FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085249940> ?p ?o ?g. }

• W2085249940 endingPage "898" @default.
• W2085249940 startingPage "892" @default.
• W2085249940 abstract "p53 is a key modulator of a variety of cellular stresses. In human neuroblastomas, p53 is rarely mutated and aberrantly expressed in cytoplasm. In this study, we have identified a novel p53 mutant lacking its COOH-terminal region in neuroblastoma SK-N-AS cells. p53 accumulated in response to cisplatin (CDDP) and thereby promoting apoptosis in neuroblastoma SH-SY5Y cells bearing wild-type p53, whereas SK-N-AS cells did not undergo apoptosis. We found another p53 (p53DeltaC) lacking a part of oligomerization domain and nuclear localization signals in SK-N-AS cells. p53DeltaC was expressed largely in cytoplasm and lost the transactivation function. Furthermore, a 3'-part of the p53 locus was homozygously deleted in SK-N-AS cells. Thus, our present findings suggest that p53 plays an important role in the DNA-damage response in certain neuroblastoma cells and it seems to be important to search for p53 mutations outside DNA-binding domain." @default.
• W2085249940 created "2016-06-24" @default.
• W2085249940 creator A5024295857 @default.
• W2085249940 creator A5029429842 @default.
• W2085249940 creator A5030104503 @default.
• W2085249940 creator A5034252509 @default.
• W2085249940 creator A5059436010 @default.
• W2085249940 creator A5064427269 @default.
• W2085249940 date "2007-03-01" @default.
• W2085249940 modified "2023-09-23" @default.
• W2085249940 title "Functional characterization of a new p53 mutant generated by homozygous deletion in a neuroblastoma cell line" @default.
• W2085249940 cites W100225602 @default.
• W2085249940 cites W1481143593 @default.
• W2085249940 cites W1746080159 @default.
• W2085249940 cites W1965363596 @default.
• W2085249940 cites W1969261030 @default.
• W2085249940 cites W1985064409 @default.
• W2085249940 cites W1987957628 @default.
• W2085249940 cites W2042316019 @default.
• W2085249940 cites W2056530510 @default.
• W2085249940 cites W2060584880 @default.
• W2085249940 cites W2063669247 @default.
• W2085249940 cites W2082979850 @default.
• W2085249940 cites W2085523227 @default.
• W2085249940 cites W2095402954 @default.
• W2085249940 cites W2097565501 @default.
• W2085249940 cites W2105933029 @default.
• W2085249940 cites W2126679757 @default.
• W2085249940 cites W2148894332 @default.
• W2085249940 cites W2150097377 @default.
• W2085249940 cites W2153349744 @default.
• W2085249940 cites W2155570392 @default.
• W2085249940 doi "https://doi.org/10.1016/j.bbrc.2007.01.057" @default.
• W2085249940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17276397" @default.
• W2085249940 hasPublicationYear "2007" @default.
• W2085249940 type Work @default.
• W2085249940 sameAs 2085249940 @default.
• W2085249940 citedByCount "32" @default.
• W2085249940 countsByYear W20852499402012 @default.
• W2085249940 countsByYear W20852499402013 @default.
• W2085249940 countsByYear W20852499402014 @default.
• W2085249940 countsByYear W20852499402015 @default.
• W2085249940 countsByYear W20852499402016 @default.
• W2085249940 countsByYear W20852499402017 @default.
• W2085249940 countsByYear W20852499402018 @default.
• W2085249940 countsByYear W20852499402020 @default.
• W2085249940 countsByYear W20852499402021 @default.
• W2085249940 countsByYear W20852499402022 @default.
• W2085249940 crossrefType "journal-article" @default.
• W2085249940 hasAuthorship W2085249940A5024295857 @default.
• W2085249940 hasAuthorship W2085249940A5029429842 @default.
• W2085249940 hasAuthorship W2085249940A5030104503 @default.
• W2085249940 hasAuthorship W2085249940A5034252509 @default.
• W2085249940 hasAuthorship W2085249940A5059436010 @default.
• W2085249940 hasAuthorship W2085249940A5064427269 @default.
• W2085249940 hasConcept C104317684 @default.
• W2085249940 hasConcept C1292079 @default.
• W2085249940 hasConcept C143065580 @default.
• W2085249940 hasConcept C143425029 @default.
• W2085249940 hasConcept C153911025 @default.
• W2085249940 hasConcept C190062978 @default.
• W2085249940 hasConcept C190283241 @default.
• W2085249940 hasConcept C2776715637 @default.
• W2085249940 hasConcept C502942594 @default.
• W2085249940 hasConcept C54355233 @default.
• W2085249940 hasConcept C552990157 @default.
• W2085249940 hasConcept C81885089 @default.
• W2085249940 hasConcept C84597430 @default.
• W2085249940 hasConcept C86339819 @default.
• W2085249940 hasConcept C86803240 @default.
• W2085249940 hasConcept C95444343 @default.
• W2085249940 hasConceptScore W2085249940C104317684 @default.
• W2085249940 hasConceptScore W2085249940C1292079 @default.
• W2085249940 hasConceptScore W2085249940C143065580 @default.
• W2085249940 hasConceptScore W2085249940C143425029 @default.
• W2085249940 hasConceptScore W2085249940C153911025 @default.
• W2085249940 hasConceptScore W2085249940C190062978 @default.
• W2085249940 hasConceptScore W2085249940C190283241 @default.
• W2085249940 hasConceptScore W2085249940C2776715637 @default.
• W2085249940 hasConceptScore W2085249940C502942594 @default.
• W2085249940 hasConceptScore W2085249940C54355233 @default.
• W2085249940 hasConceptScore W2085249940C552990157 @default.
• W2085249940 hasConceptScore W2085249940C81885089 @default.
• W2085249940 hasConceptScore W2085249940C84597430 @default.
• W2085249940 hasConceptScore W2085249940C86339819 @default.
• W2085249940 hasConceptScore W2085249940C86803240 @default.
• W2085249940 hasConceptScore W2085249940C95444343 @default.
• W2085249940 hasFunder F4320310760 @default.
• W2085249940 hasFunder F4320320912 @default.
• W2085249940 hasFunder F4320321945 @default.
• W2085249940 hasFunder F4320334764 @default.
• W2085249940 hasIssue "4" @default.
• W2085249940 hasLocation W20852499401 @default.
• W2085249940 hasLocation W20852499402 @default.
• W2085249940 hasOpenAccess W2085249940 @default.
• W2085249940 hasPrimaryLocation W20852499401 @default.
• W2085249940 hasRelatedWork W1234816868 @default.
• W2085249940 hasRelatedWork W1543358981 @default.

• next