cites W2016503230 @default.
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- W2085226002 cites W2024377014 @default.
- W2085226002 cites W2025504025 @default.
- W2085226002 cites W2026644511 @default.
- W2085226002 cites W2028062404 @default.
- W2085226002 cites W2030306658 @default.
- W2085226002 cites W2033485661 @default.
- W2085226002 cites W2036363901 @default.
- W2085226002 cites W2040863351 @default.
- W2085226002 cites W2046525768 @default.
- W2085226002 cites W2049572301 @default.
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- W2085226002 cites W2053577165 @default.
- W2085226002 cites W2054379052 @default.
- W2085226002 cites W2059971436 @default.
- W2085226002 cites W2065946919 @default.
- W2085226002 cites W2073229919 @default.
- W2085226002 cites W2083741449 @default.
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- W2085226002 cites W2116401711 @default.
- W2085226002 cites W2118266991 @default.
- W2085226002 cites W2121404525 @default.
- W2085226002 cites W2123326378 @default.
- W2085226002 cites W2129615992 @default.
- W2085226002 cites W2146950496 @default.
- W2085226002 cites W2146989813 @default.
- W2085226002 cites W2147191052 @default.
- W2085226002 cites W2149412903 @default.
- W2085226002 cites W2154376727 @default.
- W2085226002 cites W2157946848 @default.
- W2085226002 cites W2169785524 @default.
- W2085226002 cites W2170487900 @default.
- W2085226002 cites W2411566683 @default.
- W2085226002 cites W4236389247 @default.
- W2085226002 cites W4254985403 @default.
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- W2085226002 doi "https://doi.org/10.1016/j.ajpath.2010.10.044" @default.
- W2085226002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3070553" @default.
- W2085226002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21281788" @default.
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