Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085277613> ?p ?o ?g. }
- W2085277613 endingPage "484" @default.
- W2085277613 startingPage "474" @default.
- W2085277613 abstract "No opioid receptor, mu 1 (OPRM1) gene polymorphisms, including the functional single nucleotide polymorphism (SNP) rs1799971, have been conclusively associated with heroin/other opioid addiction, despite their biological plausibility. We used evidence of polymorphisms altering OPRM1 expression in normal human brain tissue to nominate and then test associations with heroin addiction.We tested 103 OPRM1 SNPs for association with OPRM1 messenger RNA expression in prefrontal cortex from 224 European Americans and African Americans of the BrainCloud cohort. We then tested the 16 putative cis-expression quantitative trait loci (cis-eQTL) SNPs for association with heroin addiction in the Urban Health Study and two replication cohorts, totaling 16,729 European Americans, African Americans, and Australians of European ancestry.Four putative cis-eQTL SNPs were significantly associated with heroin addiction in the Urban Health Study (smallest p = 8.9 × 10(-5)): rs9478495, rs3778150, rs9384169, and rs562859. Rs3778150, located in OPRM1 intron 1, was significantly replicated (p = 6.3 × 10(-5)). Meta-analysis across all case-control cohorts resulted in p = 4.3 × 10(-8): the rs3778150-C allele (frequency = 16%-19%) being associated with increased heroin addiction risk. Importantly, the functional SNP allele rs1799971-A was associated with heroin addiction only in the presence of rs3778150-C (p = 1.48 × 10(-6) for rs1799971-A/rs3778150-C and p = .79 for rs1799971-A/rs3778150-T haplotypes). Lastly, replication was observed for six other intron 1 SNPs that had prior suggestive associations with heroin addiction (smallest p = 2.7 × 10(-8) for rs3823010).Our findings show that common OPRM1 intron 1 SNPs have replicable associations with heroin addiction. The haplotype structure of rs3778150 and nearby SNPs may underlie the inconsistent associations between rs1799971 and heroin addiction." @default.
- W2085277613 created "2016-06-24" @default.
- W2085277613 creator A5002039390 @default.
- W2085277613 creator A5006875478 @default.
- W2085277613 creator A5010195745 @default.
- W2085277613 creator A5012652688 @default.
- W2085277613 creator A5016471979 @default.
- W2085277613 creator A5016817677 @default.
- W2085277613 creator A5019653549 @default.
- W2085277613 creator A5033652669 @default.
- W2085277613 creator A5036089072 @default.
- W2085277613 creator A5036284257 @default.
- W2085277613 creator A5039501195 @default.
- W2085277613 creator A5040592396 @default.
- W2085277613 creator A5043144062 @default.
- W2085277613 creator A5053331577 @default.
- W2085277613 creator A5057848320 @default.
- W2085277613 creator A5064749062 @default.
- W2085277613 creator A5065075154 @default.
- W2085277613 creator A5071355570 @default.
- W2085277613 creator A5077159635 @default.
- W2085277613 creator A5088150924 @default.
- W2085277613 creator A5089075288 @default.
- W2085277613 date "2015-10-01" @default.
- W2085277613 modified "2023-10-14" @default.
- W2085277613 title "Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1" @default.
- W2085277613 cites W1739175964 @default.
- W2085277613 cites W1989309280 @default.
- W2085277613 cites W1993030223 @default.
- W2085277613 cites W1994872818 @default.
- W2085277613 cites W1996783118 @default.
- W2085277613 cites W2006614558 @default.
- W2085277613 cites W2010203932 @default.
- W2085277613 cites W2012743573 @default.
- W2085277613 cites W2013916820 @default.
- W2085277613 cites W2016973436 @default.
- W2085277613 cites W2017316872 @default.
- W2085277613 cites W2019983262 @default.
- W2085277613 cites W2023452013 @default.
- W2085277613 cites W2026884584 @default.
- W2085277613 cites W2030159700 @default.
- W2085277613 cites W2030705868 @default.
- W2085277613 cites W2034717644 @default.
- W2085277613 cites W2042174194 @default.
- W2085277613 cites W2054193591 @default.
- W2085277613 cites W2056233911 @default.
- W2085277613 cites W2058792575 @default.
- W2085277613 cites W2074127159 @default.
- W2085277613 cites W2078530990 @default.
- W2085277613 cites W2078758369 @default.
- W2085277613 cites W2083332683 @default.
- W2085277613 cites W2084650334 @default.
- W2085277613 cites W2085459418 @default.
- W2085277613 cites W2087123651 @default.
- W2085277613 cites W2092170757 @default.
- W2085277613 cites W2097902492 @default.
- W2085277613 cites W2098380904 @default.
- W2085277613 cites W2099814519 @default.
- W2085277613 cites W2100045083 @default.
- W2085277613 cites W2106719141 @default.
- W2085277613 cites W2107755054 @default.
- W2085277613 cites W2112755003 @default.
- W2085277613 cites W2112902993 @default.
- W2085277613 cites W2117970703 @default.
- W2085277613 cites W2121114239 @default.
- W2085277613 cites W2121138811 @default.
- W2085277613 cites W2123411711 @default.
- W2085277613 cites W2124484771 @default.
- W2085277613 cites W2125051725 @default.
- W2085277613 cites W2135895196 @default.
- W2085277613 cites W2143143063 @default.
- W2085277613 cites W2145474755 @default.
- W2085277613 cites W2145971107 @default.
- W2085277613 cites W2146690730 @default.
- W2085277613 cites W2147542352 @default.
- W2085277613 cites W2147919295 @default.
- W2085277613 cites W2149902451 @default.
- W2085277613 cites W2154003551 @default.
- W2085277613 cites W2160440155 @default.
- W2085277613 cites W2161164720 @default.
- W2085277613 cites W2162530578 @default.
- W2085277613 cites W2163013660 @default.
- W2085277613 cites W2163203447 @default.
- W2085277613 cites W2171777347 @default.
- W2085277613 cites W2259938310 @default.
- W2085277613 cites W4213233201 @default.
- W2085277613 doi "https://doi.org/10.1016/j.biopsych.2015.01.003" @default.
- W2085277613 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4519434" @default.
- W2085277613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25744370" @default.
- W2085277613 hasPublicationYear "2015" @default.
- W2085277613 type Work @default.
- W2085277613 sameAs 2085277613 @default.
- W2085277613 citedByCount "58" @default.
- W2085277613 countsByYear W20852776132015 @default.
- W2085277613 countsByYear W20852776132017 @default.
- W2085277613 countsByYear W20852776132018 @default.
- W2085277613 countsByYear W20852776132019 @default.
- W2085277613 countsByYear W20852776132020 @default.