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• W2085280607 abstract "We previously demonstrated that monocytes produce IL‐23 during Francisella infection, and that IL‐23 induces IFNγ from NK cells. Here, we demonstrate that IFNγ‐priming of monocytes enhances IL‐23 production during Francisella infection. This effect was seen on the IL12/23 p40 subunit. Induction of IL‐12/23 p40 is reported to be enhanced by IRF‐1 and IRF‐8. Consistently, microarray analysis of IFNγ‐treated monocytes revealed a significant induction of the IRFs. Interestingly, IFNγ‐primed monocytes produced IL‐12 p70, a more potent inducer of IFNγ than IL‐23. We propose that there exists an amplification loop between monocyte IL‐23 and NK/T cell IFNγ that leads to IL‐12 p70 production." @default.
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• W2085280607 date "2008-03-03" @default.
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• W2085280607 title "IFNγ enhances IL-23 production during<i>Francisella</i>infection of human monocytes" @default.
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• W2085280607 doi "https://doi.org/10.1016/j.febslet.2008.02.058" @default.
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