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- W2085268210 abstract "Toxic material, lethal to mice and rats, was extracted from the tentacles of Chironex fleckeri from which nematocysts had been previously removed. The tentacle toxin was inactivated by heating at 35° or by exposure to proteolytic enzymes. The hearts of rats injected with the toxin showed a decrease in amplitude of cardiac contractions, bradycardia and atrioventricular block. After a small initial rise the arterial blood pressure of injected rats showed a pronounced fall. Conduction in the sciatic nerve of rats or toads was blocked by the toxin. The toxin possessed hemolytic activity. The tentacle toxin elicited no direct activity on vertebrate or crustacean skeletal musculature and showed negligible dermonecrotic activity. In these and many other respects its pharmacological activity was markedly different from that exhibited by the toxin isolated from nematocysts" @default.
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- W2085268210 date "1971-07-01" @default.
- W2085268210 modified "2023-10-18" @default.
- W2085268210 title "Toxic material from the tentacles of the cubomedusan Chironex fleckeri" @default.
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- W2085268210 doi "https://doi.org/10.1016/0041-0101(71)90078-x" @default.
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