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• W2085258660 abstract "To compare the organ injuries by cadmium administration among inbred strains of mice, CdCl2 was injected subcutaneously into C3H/He, BALB/c, DBA/2, CBA/J and C57BL/6 strains at a dose of 30 mumol/kg body weight, and the changes of 6 essential metal [sodium (Na), magnesium (Mg), potassium (K), calcium (Ca), iron (Fe) and zinc (Zn)] concentrations were determined at 6, 24 and 48 h. Testicular Cd concentrations at 6 h in DBA/2 and CBA/J were significantly higher than those in the other 3 strains. Marked alterations in testicular metal concentrations (increases in Na, Ca and Fe and decreases in K and Mg) were observed in the 2 strains. At 48 h, hepatic Cd concentration in BALB/c was decreased from the higher level at 24 h and an abrupt increase in renal Cd concentration was detected. Changes in hepatic essential metal concentrations at 48 h in BALB/c were in the same direction as those in the testis of DBA/2 and CBA/J. As a whole, C3H/He, BALB/c and C57BL/6 strains showed more remarkable alterations in hepatic essential metal concentrations, except Zn level, than DBA/2 and CBA/J which showed larger increases in Zn concentration (probably due to larger metallothionein induction). It was suggested from the data that C3H/He, BALB/c and C57BL/6 were strains sensitive to the hepatotoxicity of Cd and that DBA/2 and CBA/J were susceptible to the testicular toxicity of Cd." @default.
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• W2085258660 date "1986-12-15" @default.
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• W2085258660 title "Effect of cadmium on essential metal concentrations in testis, liver and kidney of five inbred strains of mice" @default.
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• W2085258660 doi "https://doi.org/10.1016/0300-483x(86)90003-x" @default.
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