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- W2085274160 abstract "Borrelia burgdorferi (Bb) is the tick-borne etiologic agent of Lyme borreliosis, which has many aspects of autoimmune diseases. Bb is unable to recycle synthesized membrane lipids and lipoproteins. Consequently, a large amount of liposome-like vesicle (Bb-blebs) is shed from the outer bacterial membrane. The influence of Bb-blebs on the cellular immune response is not yet known. As a Bb-blebs model, we established standardized Bb-liposomes, produced from freshly extracted lipids and lipoproteins of live Bb. Bb-liposomes were incorporated via nonendocytotic mechanisms by different human cell types, namely dendritic cells (DC), lymphocytes, and fibroblasts, as visualized by immunofluorescence and transmission electron microscopy. Bb-liposomes were localized in the cytosol and in the nucleus of the cells. With this in mind, we generated in vitro Bb-specific T-cells from nonadherant peripheral blood mononuclear cells by use of Bb-liposomes loaded autologous DC. More than 95% of those T-cells were CD8+ and they killed autologous Bb-liposome-loaded T-cell blasts. These results suggest that Bb-blebs may be responsible for the autoimmune-like appearance of Lyme disease." @default.
- W2085274160 created "2016-06-24" @default.
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- W2085274160 date "2000-05-01" @default.
- W2085274160 modified "2023-09-26" @default.
- W2085274160 title "Lipoproteins from Borrelia burgdorferi Applied in Liposomes and Presented by Dendritic Cells Induce CD8+ T-Lymphocytes in Vitro" @default.
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- W2085274160 doi "https://doi.org/10.1006/cimm.2000.1640" @default.
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