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- W2085226443 abstract "Different cytokines have been suggested to be involved in the pathogenesis of pulmonary tuberculosis (TB). The frequencies of Mycobacterium tuberculosis (MTB) specific CD4+ and CD8+ T cells, CD4+CD25+ Forkhead Box Protein (FoxP)3+ T cells, interleukin (IL)-6, interferon (IFN)-γ, Tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β and IL-10 were assessed in HIV-negative, pulmonary tuberculosis (TB) patients (n = 30) and in healthy controls (n = 23) in Gabon. Peripheral blood mononuclear cells (PBMC) were stimulated with purified protein derivative (PPD) and early secretory antigenic target-6 (ESAT-6). In patients, a pronounced pro-inflammatory cytokine response with highly significant increased levels of IL-6 and TNF-α accompanied by increased TGF-β was detectable. Differences in IFN-γ responses between patients and healthy individuals were less pronounced than expected. FoxP3 expression did not differ between groups. A distinct cytokine pattern is associated with active pulmonary TB in patients from Central Africa." @default.
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- W2085226443 date "2011-01-01" @default.
- W2085226443 modified "2023-10-18" @default.
- W2085226443 title "Specific cytokine patterns of pulmonary tuberculosis in Central Africa" @default.
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- W2085226443 doi "https://doi.org/10.1016/j.clim.2010.09.005" @default.
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