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• W2085236872 abstract "The presence of GAB Aergic innervation in cerebral arteries of several species was investigated by an immunohistochemical method using antibodies against glutamic acid decarboxylase (GAD) and GABA transaminase (GABA-T). Both GAD and GABA-T immunoreactivities were found to be associated with large bundles and single fibers in the adventitial layer of arteries examined. The density and distribution pattern of both GAD-and GABA-T-immunoreactive fibers were found to be comparable at most regions examined. Both fibers were found to be most dense in the anterior cerebral artery and its adjacent part of the circle of Willis. Several peripheral arteries were found to receive very sparse or no GAD-and GABA-T-immunoreactive fibers. Superior cervical ganglionectomy did not appreciably affect the distribution of both fibers. Cold-storage denervation, however, resulted in a drastic decrease in both fibers. At ultrastructural levels, both GAD- and GABA-T-immunoreactive nerve profiles were found to be very close to the smooth muscle cells. These results demonstrate the presence of a potentially functional GAB Aergic innervation in cerebral circulation. On few occasions, GAD immunoreactivities were also found in some endothelial cells, suggesting that a nonneuronal GABA system may also be present in cerebral arteries." @default.
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• W2085236872 date "1991-01-01" @default.
• W2085236872 modified "2023-10-16" @default.
• W2085236872 title "GAB Aergic Innervation in Cerebral Blood Vessels: An Immunohistochemical Demonstration of L-Glutamic Acid Decarboxylase and GABA Transaminase" @default.
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• W2085236872 doi "https://doi.org/10.1038/jcbfm.1991.15" @default.
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