Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085261351> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2085261351 endingPage "51" @default.
- W2085261351 startingPage "41" @default.
- W2085261351 abstract "Cholecystokinin (CCK) is a hormonal regulator of the motility of the gallbladder. CCK-8, i.e. the biologically active C-terminal octapeptide of the hormone, elicits contraction and emptying of the gallbladder. Endogenous CCK released by egg yolk or fatty acids in the duodenum gives the same results. CR 1409 (lorglumide), a glutaramic acid derivative with peripheric competitive CCK-antagonistic activity, was evaluated in comparison with proglumide (the model CCK-receptor antagonist) and other conventional antispasmodic drugs, for their ability to inhibit the emptying of the gallbladder induced in mice by CCK-8 or by lyophylized egg yolk. CR 1409 (1-10 mg/kg) prevented dose-dependently the emptying of the gallbladder in both experimental models; proglumide exhibited a comparable activity at much higher doses (200-800 mg/kg). On the contrary the anticholinergic drug atropine, the calcium-antagonist nifedipine, and the phosphodiesterase inhibitor papaverine were almost ineffective. The present data support the hypothesis that the effects of CCK on gallbladder motility are mediated by a CCK-dependent specific mechanism." @default.
- W2085261351 created "2016-06-24" @default.
- W2085261351 creator A5015297445 @default.
- W2085261351 creator A5028763418 @default.
- W2085261351 creator A5035150423 @default.
- W2085261351 creator A5042766116 @default.
- W2085261351 creator A5055289155 @default.
- W2085261351 creator A5066549404 @default.
- W2085261351 creator A5082438258 @default.
- W2085261351 date "1987-01-01" @default.
- W2085261351 modified "2023-09-27" @default.
- W2085261351 title "Antispasdomic activity on the gallbladder of the mouse of CR 1409 (Lorglumide) a potent antagonist of peripheral CCK" @default.
- W2085261351 cites W10230571 @default.
- W2085261351 cites W1682371140 @default.
- W2085261351 cites W1999356137 @default.
- W2085261351 cites W2326832967 @default.
- W2085261351 cites W2396515997 @default.
- W2085261351 cites W2411372245 @default.
- W2085261351 cites W2579688957 @default.
- W2085261351 doi "https://doi.org/10.1016/0031-6989(87)90031-2" @default.
- W2085261351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3575382" @default.
- W2085261351 hasPublicationYear "1987" @default.
- W2085261351 type Work @default.
- W2085261351 sameAs 2085261351 @default.
- W2085261351 citedByCount "20" @default.
- W2085261351 countsByYear W20852613512012 @default.
- W2085261351 crossrefType "journal-article" @default.
- W2085261351 hasAuthorship W2085261351A5015297445 @default.
- W2085261351 hasAuthorship W2085261351A5028763418 @default.
- W2085261351 hasAuthorship W2085261351A5035150423 @default.
- W2085261351 hasAuthorship W2085261351A5042766116 @default.
- W2085261351 hasAuthorship W2085261351A5055289155 @default.
- W2085261351 hasAuthorship W2085261351A5066549404 @default.
- W2085261351 hasAuthorship W2085261351A5082438258 @default.
- W2085261351 hasConcept C126322002 @default.
- W2085261351 hasConcept C134018914 @default.
- W2085261351 hasConcept C170493617 @default.
- W2085261351 hasConcept C185592680 @default.
- W2085261351 hasConcept C2776079162 @default.
- W2085261351 hasConcept C2776885963 @default.
- W2085261351 hasConcept C2777148285 @default.
- W2085261351 hasConcept C2777593968 @default.
- W2085261351 hasConcept C32110497 @default.
- W2085261351 hasConcept C71924100 @default.
- W2085261351 hasConcept C98274493 @default.
- W2085261351 hasConceptScore W2085261351C126322002 @default.
- W2085261351 hasConceptScore W2085261351C134018914 @default.
- W2085261351 hasConceptScore W2085261351C170493617 @default.
- W2085261351 hasConceptScore W2085261351C185592680 @default.
- W2085261351 hasConceptScore W2085261351C2776079162 @default.
- W2085261351 hasConceptScore W2085261351C2776885963 @default.
- W2085261351 hasConceptScore W2085261351C2777148285 @default.
- W2085261351 hasConceptScore W2085261351C2777593968 @default.
- W2085261351 hasConceptScore W2085261351C32110497 @default.
- W2085261351 hasConceptScore W2085261351C71924100 @default.
- W2085261351 hasConceptScore W2085261351C98274493 @default.
- W2085261351 hasIssue "1" @default.
- W2085261351 hasLocation W20852613511 @default.
- W2085261351 hasLocation W20852613512 @default.
- W2085261351 hasOpenAccess W2085261351 @default.
- W2085261351 hasPrimaryLocation W20852613511 @default.
- W2085261351 hasRelatedWork W1982594208 @default.
- W2085261351 hasRelatedWork W1990600601 @default.
- W2085261351 hasRelatedWork W1993973335 @default.
- W2085261351 hasRelatedWork W2003764714 @default.
- W2085261351 hasRelatedWork W2019482019 @default.
- W2085261351 hasRelatedWork W2027797486 @default.
- W2085261351 hasRelatedWork W2031272904 @default.
- W2085261351 hasRelatedWork W2098042755 @default.
- W2085261351 hasRelatedWork W2409513954 @default.
- W2085261351 hasRelatedWork W253986189 @default.
- W2085261351 hasVolume "19" @default.
- W2085261351 isParatext "false" @default.
- W2085261351 isRetracted "false" @default.
- W2085261351 magId "2085261351" @default.
- W2085261351 workType "article" @default.