FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085265346> ?p ?o ?g. }

• W2085265346 endingPage "458" @default.
• W2085265346 startingPage "453" @default.
• W2085265346 abstract "N(G)-nitro-D-arginine (d-NNA) could convert into N(G)-nitro-L-arginine (l-NNA) in vivo, and kidney is the major target organ. In the chiral inversion process, a number of reactive oxygen species (ROS) were generated and NOS activity was inhibited, which may cause renal damage. Salvia miltiorrhiza (SM), a traditional Chinese drug, was used in the treatment of cardiovascular diseases and chronic renal failure. The aim of the present study was to investigate the kidney damage caused by D-NNA administration for 12 weeks and to evaluate the effects of treatment with SM on D-NNA-induced kidney damage. The rats, induced with D-NNA for period of 12 weeks, showed significant elevation of Blood Urea Nitrogen (BUN), Creatinine (Crea) and MDA levels, and significant decrease of SOD and GSH-Px activities, as compared with control group. In addition, the kidney of rats induced with D-NNA only showed remarkable histopathology, including severe mononuclear cell infiltration, mild tubular dilatation and congestion, and moderate interstitial desmoplasia. After 4 weeks SM treatment, the activity of SOD, GSH-Px and iNOS and the production of NO were significantly higher (P<0.05), and the levels of BUN, Crea and MDA were significantly lower than that of D-NNA only group (P<0.05). In addition, treatment with SM showed histopathological protection in tubular dilatation, congestion, mononuclear cell infiltration and interstitial desmoplasia. The present results indicate that the toxicity of D-NNA relates to its ability to generate oxidative stress and upregulate NOS activity in rat kidney. SM probably ameliorates D-NNA-induced nephrotoxicity in rats according to scavenging free radical and upregulating NOS activity." @default.
• W2085265346 created "2016-06-24" @default.
• W2085265346 creator A5003746751 @default.
• W2085265346 creator A5004244292 @default.
• W2085265346 creator A5005651745 @default.
• W2085265346 creator A5006707373 @default.
• W2085265346 creator A5011221713 @default.
• W2085265346 creator A5015046037 @default.
• W2085265346 creator A5040558103 @default.
• W2085265346 creator A5059058234 @default.
• W2085265346 creator A5085643062 @default.
• W2085265346 creator A5091443349 @default.
• W2085265346 date "2012-07-01" @default.
• W2085265346 modified "2023-09-28" @default.
• W2085265346 title "Protective effect of Salvia Miltiorrhizae injection on N(G)-nitro-d-arginine induced nitric oxide deficient and oxidative damage in rat kidney" @default.
• W2085265346 cites W1503403486 @default.
• W2085265346 cites W1509676400 @default.
• W2085265346 cites W1583096188 @default.
• W2085265346 cites W1775749144 @default.
• W2085265346 cites W1971679655 @default.
• W2085265346 cites W1973677547 @default.
• W2085265346 cites W1990863512 @default.
• W2085265346 cites W1996332624 @default.
• W2085265346 cites W1999647919 @default.
• W2085265346 cites W2005349276 @default.
• W2085265346 cites W2009264782 @default.
• W2085265346 cites W2011307569 @default.
• W2085265346 cites W2023714210 @default.
• W2085265346 cites W2027771925 @default.
• W2085265346 cites W2037124575 @default.
• W2085265346 cites W2043625574 @default.
• W2085265346 cites W2045958890 @default.
• W2085265346 cites W2052143287 @default.
• W2085265346 cites W2057092234 @default.
• W2085265346 cites W2060194897 @default.
• W2085265346 cites W2068933269 @default.
• W2085265346 cites W2101447446 @default.
• W2085265346 cites W2127229934 @default.
• W2085265346 cites W2143828987 @default.
• W2085265346 cites W2144529887 @default.
• W2085265346 cites W2156097243 @default.
• W2085265346 doi "https://doi.org/10.1016/j.etp.2010.10.013" @default.
• W2085265346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21112748" @default.
• W2085265346 hasPublicationYear "2012" @default.
• W2085265346 type Work @default.
• W2085265346 sameAs 2085265346 @default.
• W2085265346 citedByCount "29" @default.
• W2085265346 countsByYear W20852653462012 @default.
• W2085265346 countsByYear W20852653462013 @default.
• W2085265346 countsByYear W20852653462014 @default.
• W2085265346 countsByYear W20852653462015 @default.
• W2085265346 countsByYear W20852653462016 @default.
• W2085265346 countsByYear W20852653462017 @default.
• W2085265346 countsByYear W20852653462018 @default.
• W2085265346 countsByYear W20852653462019 @default.
• W2085265346 countsByYear W20852653462020 @default.
• W2085265346 countsByYear W20852653462022 @default.
• W2085265346 crossrefType "journal-article" @default.
• W2085265346 hasAuthorship W2085265346A5003746751 @default.
• W2085265346 hasAuthorship W2085265346A5004244292 @default.
• W2085265346 hasAuthorship W2085265346A5005651745 @default.
• W2085265346 hasAuthorship W2085265346A5006707373 @default.
• W2085265346 hasAuthorship W2085265346A5011221713 @default.
• W2085265346 hasAuthorship W2085265346A5015046037 @default.
• W2085265346 hasAuthorship W2085265346A5040558103 @default.
• W2085265346 hasAuthorship W2085265346A5059058234 @default.
• W2085265346 hasAuthorship W2085265346A5085643062 @default.
• W2085265346 hasAuthorship W2085265346A5091443349 @default.
• W2085265346 hasConcept C126189478 @default.
• W2085265346 hasConcept C126322002 @default.
• W2085265346 hasConcept C134018914 @default.
• W2085265346 hasConcept C142724271 @default.
• W2085265346 hasConcept C185592680 @default.
• W2085265346 hasConcept C188947578 @default.
• W2085265346 hasConcept C204787440 @default.
• W2085265346 hasConcept C2776151105 @default.
• W2085265346 hasConcept C2776332195 @default.
• W2085265346 hasConcept C2777387769 @default.
• W2085265346 hasConcept C2778176769 @default.
• W2085265346 hasConcept C2780091579 @default.
• W2085265346 hasConcept C2780306776 @default.
• W2085265346 hasConcept C519581460 @default.
• W2085265346 hasConcept C71924100 @default.
• W2085265346 hasConcept C84393581 @default.
• W2085265346 hasConcept C98274493 @default.
• W2085265346 hasConceptScore W2085265346C126189478 @default.
• W2085265346 hasConceptScore W2085265346C126322002 @default.
• W2085265346 hasConceptScore W2085265346C134018914 @default.
• W2085265346 hasConceptScore W2085265346C142724271 @default.
• W2085265346 hasConceptScore W2085265346C185592680 @default.
• W2085265346 hasConceptScore W2085265346C188947578 @default.
• W2085265346 hasConceptScore W2085265346C204787440 @default.
• W2085265346 hasConceptScore W2085265346C2776151105 @default.
• W2085265346 hasConceptScore W2085265346C2776332195 @default.
• W2085265346 hasConceptScore W2085265346C2777387769 @default.
• W2085265346 hasConceptScore W2085265346C2778176769 @default.
• W2085265346 hasConceptScore W2085265346C2780091579 @default.
• W2085265346 hasConceptScore W2085265346C2780306776 @default.

• next