Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085264133> ?p ?o ?g. }
- W2085264133 endingPage "e0126107" @default.
- W2085264133 startingPage "e0126107" @default.
- W2085264133 abstract "Mechanical properties of cells have been recognized as a biomarker for cellular cytoskeletal organization. As chemical treatments lead to cell cytoskeletal rearrangements, thereby, modifications of cellular mechanical properties, investigating cellular mechanical property variations provides insightful knowledge to effects of chemical treatments on cancer cells. In this study, the effects of eight different anticancer drugs on the mechanical properties of human prostate cancer cell (PC-3) are investigated using a recently developed control-based nanoindentation measurement (CNM) protocol on atomic force microscope (AFM). The CNM protocol overcomes the limits of other existing methods to in-liquid nanoindentation measurement of live cells on AFM, particularly for measuring mechanical properties of live cells. The Young's modulus of PC-3 cells treated by the eight drugs was measured by varying force loading rates over three orders of magnitude, and compared to the values of the control. The results showed that the Young's modulus of the PC-3 cells increased substantially by the eight drugs tested, and became much more pronounced as the force load rate increased. Moreover, two distinct trends were clearly expressed, where under the treatment of Disulfiram, paclitaxel, and MK-2206, the exponent coefficient of the frequency- modulus function remained almost unchanged, while with Celebrex, BAY, Totamine, TPA, and Vaproic acid, the exponential rate was significantly increased." @default.
- W2085264133 created "2016-06-24" @default.
- W2085264133 creator A5001937247 @default.
- W2085264133 creator A5012470707 @default.
- W2085264133 creator A5022457658 @default.
- W2085264133 creator A5029751161 @default.
- W2085264133 creator A5030475937 @default.
- W2085264133 date "2015-05-01" @default.
- W2085264133 modified "2023-10-11" @default.
- W2085264133 title "An Atomic Force Microscope Study Revealed Two Mechanisms in the Effect of Anticancer Drugs on Rate-Dependent Young’s Modulus of Human Prostate Cancer Cells" @default.
- W2085264133 cites W1966237854 @default.
- W2085264133 cites W1971030181 @default.
- W2085264133 cites W1992899755 @default.
- W2085264133 cites W1994109845 @default.
- W2085264133 cites W2000715732 @default.
- W2085264133 cites W2006073003 @default.
- W2085264133 cites W2008207415 @default.
- W2085264133 cites W2009778029 @default.
- W2085264133 cites W2020118391 @default.
- W2085264133 cites W2028017296 @default.
- W2085264133 cites W2030463167 @default.
- W2085264133 cites W2030642623 @default.
- W2085264133 cites W2031422672 @default.
- W2085264133 cites W2036180531 @default.
- W2085264133 cites W2051480289 @default.
- W2085264133 cites W2056731255 @default.
- W2085264133 cites W2061460308 @default.
- W2085264133 cites W2063376261 @default.
- W2085264133 cites W2067191 @default.
- W2085264133 cites W2070399579 @default.
- W2085264133 cites W2074536442 @default.
- W2085264133 cites W2078002094 @default.
- W2085264133 cites W2079253011 @default.
- W2085264133 cites W2080667928 @default.
- W2085264133 cites W2081892717 @default.
- W2085264133 cites W2083453016 @default.
- W2085264133 cites W2092994838 @default.
- W2085264133 cites W2095402756 @default.
- W2085264133 cites W2100041293 @default.
- W2085264133 cites W2101718054 @default.
- W2085264133 cites W2103988494 @default.
- W2085264133 cites W2114633339 @default.
- W2085264133 cites W2122615852 @default.
- W2085264133 cites W2124588770 @default.
- W2085264133 cites W2127096332 @default.
- W2085264133 cites W2147599162 @default.
- W2085264133 cites W2148104091 @default.
- W2085264133 cites W2150903279 @default.
- W2085264133 cites W2159750196 @default.
- W2085264133 cites W2166919244 @default.
- W2085264133 cites W2436152459 @default.
- W2085264133 cites W4301005853 @default.
- W2085264133 cites W2088227656 @default.
- W2085264133 doi "https://doi.org/10.1371/journal.pone.0126107" @default.
- W2085264133 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4416805" @default.
- W2085264133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25932632" @default.
- W2085264133 hasPublicationYear "2015" @default.
- W2085264133 type Work @default.
- W2085264133 sameAs 2085264133 @default.
- W2085264133 citedByCount "41" @default.
- W2085264133 countsByYear W20852641332016 @default.
- W2085264133 countsByYear W20852641332017 @default.
- W2085264133 countsByYear W20852641332018 @default.
- W2085264133 countsByYear W20852641332019 @default.
- W2085264133 countsByYear W20852641332020 @default.
- W2085264133 countsByYear W20852641332021 @default.
- W2085264133 countsByYear W20852641332022 @default.
- W2085264133 countsByYear W20852641332023 @default.
- W2085264133 crossrefType "journal-article" @default.
- W2085264133 hasAuthorship W2085264133A5001937247 @default.
- W2085264133 hasAuthorship W2085264133A5012470707 @default.
- W2085264133 hasAuthorship W2085264133A5022457658 @default.
- W2085264133 hasAuthorship W2085264133A5029751161 @default.
- W2085264133 hasAuthorship W2085264133A5030475937 @default.
- W2085264133 hasBestOaLocation W20852641331 @default.
- W2085264133 hasConcept C102951782 @default.
- W2085264133 hasConcept C121608353 @default.
- W2085264133 hasConcept C12554922 @default.
- W2085264133 hasConcept C126322002 @default.
- W2085264133 hasConcept C142669718 @default.
- W2085264133 hasConcept C1491633281 @default.
- W2085264133 hasConcept C159985019 @default.
- W2085264133 hasConcept C171250308 @default.
- W2085264133 hasConcept C185592680 @default.
- W2085264133 hasConcept C192562407 @default.
- W2085264133 hasConcept C43486711 @default.
- W2085264133 hasConcept C49326732 @default.
- W2085264133 hasConcept C55493867 @default.
- W2085264133 hasConcept C71924100 @default.
- W2085264133 hasConcept C86803240 @default.
- W2085264133 hasConcept C96232424 @default.
- W2085264133 hasConceptScore W2085264133C102951782 @default.
- W2085264133 hasConceptScore W2085264133C121608353 @default.
- W2085264133 hasConceptScore W2085264133C12554922 @default.
- W2085264133 hasConceptScore W2085264133C126322002 @default.
- W2085264133 hasConceptScore W2085264133C142669718 @default.
- W2085264133 hasConceptScore W2085264133C1491633281 @default.
- W2085264133 hasConceptScore W2085264133C159985019 @default.