Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085276492> ?p ?o ?g. }
- W2085276492 endingPage "583" @default.
- W2085276492 startingPage "575" @default.
- W2085276492 abstract "Phencyclidine profoundly alters cerebral metabolism in the rat. This study explored whether cerebral metabolic effects of phencyclidine differed when the drug was self-administered by trained rats, compared with when it was given acutely to naive rats. The regional cerebral uptake of 2-deoxy-d-[1-(D14C] glucose (DG) was examined following two injections of phencyclidine (0.5 mg/kg/injection, i.v.) or saline in freely-moving, drug-experienced rats. Naive controls received phencyclidine or saline according to an identical dose regimen. In self-administering and naive rats, phencyclidine produced many of the same effects on uptake of DG, including the following: decreases in the habenula, inferior colliculus, sensory cortical areas and corresponding thalamic relay nuclei; and increases in limbic areas (entorhinal and retrosplenial cortices, subicular areas). Some regions (auditory and motor cortices, medial geniculate body, globus pallidus) showed different effects in self-administering and naive rats. Another study, in which rats were not self-administering phencyclidine, but had histories of treatment with drugs similar to those of the self-administering rats, indicated that chronic exposure to drug accounted for some of the differences. Furthermore, differences between the effects of phencyclidine in self-administering, versus non-self-administering rats with similar histories suggested that activity in some regions of the brain may relate to training in drug self-administration and/or behavior." @default.
- W2085276492 created "2016-06-24" @default.
- W2085276492 creator A5019337347 @default.
- W2085276492 creator A5024160081 @default.
- W2085276492 creator A5028117769 @default.
- W2085276492 creator A5081353365 @default.
- W2085276492 date "1989-06-01" @default.
- W2085276492 modified "2023-09-26" @default.
- W2085276492 title "Effects of self-administered phencyclidine on regional uptake of 2-deoxy-d-[1-14C]glucose in brain" @default.
- W2085276492 cites W149829678 @default.
- W2085276492 cites W1967805565 @default.
- W2085276492 cites W1969247127 @default.
- W2085276492 cites W1972817694 @default.
- W2085276492 cites W1973667619 @default.
- W2085276492 cites W1975679961 @default.
- W2085276492 cites W1976574822 @default.
- W2085276492 cites W1998405191 @default.
- W2085276492 cites W2002890059 @default.
- W2085276492 cites W2005997674 @default.
- W2085276492 cites W2006567109 @default.
- W2085276492 cites W2008858337 @default.
- W2085276492 cites W2015232052 @default.
- W2085276492 cites W2019378748 @default.
- W2085276492 cites W2024348175 @default.
- W2085276492 cites W2026043391 @default.
- W2085276492 cites W2027684092 @default.
- W2085276492 cites W2030659757 @default.
- W2085276492 cites W2047464854 @default.
- W2085276492 cites W2051100317 @default.
- W2085276492 cites W2055338705 @default.
- W2085276492 cites W2063604509 @default.
- W2085276492 cites W2070182120 @default.
- W2085276492 cites W2084536694 @default.
- W2085276492 cites W2086054216 @default.
- W2085276492 cites W2086486843 @default.
- W2085276492 cites W2090306035 @default.
- W2085276492 cites W2091978914 @default.
- W2085276492 cites W2128754068 @default.
- W2085276492 cites W2138368199 @default.
- W2085276492 cites W2143199663 @default.
- W2085276492 cites W2158767242 @default.
- W2085276492 cites W2163589408 @default.
- W2085276492 cites W2163815564 @default.
- W2085276492 cites W2249543568 @default.
- W2085276492 cites W2253312080 @default.
- W2085276492 cites W2258025409 @default.
- W2085276492 cites W2273934224 @default.
- W2085276492 cites W2399276744 @default.
- W2085276492 cites W2461126290 @default.
- W2085276492 cites W2501463237 @default.
- W2085276492 cites W2081719155 @default.
- W2085276492 doi "https://doi.org/10.1016/0028-3908(89)90136-6" @default.
- W2085276492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2755563" @default.
- W2085276492 hasPublicationYear "1989" @default.
- W2085276492 type Work @default.
- W2085276492 sameAs 2085276492 @default.
- W2085276492 citedByCount "9" @default.
- W2085276492 countsByYear W20852764922012 @default.
- W2085276492 crossrefType "journal-article" @default.
- W2085276492 hasAuthorship W2085276492A5019337347 @default.
- W2085276492 hasAuthorship W2085276492A5024160081 @default.
- W2085276492 hasAuthorship W2085276492A5028117769 @default.
- W2085276492 hasAuthorship W2085276492A5081353365 @default.
- W2085276492 hasConcept C124315065 @default.
- W2085276492 hasConcept C126322002 @default.
- W2085276492 hasConcept C15744967 @default.
- W2085276492 hasConcept C169760540 @default.
- W2085276492 hasConcept C170493617 @default.
- W2085276492 hasConcept C2778187257 @default.
- W2085276492 hasConcept C2778555786 @default.
- W2085276492 hasConcept C2778851735 @default.
- W2085276492 hasConcept C2780278869 @default.
- W2085276492 hasConcept C2781065190 @default.
- W2085276492 hasConcept C42219234 @default.
- W2085276492 hasConcept C529278444 @default.
- W2085276492 hasConcept C67018056 @default.
- W2085276492 hasConcept C71924100 @default.
- W2085276492 hasConcept C98274493 @default.
- W2085276492 hasConceptScore W2085276492C124315065 @default.
- W2085276492 hasConceptScore W2085276492C126322002 @default.
- W2085276492 hasConceptScore W2085276492C15744967 @default.
- W2085276492 hasConceptScore W2085276492C169760540 @default.
- W2085276492 hasConceptScore W2085276492C170493617 @default.
- W2085276492 hasConceptScore W2085276492C2778187257 @default.
- W2085276492 hasConceptScore W2085276492C2778555786 @default.
- W2085276492 hasConceptScore W2085276492C2778851735 @default.
- W2085276492 hasConceptScore W2085276492C2780278869 @default.
- W2085276492 hasConceptScore W2085276492C2781065190 @default.
- W2085276492 hasConceptScore W2085276492C42219234 @default.
- W2085276492 hasConceptScore W2085276492C529278444 @default.
- W2085276492 hasConceptScore W2085276492C67018056 @default.
- W2085276492 hasConceptScore W2085276492C71924100 @default.
- W2085276492 hasConceptScore W2085276492C98274493 @default.
- W2085276492 hasIssue "6" @default.
- W2085276492 hasLocation W20852764921 @default.
- W2085276492 hasLocation W20852764922 @default.
- W2085276492 hasOpenAccess W2085276492 @default.
- W2085276492 hasPrimaryLocation W20852764921 @default.