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• W2085263189 endingPage "145104" @default.
• W2085263189 startingPage "145104" @default.
• W2085263189 abstract "The effect of seeds in templating the morphology of peptide aggregates is examined using molecular dynamics simulations and a coarse-grained peptide representation. Varying the nature of the aggregate seed between β-sheet, amorphous, and β-barrel seeds leads to different aggregation pathways and to morphologically different aggregates. Similar effects are seen by varying the β-sheet propensity of the free peptides. For a fibrillar seed and free peptides of high β-sheet propensity, fibrillar growth occurred by means of direct attachment (without structural rearrangement) of free individual peptides and small ordered oligomers onto the seed. For a fibrillar seed and free peptides of low β-sheet propensity, fibrillar growth occurred through a dock-lock mechanism, in which the free peptides first docked onto the seed, and then locked on, extending and aligning to join the fibril. Amorphous seeds absorbed free peptides into themselves indiscriminately, with any fibrillar rearrangement subsequent to this absorption by means of a condensation-ordering transition. Although the mechanisms observed by varying peptide β-sheet propensity are diverse, the initial pathways can always be broken down into the following steps: (i) the free peptides diffuse in the bulk and attach individually to the seed; (ii) the free peptides diffuse and aggregate among themselves; (iii) the free peptide oligomers collide with the seed; and (iv) the free oligomers merge with the seed and rearrange in a manner dependent on the backbone flexibility of both the free and seed peptides. Our simulations indicate that it is possible to sequester peptides from amorphous aggregates into fibrils, and also that aggregate morphology (and thus cytoxicity) can be controlled by introducing seeds of aggregate-compatible peptides with differing β-sheet propensities into the system." @default.
• W2085263189 created "2016-06-24" @default.
• W2085263189 creator A5014689969 @default.
• W2085263189 creator A5034059433 @default.
• W2085263189 creator A5034511172 @default.
• W2085263189 date "2012-10-14" @default.
• W2085263189 modified "2023-10-18" @default.
• W2085263189 title "β-sheet propensity controls the kinetic pathways and morphologies of seeded peptide aggregation" @default.
• W2085263189 cites W1534580850 @default.
• W2085263189 cites W1675055193 @default.
• W2085263189 cites W1964976698 @default.
• W2085263189 cites W1966694507 @default.
• W2085263189 cites W1967153514 @default.
• W2085263189 cites W1969296884 @default.
• W2085263189 cites W1971222918 @default.
• W2085263189 cites W1972567838 @default.
• W2085263189 cites W1976201852 @default.
• W2085263189 cites W1980482609 @default.
• W2085263189 cites W1987686455 @default.
• W2085263189 cites W1988146745 @default.
• W2085263189 cites W1990592765 @default.
• W2085263189 cites W1999017783 @default.
• W2085263189 cites W2004098528 @default.
• W2085263189 cites W2005426900 @default.
• W2085263189 cites W2006225923 @default.
• W2085263189 cites W2006516517 @default.
• W2085263189 cites W2007017976 @default.
• W2085263189 cites W2009604591 @default.
• W2085263189 cites W2010511290 @default.
• W2085263189 cites W2014882369 @default.
• W2085263189 cites W2016819659 @default.
• W2085263189 cites W2021785060 @default.
• W2085263189 cites W2022436525 @default.
• W2085263189 cites W2023285934 @default.
• W2085263189 cites W2024213084 @default.
• W2085263189 cites W2025399871 @default.
• W2085263189 cites W2025595434 @default.
• W2085263189 cites W2026247913 @default.
• W2085263189 cites W2037887546 @default.
• W2085263189 cites W2042413457 @default.
• W2085263189 cites W2043642345 @default.
• W2085263189 cites W2046093999 @default.
• W2085263189 cites W2049287820 @default.
• W2085263189 cites W2050207511 @default.
• W2085263189 cites W2052544304 @default.
• W2085263189 cites W2053645656 @default.
• W2085263189 cites W2057012035 @default.
• W2085263189 cites W2057709942 @default.
• W2085263189 cites W2060449809 @default.
• W2085263189 cites W2063679630 @default.
• W2085263189 cites W2066185874 @default.
• W2085263189 cites W2067066779 @default.
• W2085263189 cites W2068513553 @default.
• W2085263189 cites W2069531937 @default.
• W2085263189 cites W2070248552 @default.
• W2085263189 cites W2071953900 @default.
• W2085263189 cites W2072327749 @default.
• W2085263189 cites W2073394015 @default.
• W2085263189 cites W2074255526 @default.
• W2085263189 cites W2075068625 @default.
• W2085263189 cites W2076468390 @default.
• W2085263189 cites W2084970298 @default.
• W2085263189 cites W2088661320 @default.
• W2085263189 cites W2089836617 @default.
• W2085263189 cites W2091370335 @default.
• W2085263189 cites W2091913778 @default.
• W2085263189 cites W2094675822 @default.
• W2085263189 cites W2096601751 @default.
• W2085263189 cites W2097632069 @default.
• W2085263189 cites W2099092270 @default.
• W2085263189 cites W2099370040 @default.
• W2085263189 cites W2099653907 @default.
• W2085263189 cites W2104849621 @default.
• W2085263189 cites W2107947409 @default.
• W2085263189 cites W2110114053 @default.
• W2085263189 cites W2110793726 @default.
• W2085263189 cites W2117118343 @default.
• W2085263189 cites W2117446062 @default.
• W2085263189 cites W2121852375 @default.
• W2085263189 cites W2123998092 @default.
• W2085263189 cites W2125172857 @default.
• W2085263189 cites W2127265740 @default.
• W2085263189 cites W2136686218 @default.
• W2085263189 cites W2143264329 @default.
• W2085263189 cites W2150464190 @default.
• W2085263189 cites W2150999725 @default.
• W2085263189 cites W2155073864 @default.
• W2085263189 cites W2160664224 @default.
• W2085263189 cites W2161004584 @default.
• W2085263189 cites W2162741488 @default.
• W2085263189 cites W2165186407 @default.
• W2085263189 cites W2165227163 @default.
• W2085263189 cites W2167257433 @default.
• W2085263189 cites W2170519960 @default.
• W2085263189 cites W2331697743 @default.
• W2085263189 cites W3102930513 @default.
• W2085263189 doi "https://doi.org/10.1063/1.4755748" @default.
• W2085263189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23061868" @default.

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