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- W2085247949 endingPage "e979699" @default.
- W2085247949 startingPage "e979699" @default.
- W2085247949 abstract "Infantile hemangioma is a common tumor of infancy. Although most hemangiomas spontaneously regress, treatment is indicated based on complications, risk to organ development and function, and disfigurement. The serendipitous discovery of propranolol, a non-selective β-adrenergic receptor blocker, as an effective means to regress hemangiomas has made this a first-line therapy for hemangioma patients. Propranolol has shown remarkable response rates. There are, however, some adverse effects, which include changes in sleep, acrocyanosis, hypotension, and hypoglycemia. Over the last few years, researchers have focused on understanding the mechanisms by which propranolol causes hemangioma regression. This has entailed study of cultured vascular endothelial cells including endothelial cells isolated from hemangioma patients. In this article, we review recent studies offering potential mechanisms of how various cell types found in hemangioma may respond to propranolol." @default.
- W2085247949 created "2016-06-24" @default.
- W2085247949 creator A5011169519 @default.
- W2085247949 creator A5026817489 @default.
- W2085247949 date "2014-01-01" @default.
- W2085247949 modified "2023-09-24" @default.
- W2085247949 title "Mechanisms of propranolol action in infantile hemangioma" @default.
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