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• W2085266650 abstract "Huntington's disease is caused by a polyglutamine expansion in the protein huntingtin. Several studies suggest that huntingtin and its associated protein HAP1 participate in intracellular trafficking and that polyglutamine expansion affects vesicular transport. A study now provides new evidence that HAP1 is also involved in the endocytosis of membrane receptors. These studies offer insight into the normal function of HAP1 and its involvement in Huntington's disease. Huntington's disease is caused by a polyglutamine expansion in the protein huntingtin. Several studies suggest that huntingtin and its associated protein HAP1 participate in intracellular trafficking and that polyglutamine expansion affects vesicular transport. A study now provides new evidence that HAP1 is also involved in the endocytosis of membrane receptors. These studies offer insight into the normal function of HAP1 and its involvement in Huntington's disease." @default.
• W2085266650 created "2016-06-24" @default.
• W2085266650 creator A5072263969 @default.
• W2085266650 date "2005-01-01" @default.
• W2085266650 modified "2023-10-09" @default.
• W2085266650 title "HAP1 and intracellular trafficking" @default.
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• W2085266650 doi "https://doi.org/10.1016/j.tips.2004.11.001" @default.
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