FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2085277785> ?p ?o ?g. }

• W2085277785 endingPage "11" @default.
• W2085277785 startingPage "1" @default.
• W2085277785 abstract "Thyrotropin releasing hormone (TRH) is a neuropeptide with a wide neural distribution and a variety of functions. It modulates neuronal electrophysiological properties, including resting membrane potential, as well as excitatory postsynaptic potential and spike frequencies. We explored, with whole-cell patch clamp, TRH effect on action potential shape in pyramidal neurons of the sensorimotor cortex. TRH reduced spike and after hyperpolarization amplitudes, and increased spike half-width. The effect varied with dose, time and cortical layer. In layer V, 0.5 µM of TRH induced a small increase in spike half-width, while 1 and 5 µM induced a strong but transient change in spike half-width, and amplitude; after hyperpolarization amplitude was modified at 5 µM of TRH. Cortical layers III and VI neurons responded intensely to 0.5 µM TRH; layer II neurons response was small. The effect of 1 µM TRH on action potential shape in layer V neurons was blocked by G-protein inhibition. Inhibition of the activity of the TRH-degrading enzyme pyroglutamyl peptidase II (PPII) reproduced the effect of TRH, with enhanced spike half-width. Many cortical PPII mRNA+ cells were VGLUT1 mRNA+, and some GAD mRNA+. These data show that TRH regulates action potential shape in pyramidal cortical neurons, and are consistent with the hypothesis that PPII controls its action in this region." @default.
• W2085277785 created "2016-06-24" @default.
• W2085277785 creator A5018617976 @default.
• W2085277785 creator A5023977286 @default.
• W2085277785 creator A5029509785 @default.
• W2085277785 creator A5031126052 @default.
• W2085277785 creator A5037661087 @default.
• W2085277785 creator A5065668445 @default.
• W2085277785 date "2014-07-01" @default.
• W2085277785 modified "2023-10-18" @default.
• W2085277785 title "TRH regulates action potential shape in cerebral cortex pyramidal neurons" @default.
• W2085277785 cites W1481205391 @default.
• W2085277785 cites W1486689401 @default.
• W2085277785 cites W1547399881 @default.
• W2085277785 cites W1968329147 @default.
• W2085277785 cites W1970384874 @default.
• W2085277785 cites W1970719523 @default.
• W2085277785 cites W1972032787 @default.
• W2085277785 cites W1976728824 @default.
• W2085277785 cites W1979022412 @default.
• W2085277785 cites W1985708693 @default.
• W2085277785 cites W1986000136 @default.
• W2085277785 cites W1989816805 @default.
• W2085277785 cites W1990378654 @default.
• W2085277785 cites W2002411184 @default.
• W2085277785 cites W2004309850 @default.
• W2085277785 cites W2013748304 @default.
• W2085277785 cites W2014741978 @default.
• W2085277785 cites W2016252890 @default.
• W2085277785 cites W2023148260 @default.
• W2085277785 cites W2035078135 @default.
• W2085277785 cites W2037068180 @default.
• W2085277785 cites W2040860320 @default.
• W2085277785 cites W2049975284 @default.
• W2085277785 cites W2052994030 @default.
• W2085277785 cites W2053782065 @default.
• W2085277785 cites W2058610097 @default.
• W2085277785 cites W2060023327 @default.
• W2085277785 cites W2060923069 @default.
• W2085277785 cites W2063594532 @default.
• W2085277785 cites W2068757410 @default.
• W2085277785 cites W2083478366 @default.
• W2085277785 cites W2110402020 @default.
• W2085277785 cites W2114793335 @default.
• W2085277785 cites W2120067804 @default.
• W2085277785 cites W2122566753 @default.
• W2085277785 cites W2132844065 @default.
• W2085277785 cites W2134823086 @default.
• W2085277785 cites W2139366417 @default.
• W2085277785 cites W2147107991 @default.
• W2085277785 cites W2154899601 @default.
• W2085277785 cites W2164313305 @default.
• W2085277785 cites W2168254795 @default.
• W2085277785 cites W2171513174 @default.
• W2085277785 cites W2496006906 @default.
• W2085277785 cites W1975673967 @default.
• W2085277785 doi "https://doi.org/10.1016/j.brainres.2014.05.015" @default.
• W2085277785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24842001" @default.
• W2085277785 hasPublicationYear "2014" @default.
• W2085277785 type Work @default.
• W2085277785 sameAs 2085277785 @default.
• W2085277785 citedByCount "7" @default.
• W2085277785 countsByYear W20852777852015 @default.
• W2085277785 countsByYear W20852777852016 @default.
• W2085277785 countsByYear W20852777852020 @default.
• W2085277785 countsByYear W20852777852023 @default.
• W2085277785 crossrefType "journal-article" @default.
• W2085277785 hasAuthorship W2085277785A5018617976 @default.
• W2085277785 hasAuthorship W2085277785A5023977286 @default.
• W2085277785 hasAuthorship W2085277785A5029509785 @default.
• W2085277785 hasAuthorship W2085277785A5031126052 @default.
• W2085277785 hasAuthorship W2085277785A5037661087 @default.
• W2085277785 hasAuthorship W2085277785A5065668445 @default.
• W2085277785 hasConcept C112592302 @default.
• W2085277785 hasConcept C12554922 @default.
• W2085277785 hasConcept C126322002 @default.
• W2085277785 hasConcept C131453863 @default.
• W2085277785 hasConcept C134018914 @default.
• W2085277785 hasConcept C148762608 @default.
• W2085277785 hasConcept C169760540 @default.
• W2085277785 hasConcept C17077164 @default.
• W2085277785 hasConcept C181911157 @default.
• W2085277785 hasConcept C185263204 @default.
• W2085277785 hasConcept C185592680 @default.
• W2085277785 hasConcept C2776216936 @default.
• W2085277785 hasConcept C2778437258 @default.
• W2085277785 hasConcept C2781041448 @default.
• W2085277785 hasConcept C66974803 @default.
• W2085277785 hasConcept C71240020 @default.
• W2085277785 hasConcept C71315377 @default.
• W2085277785 hasConcept C71924100 @default.
• W2085277785 hasConcept C86803240 @default.
• W2085277785 hasConceptScore W2085277785C112592302 @default.
• W2085277785 hasConceptScore W2085277785C12554922 @default.
• W2085277785 hasConceptScore W2085277785C126322002 @default.
• W2085277785 hasConceptScore W2085277785C131453863 @default.
• W2085277785 hasConceptScore W2085277785C134018914 @default.
• W2085277785 hasConceptScore W2085277785C148762608 @default.

• next