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- W2085254992 abstract "Pyridoxine is not completely innocuous. Large doses can cause a peripheral neuropathy despite renal excretion of this water-soluble vitamin. Renal failure patients are treated with pyridoxine to prevent a deficiency. The safety of pyridoxine treatment in the presence of renal dysfunction has not been studied. Our experiments on anephric rats show that the uremic state, in a mere 3 or 4 days, causes a 5- to 10-fold increase in susceptibility to pyridoxine-induced neuronopathy. These results suggest a need for caution in prescribing pyridoxine to uremic patients who will probably take the vitamin daily for many years." @default.
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- W2085254992 date "2002-10-01" @default.
- W2085254992 modified "2023-09-27" @default.
- W2085254992 title "Pyridoxine (vitamin B6) toxicity: enhancement by uremia in rats" @default.
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- W2085254992 doi "https://doi.org/10.1016/s0278-6915(02)00072-8" @default.
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