Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085232197> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2085232197 abstract "CULTURE IN DETERMINING GROUP B STREPTOCOCCUS COLONIZATION MICHAEL GAVINO, EILEEN WANG, University of Chicago, Obstetrics and Gynecology, Chicago, Illinois OBJECTIVE: To evaluate a new rapid, real-time polymerase-chain reaction (PCR)-based assay in the intrapartum detection of Group B Streptococcus (GBS) colonization STUDY DESIGN: This is a prospective observational study where term patients were consented at the University of Chicago clinics after GBS screening at 35-37 weeks gestation. During admission for delivery, paired rectovaginal swabs were obtained–one swab for the rapid GBS assay employing the real-time PCR GeneXpert System (Cepheid, Sunnyvale, CA) with easy sample preparation, GBS target amplification and detection in a single cartridge in under 90min, the other for standard culture. The GBS carriage rate was calculated for the study population. Using the intrapartum culture as the gold standard, the sensitivities, specificities, and predictive values of the rapid GBS test and the 35-37 week culture were determined. Fisher’s exact chisquare test was used to assess for statistical significance. RESULTS: Fifty-five subjects had data from both the rapid test and intrapartum culture. The GBS colonization rate by intrapartum culture was approximately 43.6%. Compared with intrapartum culture, the rapid molecular test had a sensitivity of 95.8%, specificity of 64.5%, positive predictive value of 67.6%, and negative predictive value of 95.2% (p-values !0.0001). In addition, the real-time PCR test was more sensitive than the antenatal culture which had a sensitivity of 83.3%, a specificity of 80.6%, a positive predictive value of 76.9% and negative predictive value of 86.2%. CONCLUSION: This pilot study suggests that the GeneXpert rapid GBS test is highly sensitive for the intrapartum detection of GBS. The GBS colonization rate in this group of predominantly African American Medicaid patients was higher than generally reported. This study supports the feasibility of using this assay when the GBS status is unknown i.e. with patients without prenatal care, to allow for more selective use of antibiotic prophylaxis. A costbenefit analysis is underway to better delineate the potential implementation of this new technology." @default.
- W2085232197 created "2016-06-24" @default.
- W2085232197 creator A5050114426 @default.
- W2085232197 creator A5083886665 @default.
- W2085232197 date "2006-12-01" @default.
- W2085232197 modified "2023-09-26" @default.
- W2085232197 title "A comparison of a new rapid real-time PCR system to traditional culture in determining group B streptococcus colonization" @default.
- W2085232197 doi "https://doi.org/10.1016/j.ajog.2006.10.159" @default.
- W2085232197 hasPublicationYear "2006" @default.
- W2085232197 type Work @default.
- W2085232197 sameAs 2085232197 @default.
- W2085232197 citedByCount "0" @default.
- W2085232197 crossrefType "journal-article" @default.
- W2085232197 hasAuthorship W2085232197A5050114426 @default.
- W2085232197 hasAuthorship W2085232197A5083886665 @default.
- W2085232197 hasConcept C126265401 @default.
- W2085232197 hasConcept C126322002 @default.
- W2085232197 hasConcept C131872663 @default.
- W2085232197 hasConcept C142724271 @default.
- W2085232197 hasConcept C189539697 @default.
- W2085232197 hasConcept C2776301714 @default.
- W2085232197 hasConcept C2776927270 @default.
- W2085232197 hasConcept C2777785397 @default.
- W2085232197 hasConcept C2778276568 @default.
- W2085232197 hasConcept C2781069245 @default.
- W2085232197 hasConcept C2908647359 @default.
- W2085232197 hasConcept C29456083 @default.
- W2085232197 hasConcept C3019719930 @default.
- W2085232197 hasConcept C40993552 @default.
- W2085232197 hasConcept C523546767 @default.
- W2085232197 hasConcept C54355233 @default.
- W2085232197 hasConcept C71924100 @default.
- W2085232197 hasConcept C86803240 @default.
- W2085232197 hasConcept C89423630 @default.
- W2085232197 hasConcept C99454951 @default.
- W2085232197 hasConceptScore W2085232197C126265401 @default.
- W2085232197 hasConceptScore W2085232197C126322002 @default.
- W2085232197 hasConceptScore W2085232197C131872663 @default.
- W2085232197 hasConceptScore W2085232197C142724271 @default.
- W2085232197 hasConceptScore W2085232197C189539697 @default.
- W2085232197 hasConceptScore W2085232197C2776301714 @default.
- W2085232197 hasConceptScore W2085232197C2776927270 @default.
- W2085232197 hasConceptScore W2085232197C2777785397 @default.
- W2085232197 hasConceptScore W2085232197C2778276568 @default.
- W2085232197 hasConceptScore W2085232197C2781069245 @default.
- W2085232197 hasConceptScore W2085232197C2908647359 @default.
- W2085232197 hasConceptScore W2085232197C29456083 @default.
- W2085232197 hasConceptScore W2085232197C3019719930 @default.
- W2085232197 hasConceptScore W2085232197C40993552 @default.
- W2085232197 hasConceptScore W2085232197C523546767 @default.
- W2085232197 hasConceptScore W2085232197C54355233 @default.
- W2085232197 hasConceptScore W2085232197C71924100 @default.
- W2085232197 hasConceptScore W2085232197C86803240 @default.
- W2085232197 hasConceptScore W2085232197C89423630 @default.
- W2085232197 hasConceptScore W2085232197C99454951 @default.
- W2085232197 hasLocation W20852321971 @default.
- W2085232197 hasOpenAccess W2085232197 @default.
- W2085232197 hasPrimaryLocation W20852321971 @default.
- W2085232197 hasRelatedWork W2028642426 @default.
- W2085232197 hasRelatedWork W2126914905 @default.
- W2085232197 hasRelatedWork W2362741913 @default.
- W2085232197 hasRelatedWork W2378619282 @default.
- W2085232197 hasRelatedWork W2735691483 @default.
- W2085232197 hasRelatedWork W2786669054 @default.
- W2085232197 hasRelatedWork W2957718322 @default.
- W2085232197 hasRelatedWork W3000282141 @default.
- W2085232197 hasRelatedWork W3030834268 @default.
- W2085232197 hasRelatedWork W3197764052 @default.
- W2085232197 isParatext "false" @default.
- W2085232197 isRetracted "false" @default.
- W2085232197 magId "2085232197" @default.
- W2085232197 workType "article" @default.