Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085274368> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2085274368 endingPage "328" @default.
- W2085274368 startingPage "321" @default.
- W2085274368 abstract "Increased glucose metabolism through the hexosamine pathway may result in insulin resistance, impaired insulin secretion, and diabetic nephropathy. We hypothesized that variants of GFPT1 encoding glutamine-fructose-6-phosphate amidotransferase, the rate limiting enzyme in this pathway, could increase GFPT1 gene expression and thus susceptibility to diabetes and diabetic nephropathy. To test this hypothesis, we screened for variation in the GFPT1 and flanking regions in Caucasian and African-American individuals. We tested each variant with over 5% allele frequency for an association with type 2 diabetes in Caucasian and African-American populations, and for an association with diabetic nephropathy in African-American subjects. We measured allele specific levels of GFPT1 mRNA and we compared mRNA levels across diagnostic categories for each ethnic group using RNA derived from transformed lymphocytes. None of the 8 variants detected altered the coding sequence or was present in a known regulatory region. We found a marginal association (p = 0.044) of 1/6 variants with diabetes in Caucasian subjects, and marginal associations of 2/7 variants with diabetic nephropathy among African-American subjects (p = 0.025, p = 0.041). Alleles marked by a variant in the 3' untranslated region were equally expressed, but in a small sample, GFPT1 mRNA levels were increased by 60% in Caucasians with diabetic nephropathy compared to diabetic individuals without nephropathy. Variants in the GFPT1 gene show suggestive evidence of an association with diabetic nephropathy among African-American individuals, and increased GFPT1 gene expression may characterize Caucasian subjects with diabetic nephropathy. Both findings need to be confirmed in other populations." @default.
- W2085274368 created "2016-06-24" @default.
- W2085274368 creator A5028663346 @default.
- W2085274368 creator A5030761837 @default.
- W2085274368 creator A5033837626 @default.
- W2085274368 creator A5048284078 @default.
- W2085274368 creator A5060462550 @default.
- W2085274368 creator A5079197783 @default.
- W2085274368 creator A5081996644 @default.
- W2085274368 date "2004-08-01" @default.
- W2085274368 modified "2023-09-30" @default.
- W2085274368 title "Molecular screening of the human glutamine–fructose-6-phosphate amidotransferase 1 (GFPT1) gene and association studies with diabetes and diabetic nephropathy" @default.
- W2085274368 cites W107495204 @default.
- W2085274368 cites W1968005873 @default.
- W2085274368 cites W1971185974 @default.
- W2085274368 cites W1988319209 @default.
- W2085274368 cites W1996767070 @default.
- W2085274368 cites W2007886820 @default.
- W2085274368 cites W2015408724 @default.
- W2085274368 cites W2034201514 @default.
- W2085274368 cites W2037268137 @default.
- W2085274368 cites W2044437167 @default.
- W2085274368 cites W2045753014 @default.
- W2085274368 cites W2070015764 @default.
- W2085274368 cites W2080565765 @default.
- W2085274368 cites W2087910122 @default.
- W2085274368 cites W2095352859 @default.
- W2085274368 cites W2098034076 @default.
- W2085274368 cites W2149007662 @default.
- W2085274368 cites W2155664046 @default.
- W2085274368 cites W4239850481 @default.
- W2085274368 cites W4241515291 @default.
- W2085274368 doi "https://doi.org/10.1016/j.ymgme.2004.05.004" @default.
- W2085274368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15308130" @default.
- W2085274368 hasPublicationYear "2004" @default.
- W2085274368 type Work @default.
- W2085274368 sameAs 2085274368 @default.
- W2085274368 citedByCount "19" @default.
- W2085274368 countsByYear W20852743682014 @default.
- W2085274368 countsByYear W20852743682015 @default.
- W2085274368 countsByYear W20852743682017 @default.
- W2085274368 countsByYear W20852743682020 @default.
- W2085274368 countsByYear W20852743682021 @default.
- W2085274368 countsByYear W20852743682022 @default.
- W2085274368 countsByYear W20852743682023 @default.
- W2085274368 crossrefType "journal-article" @default.
- W2085274368 hasAuthorship W2085274368A5028663346 @default.
- W2085274368 hasAuthorship W2085274368A5030761837 @default.
- W2085274368 hasAuthorship W2085274368A5033837626 @default.
- W2085274368 hasAuthorship W2085274368A5048284078 @default.
- W2085274368 hasAuthorship W2085274368A5060462550 @default.
- W2085274368 hasAuthorship W2085274368A5079197783 @default.
- W2085274368 hasAuthorship W2085274368A5081996644 @default.
- W2085274368 hasConcept C126322002 @default.
- W2085274368 hasConcept C134018914 @default.
- W2085274368 hasConcept C2777180221 @default.
- W2085274368 hasConcept C2779349466 @default.
- W2085274368 hasConcept C2779922275 @default.
- W2085274368 hasConcept C2781184683 @default.
- W2085274368 hasConcept C515207424 @default.
- W2085274368 hasConcept C54355233 @default.
- W2085274368 hasConcept C555293320 @default.
- W2085274368 hasConcept C71924100 @default.
- W2085274368 hasConcept C75972863 @default.
- W2085274368 hasConcept C86803240 @default.
- W2085274368 hasConceptScore W2085274368C126322002 @default.
- W2085274368 hasConceptScore W2085274368C134018914 @default.
- W2085274368 hasConceptScore W2085274368C2777180221 @default.
- W2085274368 hasConceptScore W2085274368C2779349466 @default.
- W2085274368 hasConceptScore W2085274368C2779922275 @default.
- W2085274368 hasConceptScore W2085274368C2781184683 @default.
- W2085274368 hasConceptScore W2085274368C515207424 @default.
- W2085274368 hasConceptScore W2085274368C54355233 @default.
- W2085274368 hasConceptScore W2085274368C555293320 @default.
- W2085274368 hasConceptScore W2085274368C71924100 @default.
- W2085274368 hasConceptScore W2085274368C75972863 @default.
- W2085274368 hasConceptScore W2085274368C86803240 @default.
- W2085274368 hasIssue "4" @default.
- W2085274368 hasLocation W20852743681 @default.
- W2085274368 hasLocation W20852743682 @default.
- W2085274368 hasOpenAccess W2085274368 @default.
- W2085274368 hasPrimaryLocation W20852743681 @default.
- W2085274368 hasRelatedWork W2008264923 @default.
- W2085274368 hasRelatedWork W2032111989 @default.
- W2085274368 hasRelatedWork W2038657938 @default.
- W2085274368 hasRelatedWork W2047956456 @default.
- W2085274368 hasRelatedWork W2061728276 @default.
- W2085274368 hasRelatedWork W2104195310 @default.
- W2085274368 hasRelatedWork W2134392906 @default.
- W2085274368 hasRelatedWork W2153965615 @default.
- W2085274368 hasRelatedWork W2406277046 @default.
- W2085274368 hasRelatedWork W2898804865 @default.
- W2085274368 hasVolume "82" @default.
- W2085274368 isParatext "false" @default.
- W2085274368 isRetracted "false" @default.
- W2085274368 magId "2085274368" @default.
- W2085274368 workType "article" @default.