Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085251552> ?p ?o ?g. }
- W2085251552 endingPage "1358" @default.
- W2085251552 startingPage "1349" @default.
- W2085251552 abstract "P311, also called PTZ17, was identified by suppressive subtraction hybridization as potentially involved in smooth muscle (SM) myogenesis. P311 is an 8-kDa protein with several PEST-like motifs found in neurons and muscle. P311 transfection into two fibroblast cell lines, NIH 3T3 and C3H10 T1/2, induced phenotypic changes consistent with myofibroblast transformation, including upregulation of SM alpha-actin and SM22, induction of FGF-2, VEGF, PDGF, and PDGF receptors, upregulation of integrins alpha3 and alpha5, and increased proliferation rate. The P311-mediated changes differed, however, from the well-characterized myofibroblast in that P311 inhibited TGF-beta1, TGF-beta receptor 2, and TGF-beta1-activating MMP-2 and MMP-9, with the resultant decrease in collagen 1 and 3 expression. The effect of P311 on collagen was overcome by exogenous TGF-beta1, indicating that the cells were responsive to TGF-beta1 paracrine stimulus. In support of a role for P311 in vivo, immunohistochemical examination of human wounds showed P311 only in myofibroblasts and their activated precursors. To our knowledge, these studies are the first to implicate P311 in myofibroblast transformation, to demonstrate that transformation may occur independently of TGF-beta1, and to suggest that P311 may prevent fibrosis." @default.
- W2085251552 created "2016-06-24" @default.
- W2085251552 creator A5033645607 @default.
- W2085251552 creator A5062871652 @default.
- W2085251552 creator A5079606398 @default.
- W2085251552 creator A5085700259 @default.
- W2085251552 creator A5085775894 @default.
- W2085251552 date "2002-11-01" @default.
- W2085251552 modified "2023-10-17" @default.
- W2085251552 title "P311 induces a TGF-β1–independent, nonfibrogenic myofibroblast phenotype" @default.
- W2085251552 cites W1533133582 @default.
- W2085251552 cites W1534692597 @default.
- W2085251552 cites W1594157448 @default.
- W2085251552 cites W1810880126 @default.
- W2085251552 cites W1849488471 @default.
- W2085251552 cites W1932132006 @default.
- W2085251552 cites W1963548830 @default.
- W2085251552 cites W1973418567 @default.
- W2085251552 cites W1979282423 @default.
- W2085251552 cites W1980544596 @default.
- W2085251552 cites W1981916517 @default.
- W2085251552 cites W1981920590 @default.
- W2085251552 cites W1987719408 @default.
- W2085251552 cites W1988198028 @default.
- W2085251552 cites W1988850323 @default.
- W2085251552 cites W1989021197 @default.
- W2085251552 cites W1991075485 @default.
- W2085251552 cites W1991144688 @default.
- W2085251552 cites W1991863368 @default.
- W2085251552 cites W2001398345 @default.
- W2085251552 cites W2007310561 @default.
- W2085251552 cites W2016193552 @default.
- W2085251552 cites W2016685492 @default.
- W2085251552 cites W2025224640 @default.
- W2085251552 cites W2033425013 @default.
- W2085251552 cites W2042159165 @default.
- W2085251552 cites W2048142624 @default.
- W2085251552 cites W2049383144 @default.
- W2085251552 cites W2064764984 @default.
- W2085251552 cites W2070995184 @default.
- W2085251552 cites W2083398588 @default.
- W2085251552 cites W2092644867 @default.
- W2085251552 cites W2096280264 @default.
- W2085251552 cites W2100336306 @default.
- W2085251552 cites W2103031848 @default.
- W2085251552 cites W2120934175 @default.
- W2085251552 cites W2126466803 @default.
- W2085251552 cites W2132823963 @default.
- W2085251552 cites W2132958035 @default.
- W2085251552 cites W2133323445 @default.
- W2085251552 cites W2136566814 @default.
- W2085251552 cites W2138131495 @default.
- W2085251552 cites W2140700551 @default.
- W2085251552 cites W2146194861 @default.
- W2085251552 cites W2151209025 @default.
- W2085251552 cites W2165537590 @default.
- W2085251552 cites W2169234200 @default.
- W2085251552 cites W2171530502 @default.
- W2085251552 cites W2188064034 @default.
- W2085251552 cites W2335187016 @default.
- W2085251552 cites W2461169750 @default.
- W2085251552 cites W2935273799 @default.
- W2085251552 doi "https://doi.org/10.1172/jci15614" @default.
- W2085251552 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/151607" @default.
- W2085251552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12417574" @default.
- W2085251552 hasPublicationYear "2002" @default.
- W2085251552 type Work @default.
- W2085251552 sameAs 2085251552 @default.
- W2085251552 citedByCount "32" @default.
- W2085251552 countsByYear W20852515522012 @default.
- W2085251552 countsByYear W20852515522013 @default.
- W2085251552 countsByYear W20852515522015 @default.
- W2085251552 countsByYear W20852515522016 @default.
- W2085251552 countsByYear W20852515522017 @default.
- W2085251552 countsByYear W20852515522018 @default.
- W2085251552 countsByYear W20852515522019 @default.
- W2085251552 countsByYear W20852515522020 @default.
- W2085251552 countsByYear W20852515522021 @default.
- W2085251552 countsByYear W20852515522022 @default.
- W2085251552 countsByYear W20852515522023 @default.
- W2085251552 crossrefType "journal-article" @default.
- W2085251552 hasAuthorship W2085251552A5033645607 @default.
- W2085251552 hasAuthorship W2085251552A5062871652 @default.
- W2085251552 hasAuthorship W2085251552A5079606398 @default.
- W2085251552 hasAuthorship W2085251552A5085700259 @default.
- W2085251552 hasAuthorship W2085251552A5085775894 @default.
- W2085251552 hasBestOaLocation W20852515521 @default.
- W2085251552 hasConcept C104317684 @default.
- W2085251552 hasConcept C127561419 @default.
- W2085251552 hasConcept C142724271 @default.
- W2085251552 hasConcept C153911025 @default.
- W2085251552 hasConcept C170493617 @default.
- W2085251552 hasConcept C180361614 @default.
- W2085251552 hasConcept C207865475 @default.
- W2085251552 hasConcept C2775960820 @default.
- W2085251552 hasConcept C2780381497 @default.
- W2085251552 hasConcept C2780559512 @default.
- W2085251552 hasConcept C54009773 @default.