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• W2085280361 abstract "Human cytomegalovirus (HCMV) forms two different membrane protein complexes, gH/gL/gO and gH/gL/UL128/UL130/UL131, that function in different cell types. gH/gL/gO appears to be important for HCMV entry into or spread between fibroblasts, processes that occur at neutral pH. We demonstrated that HCMV entry into epithelial and endothelial cells requires gH/gL/UL128–131 and involves endocytosis and low pH. A complex of all five HCMV proteins, gH, gL, UL128, UL130, and UL131, is the functionally important mediator of this entry pathway into epithelial/endothelial cells. Here, we report that expression of gH/gL/UL128–131 in ARPE-19 epithelial cells causes the cells to be resistant to HCMV infection. Another HCMV glycoprotein, gB, did not interfere, and expression of all five gH/gL/UL128–131 proteins was required for this interference. gH/gL/UL128–131 interference was at the stage of virus entry into cells rather than the initial adsorption onto cell surfaces or after-entry defects. By contrast, expression of gH/gL/UL128–131 in primary human fibroblasts did not block HCMV infection. Previously, interference by retrovirus and herpes-simplex-virus entry mediators resulted from sequestration or obstruction of receptors. We concluded that epithelial cells express gH/gL/UL128–131 receptors that mediate HCMV entry. Fibroblasts either lack the gH/gL/UL128–131 receptors, the receptors are more numerous, or fibroblasts express other functional receptors." @default.
• W2085280361 created "2016-06-24" @default.
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• W2085280361 date "2008-09-16" @default.
• W2085280361 modified "2023-10-18" @default.
• W2085280361 title "HCMV gH/gL/UL128–131 interferes with virus entry into epithelial cells: Evidence for cell type-specific receptors" @default.
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• W2085280361 doi "https://doi.org/10.1073/pnas.0804365105" @default.
• W2085280361 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2544588" @default.
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