FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085269916> ?p ?o ?g. }

• W2085269916 endingPage "385" @default.
• W2085269916 startingPage "379" @default.
• W2085269916 abstract "Cavernous hemangioma is vascular malformation with developmental aberrations. It was assumed that the abnormality of endothelial cells contributed greatly to the occurrence of cavernous hemangioma. In our previous study, we have found distinct characteristics of endothelial cells derived from human liver cavernous hemangioma (HCHEC). Here, we reported the abnormal vascular vessels formed by primary HCHEC in nude mice and that the drug podophyllotoxin can destroy HCHEC in vitro and in vivo. HCHEC was isolated from a human liver cavernous hemangioma specimen, and the HCHEC generated a red hemangioma-like mass 7 days after subcutaneously co-inoculating HCHEC and human liver cancer cells (Bel-7402) in nude mice. Lentiviral expression of GFP and immunohistochemistry for human CD31 was used to confirm that the HCHEC formed the blood vessels in nude mice. And the pathological features of vascular vessels formed by HCHEC were very similar to clinical cavernous hemangioma. In addition, by MTT assay, the drug podophyllotoxin was found inhibiting HCHEC viability, and by TUNEL and DNA ladder assays, podophyllotoxin was found inducing apoptosis of HCHEC. Moreover, podophyllotoxin was also effective for destroying the abnormal vascular vessels in the hemangioma-like mass in nude mice. In summary, the HCHEC can form abnormal blood vessels in nude mice, and we can evaluate drugs for cavernous hemangioma by using HCHEC in vitro and in vivo." @default.
• W2085269916 created "2016-06-24" @default.
• W2085269916 creator A5006319533 @default.
• W2085269916 creator A5030941717 @default.
• W2085269916 creator A5043141098 @default.
• W2085269916 creator A5044867102 @default.
• W2085269916 creator A5051380367 @default.
• W2085269916 creator A5061954972 @default.
• W2085269916 creator A5077882891 @default.
• W2085269916 date "2009-12-01" @default.
• W2085269916 modified "2023-10-16" @default.
• W2085269916 title "Abnormal blood vessels formed by human liver cavernous hemangioma endothelial cells in nude mice are suitable for drug evaluation" @default.
• W2085269916 cites W1564936783 @default.
• W2085269916 cites W1970028203 @default.
• W2085269916 cites W1990002167 @default.
• W2085269916 cites W1995404379 @default.
• W2085269916 cites W1998238306 @default.
• W2085269916 cites W2005151288 @default.
• W2085269916 cites W2006628947 @default.
• W2085269916 cites W2006904593 @default.
• W2085269916 cites W2020602736 @default.
• W2085269916 cites W2050423350 @default.
• W2085269916 cites W2050888665 @default.
• W2085269916 cites W2057909542 @default.
• W2085269916 cites W2072603916 @default.
• W2085269916 cites W2074711999 @default.
• W2085269916 cites W2082175714 @default.
• W2085269916 cites W2085010530 @default.
• W2085269916 cites W2099364812 @default.
• W2085269916 cites W2116051694 @default.
• W2085269916 cites W2140489062 @default.
• W2085269916 cites W2141287213 @default.
• W2085269916 cites W2154184667 @default.
• W2085269916 cites W2158132325 @default.
• W2085269916 cites W2165470970 @default.
• W2085269916 cites W2340893063 @default.
• W2085269916 doi "https://doi.org/10.1016/j.mvr.2009.08.007" @default.
• W2085269916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19729028" @default.
• W2085269916 hasPublicationYear "2009" @default.
• W2085269916 type Work @default.
• W2085269916 sameAs 2085269916 @default.
• W2085269916 citedByCount "4" @default.
• W2085269916 countsByYear W20852699162012 @default.
• W2085269916 countsByYear W20852699162015 @default.
• W2085269916 countsByYear W20852699162019 @default.
• W2085269916 countsByYear W20852699162022 @default.
• W2085269916 crossrefType "journal-article" @default.
• W2085269916 hasAuthorship W2085269916A5006319533 @default.
• W2085269916 hasAuthorship W2085269916A5030941717 @default.
• W2085269916 hasAuthorship W2085269916A5043141098 @default.
• W2085269916 hasAuthorship W2085269916A5044867102 @default.
• W2085269916 hasAuthorship W2085269916A5051380367 @default.
• W2085269916 hasAuthorship W2085269916A5061954972 @default.
• W2085269916 hasAuthorship W2085269916A5077882891 @default.
• W2085269916 hasConcept C142724271 @default.
• W2085269916 hasConcept C150903083 @default.
• W2085269916 hasConcept C185592680 @default.
• W2085269916 hasConcept C196795494 @default.
• W2085269916 hasConcept C204232928 @default.
• W2085269916 hasConcept C207001950 @default.
• W2085269916 hasConcept C2778143360 @default.
• W2085269916 hasConcept C2778939058 @default.
• W2085269916 hasConcept C2780191036 @default.
• W2085269916 hasConcept C2780278673 @default.
• W2085269916 hasConcept C71240020 @default.
• W2085269916 hasConcept C71924100 @default.
• W2085269916 hasConcept C86803240 @default.
• W2085269916 hasConceptScore W2085269916C142724271 @default.
• W2085269916 hasConceptScore W2085269916C150903083 @default.
• W2085269916 hasConceptScore W2085269916C185592680 @default.
• W2085269916 hasConceptScore W2085269916C196795494 @default.
• W2085269916 hasConceptScore W2085269916C204232928 @default.
• W2085269916 hasConceptScore W2085269916C207001950 @default.
• W2085269916 hasConceptScore W2085269916C2778143360 @default.
• W2085269916 hasConceptScore W2085269916C2778939058 @default.
• W2085269916 hasConceptScore W2085269916C2780191036 @default.
• W2085269916 hasConceptScore W2085269916C2780278673 @default.
• W2085269916 hasConceptScore W2085269916C71240020 @default.
• W2085269916 hasConceptScore W2085269916C71924100 @default.
• W2085269916 hasConceptScore W2085269916C86803240 @default.
• W2085269916 hasIssue "3" @default.
• W2085269916 hasLocation W20852699161 @default.
• W2085269916 hasLocation W20852699162 @default.
• W2085269916 hasOpenAccess W2085269916 @default.
• W2085269916 hasPrimaryLocation W20852699161 @default.
• W2085269916 hasRelatedWork W1983138420 @default.
• W2085269916 hasRelatedWork W2017073093 @default.
• W2085269916 hasRelatedWork W2057651305 @default.
• W2085269916 hasRelatedWork W2093283271 @default.
• W2085269916 hasRelatedWork W2357795286 @default.
• W2085269916 hasRelatedWork W2363305562 @default.
• W2085269916 hasRelatedWork W2415767125 @default.
• W2085269916 hasRelatedWork W4244965244 @default.
• W2085269916 hasRelatedWork W4378348211 @default.
• W2085269916 hasRelatedWork W4387472616 @default.
• W2085269916 hasVolume "78" @default.
• W2085269916 isParatext "false" @default.
• W2085269916 isRetracted "false" @default.

• next