FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085241467> ?p ?o ?g. }

• W2085241467 endingPage "1083" @default.
• W2085241467 startingPage "1080" @default.
• W2085241467 abstract "Werner syndrome (WS), caused by mutations in a gene (WRN) that encodes a RecQ DNA helicase, is characterized by premature aging and cancer predisposition. Cells derived from WS patients show sensitivity to several DNA damaging agents. Previous studies revealed that the WRN protein plays roles in DNA repair or damage tolerance, although it was not yet assigned to a specific pathway. Here we examined the relationship between WRN and the post-replication repair protein RAD18 by generating deletion derivatives in chicken DT40 cells. The frequency of spontaneous sister chromatid exchange in WRN(-/-)/RAD18(-/-) double mutant cells was slightly increased compared to that of either single mutant. However, the sensitivity of WRN(-/-)/RAD18(-/-) cells to 4-nitroquinoline 1-oxide and methyl methanesulfonate was almost the same as that of RAD18(-/-) cells. Moreover, the cisplatin sensitivity of RAD18(-/-) cells was slightly suppressed by disruption of WRN. These data suggest that WRN functions in a pathway involving RAD18 under damage-inducing conditions." @default.
• W2085241467 created "2016-06-24" @default.
• W2085241467 creator A5018115010 @default.
• W2085241467 creator A5021808088 @default.
• W2085241467 creator A5026386730 @default.
• W2085241467 creator A5029228857 @default.
• W2085241467 creator A5043795759 @default.
• W2085241467 creator A5060969637 @default.
• W2085241467 creator A5062915484 @default.
• W2085241467 date "2007-01-01" @default.
• W2085241467 modified "2023-10-18" @default.
• W2085241467 title "WRN Functions in a RAD18-Dependent Damage Avoidance Pathway" @default.
• W2085241467 cites W1538603370 @default.
• W2085241467 cites W1549591813 @default.
• W2085241467 cites W1940074648 @default.
• W2085241467 cites W1964143371 @default.
• W2085241467 cites W1980890214 @default.
• W2085241467 cites W1986519836 @default.
• W2085241467 cites W1998617902 @default.
• W2085241467 cites W2008669260 @default.
• W2085241467 cites W2010655896 @default.
• W2085241467 cites W2028408120 @default.
• W2085241467 cites W2031670770 @default.
• W2085241467 cites W2054918042 @default.
• W2085241467 cites W2056430311 @default.
• W2085241467 cites W2064310741 @default.
• W2085241467 cites W2066253067 @default.
• W2085241467 cites W2069385762 @default.
• W2085241467 cites W2071924188 @default.
• W2085241467 cites W2084712319 @default.
• W2085241467 cites W2088614788 @default.
• W2085241467 cites W2094556673 @default.
• W2085241467 cites W2099649920 @default.
• W2085241467 cites W2116217779 @default.
• W2085241467 cites W2119301405 @default.
• W2085241467 cites W2119940546 @default.
• W2085241467 cites W2123292607 @default.
• W2085241467 cites W2130306939 @default.
• W2085241467 cites W2131424666 @default.
• W2085241467 cites W2133425142 @default.
• W2085241467 cites W2153043528 @default.
• W2085241467 cites W2330395802 @default.
• W2085241467 doi "https://doi.org/10.1248/bpb.30.1080" @default.
• W2085241467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17541157" @default.
• W2085241467 hasPublicationYear "2007" @default.
• W2085241467 type Work @default.
• W2085241467 sameAs 2085241467 @default.
• W2085241467 citedByCount "10" @default.
• W2085241467 countsByYear W20852414672012 @default.
• W2085241467 countsByYear W20852414672018 @default.
• W2085241467 crossrefType "journal-article" @default.
• W2085241467 hasAuthorship W2085241467A5018115010 @default.
• W2085241467 hasAuthorship W2085241467A5021808088 @default.
• W2085241467 hasAuthorship W2085241467A5026386730 @default.
• W2085241467 hasAuthorship W2085241467A5029228857 @default.
• W2085241467 hasAuthorship W2085241467A5043795759 @default.
• W2085241467 hasAuthorship W2085241467A5060969637 @default.
• W2085241467 hasAuthorship W2085241467A5062915484 @default.
• W2085241467 hasBestOaLocation W20852414671 @default.
• W2085241467 hasConcept C104317684 @default.
• W2085241467 hasConcept C134935766 @default.
• W2085241467 hasConcept C143065580 @default.
• W2085241467 hasConcept C143425029 @default.
• W2085241467 hasConcept C153911025 @default.
• W2085241467 hasConcept C161223559 @default.
• W2085241467 hasConcept C16318435 @default.
• W2085241467 hasConcept C178169997 @default.
• W2085241467 hasConcept C2776900477 @default.
• W2085241467 hasConcept C2778090637 @default.
• W2085241467 hasConcept C2779071816 @default.
• W2085241467 hasConcept C2780751114 @default.
• W2085241467 hasConcept C501734568 @default.
• W2085241467 hasConcept C54355233 @default.
• W2085241467 hasConcept C552990157 @default.
• W2085241467 hasConcept C67705224 @default.
• W2085241467 hasConcept C73573662 @default.
• W2085241467 hasConcept C86803240 @default.
• W2085241467 hasConcept C95444343 @default.
• W2085241467 hasConceptScore W2085241467C104317684 @default.
• W2085241467 hasConceptScore W2085241467C134935766 @default.
• W2085241467 hasConceptScore W2085241467C143065580 @default.
• W2085241467 hasConceptScore W2085241467C143425029 @default.
• W2085241467 hasConceptScore W2085241467C153911025 @default.
• W2085241467 hasConceptScore W2085241467C161223559 @default.
• W2085241467 hasConceptScore W2085241467C16318435 @default.
• W2085241467 hasConceptScore W2085241467C178169997 @default.
• W2085241467 hasConceptScore W2085241467C2776900477 @default.
• W2085241467 hasConceptScore W2085241467C2778090637 @default.
• W2085241467 hasConceptScore W2085241467C2779071816 @default.
• W2085241467 hasConceptScore W2085241467C2780751114 @default.
• W2085241467 hasConceptScore W2085241467C501734568 @default.
• W2085241467 hasConceptScore W2085241467C54355233 @default.
• W2085241467 hasConceptScore W2085241467C552990157 @default.
• W2085241467 hasConceptScore W2085241467C67705224 @default.
• W2085241467 hasConceptScore W2085241467C73573662 @default.
• W2085241467 hasConceptScore W2085241467C86803240 @default.
• W2085241467 hasConceptScore W2085241467C95444343 @default.
• W2085241467 hasIssue "6" @default.

• next