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- W2085257106 abstract "Central venous catheters are reluctantly used as blood access for hemodialysis because of safety concerns and frequent complications, e.g., sepsis, thrombosis and vessel stenosis. Nevertheless, 20% or more of all patients are relying on atrial catheters for chronic dialysis because of lack of any other blood access. Two recent developments tackle the most critical problems of the catheter: safety and sepsis. An implantable access port ameliorates or eliminates safety problems as air embolism and blood loss to the environment and the antimicrobial locking solution eliminates sepsis related to biofilms in catheters. This paper reports about results of a German Dialock®/CLS study, the first study using an antimicrobial catheter locking solution in a large number of patients. Dialock and CLS have been developed by Biolink Corp., USA. The study was approved in May 1998 by the ethics committee of the ‘Landesarztekammer Baden-Wurttemberg’. Eligible patients were at least 18 years of age requiring hemodialysis. Inclusion criteria were vessel exhaustion and/or congestive heart failure. Pregnancy and inability to provide informed consent were exclusion criteria. The purpose of this pilot trial was to demonstrate the safety and efficacy of the Dialock in combination with a new heparin-free antimicrobial lock solution. Materials" @default.
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- W2085257106 date "2000-12-28" @default.
- W2085257106 modified "2023-09-26" @default.
- W2085257106 title "Two Years’ Experience with Dialock<sup>®</sup> and CLS<sup>TM</sup> (A New Antimicrobial Lock Solution)" @default.
- W2085257106 cites W2007203175 @default.
- W2085257106 doi "https://doi.org/10.1159/000046950" @default.
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