FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085227055> ?p ?o ?g. }

• W2085227055 endingPage "40" @default.
• W2085227055 startingPage "34" @default.
• W2085227055 abstract "Matrix metalloproteinases (MMPs) are considered candidate biomarkers for both physiological and pathological tissue remodelling because of their key role in articular cartilage homeostasis. As disruption of the collagenous architecture is thought to be pivotal in chronic degenerative diseases such as osteoarthritis (OA), the collagenases form an interesting subset of the MMPs. The significance of any biomarker in synovial fluid (SF) can be assessed properly only when fluctuations in patterns induced by physiological processes such as development and growth, and by external influences and interventions such as exercise and repeated arthrocentesis, are known and taken into account.To investigate the activity of MMP-1 in equine SF at different stages of development and in joints affected by OA, and the influence of exercise and repeated arthrocentesis thereon.MMP-1 activity was determined in SF of normal joints of fetal, juvenile and mature horses, and in SF of horses suffering from OA, using an internally quenched fluorogenic peptide substrate. MMP-1 activity was also measured in SF from horses subjected to an exercise regimen and those subjected to repeated arthrocentesis.An age-related decline in the SF levels of active MMP-1 was observed. MMP-1 activity was 15-fold higher in fetal than in juvenile animals, which showed significantly higher MMP-1 activity levels than mature horses. In SF of OA joints, MMP-1 activity was increased. Exercise did not affect MMP-1 activity in SF, but repeated arthrocentesis (within 60 h) increased MMP-1 activity significantly.The high MMP-1 activity in SF of young individuals parallels the high metabolic activity occurring during rapid growth and differentiation at early age. The elevated MMP-1 activity in SF of OA joints probably reflects pathological matrix degradation, confirming the potential of MMP-1 to serve as a biochemical marker for early joint disease. Moderate exercise is not likely to influence the outcome of MMP-1 activity measurements in equine SF, but arthrocentesis should be taken into account as a possible confounding factor.Given the crucial role of the collagen matrix for tissue integrity, MMP-1 activity may be a useful tool in diagnostic, therapeutic or prognostic studies in horses suspected of OA. However, care should be taken to exclude fluctuations in MMP-1 activity induced by physiological processes such as development and growth, and by interventions such as repeated arthrocentesis." @default.
• W2085227055 created "2016-06-24" @default.
• W2085227055 creator A5064730734 @default.
• W2085227055 creator A5067150314 @default.
• W2085227055 creator A5085468214 @default.
• W2085227055 creator A5086269203 @default.
• W2085227055 creator A5087791380 @default.
• W2085227055 date "2010-01-05" @default.
• W2085227055 modified "2023-10-01" @default.
• W2085227055 title "Collagenase-1 (MMP-1) activity in equine synovial fluid: influence of age, joint pathology, exercise and repeated arthrocentesis" @default.
• W2085227055 cites W1593295279 @default.
• W2085227055 cites W1762318613 @default.
• W2085227055 cites W1894541755 @default.
• W2085227055 cites W1970680464 @default.
• W2085227055 cites W1972861978 @default.
• W2085227055 cites W1976442568 @default.
• W2085227055 cites W1977489967 @default.
• W2085227055 cites W1979915035 @default.
• W2085227055 cites W1979972616 @default.
• W2085227055 cites W1980480613 @default.
• W2085227055 cites W1986768873 @default.
• W2085227055 cites W1993197671 @default.
• W2085227055 cites W1995304518 @default.
• W2085227055 cites W2014636270 @default.
• W2085227055 cites W2014972722 @default.
• W2085227055 cites W2022749981 @default.
• W2085227055 cites W2031001505 @default.
• W2085227055 cites W2032361352 @default.
• W2085227055 cites W2037282117 @default.
• W2085227055 cites W2044110442 @default.
• W2085227055 cites W2046331668 @default.
• W2085227055 cites W2047636197 @default.
• W2085227055 cites W2052548291 @default.
• W2085227055 cites W2054221638 @default.
• W2085227055 cites W2054989822 @default.
• W2085227055 cites W2058721833 @default.
• W2085227055 cites W2063405742 @default.
• W2085227055 cites W2067161511 @default.
• W2085227055 cites W2070949132 @default.
• W2085227055 cites W2072445803 @default.
• W2085227055 cites W2073456348 @default.
• W2085227055 cites W2077679509 @default.
• W2085227055 cites W2078477725 @default.
• W2085227055 cites W2082812095 @default.
• W2085227055 cites W2086096794 @default.
• W2085227055 cites W2087628254 @default.
• W2085227055 cites W2098076093 @default.
• W2085227055 cites W2120347240 @default.
• W2085227055 cites W2127874165 @default.
• W2085227055 cites W2135124706 @default.
• W2085227055 cites W2138960046 @default.
• W2085227055 cites W2143164371 @default.
• W2085227055 cites W2152217106 @default.
• W2085227055 cites W2432056437 @default.
• W2085227055 cites W2484223204 @default.
• W2085227055 cites W4250908540 @default.
• W2085227055 cites W4253061146 @default.
• W2085227055 doi "https://doi.org/10.2746/0425164044864705" @default.
• W2085227055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14756369" @default.
• W2085227055 hasPublicationYear "2010" @default.
• W2085227055 type Work @default.
• W2085227055 sameAs 2085227055 @default.
• W2085227055 citedByCount "62" @default.
• W2085227055 countsByYear W20852270552012 @default.
• W2085227055 countsByYear W20852270552013 @default.
• W2085227055 countsByYear W20852270552014 @default.
• W2085227055 countsByYear W20852270552015 @default.
• W2085227055 countsByYear W20852270552016 @default.
• W2085227055 countsByYear W20852270552017 @default.
• W2085227055 countsByYear W20852270552019 @default.
• W2085227055 countsByYear W20852270552020 @default.
• W2085227055 countsByYear W20852270552021 @default.
• W2085227055 countsByYear W20852270552023 @default.
• W2085227055 crossrefType "journal-article" @default.
• W2085227055 hasAuthorship W2085227055A5064730734 @default.
• W2085227055 hasAuthorship W2085227055A5067150314 @default.
• W2085227055 hasAuthorship W2085227055A5085468214 @default.
• W2085227055 hasAuthorship W2085227055A5086269203 @default.
• W2085227055 hasAuthorship W2085227055A5087791380 @default.
• W2085227055 hasConcept C105702510 @default.
• W2085227055 hasConcept C109523444 @default.
• W2085227055 hasConcept C126322002 @default.
• W2085227055 hasConcept C134018914 @default.
• W2085227055 hasConcept C142724271 @default.
• W2085227055 hasConcept C151730666 @default.
• W2085227055 hasConcept C181199279 @default.
• W2085227055 hasConcept C185592680 @default.
• W2085227055 hasConcept C204787440 @default.
• W2085227055 hasConcept C2776164576 @default.
• W2085227055 hasConcept C2776268809 @default.
• W2085227055 hasConcept C2777732084 @default.
• W2085227055 hasConcept C2778394429 @default.
• W2085227055 hasConcept C2780550940 @default.
• W2085227055 hasConcept C2780762169 @default.
• W2085227055 hasConcept C55493867 @default.
• W2085227055 hasConcept C71924100 @default.
• W2085227055 hasConcept C86803240 @default.
• W2085227055 hasConceptScore W2085227055C105702510 @default.

• next