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• W2085236444 endingPage "S92" @default.
• W2085236444 startingPage "S85" @default.
• W2085236444 abstract "To better understand the mechanisms by which zinc deficiency induces epithelial cell death, studies were done of the effects of intracellular zinc depletion induced by the zinc chelator TPEN on apoptosis-related events in human malignant epithelial cell lines LIM1215 (colonic), NCI-H292 (bronchial), and A549 (alveolar type II). In TPEN-treated cells, depletion of zinc was followed by activation of caspase-3 (as demonstrated by enzymatic assay and Western blotting), DNA fragmentation, and morphologic changes. Increase in caspase-3 activity began 12 h after addition of TPEN, suggesting that zinc may suppress a step just before the activation of this caspase. Caspase-6, a mediator of caspase-3 processing, also increased, but later than caspase-3. Effects of TPEN on apoptosis were completely prevented by exogenous ZnSO4 and partially prevented by peptide caspase inhibitors. A critical substrate of caspase-3 may be the cell cycle regulator p21Waf1/Cip1, which was rapidly cleaved in TPEN-treated cells to a 15-kDa fragment before further degradation." @default.
• W2085236444 created "2016-06-24" @default.
• W2085236444 creator A5037713568 @default.
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• W2085236444 date "2000-09-01" @default.
• W2085236444 modified "2023-09-25" @default.
• W2085236444 title "Intracellular Zinc Depletion Induces Caspase Activation and p21^Waf1/Cip1Cleavage in Human Epithelial Cell Lines" @default.
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• W2085236444 doi "https://doi.org/10.1086/315914" @default.
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